Pharmacokinetic Investigation of Increased Efficacy Against Malignant Gliomas of Carboplatin Combined With Hyperbaric Oxygenation

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概要

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• The efficacy of intravenous administration of 400 mg carboplatin/m2 body surface area over 60 minutes combined with hyperbaric oxygenation (HBO) therapy (0.2 MPa for 60 min) was investigated in 6 Japanese patients (aged 36-67 years) with malignant or brainstem gliomas. Plasma ultra-filtrate samples were analyzed by high-performance liquid chromatography to evaluate the relationship between efficacy and pharmacokinetics. Brain tumor response was evaluated by magnetic resonance imaging as a function of maximum plasma concentration, area under the curve, or mean residence time (MRT) for carboplatin. The MRT for carboplatin in the complete or partial response group (mean ± standard deviation 4.3 ± 1.7 hrs; 6 courses in 3 patients) was significantly longer (p < 0.05) than that in the progressive disease group (2.4 ± 0.1 hrs; 3 courses in 3 patients), but maximum plasma concentration and area under the curve showed no differences. These results suggest that HBO therapy prolongs the biological residence time of carboplatin. MRT for carboplatin may be useful for predicting continuation or modification of chemotherapy and/or clinical antitumor effects in patients with malignant gliomas.

• 2009-05-15

著者

• Yamazaki Hiroshi

  Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University

• SHIMIZU Makiko

  Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University

• HASHIMOTO Takuo

  Department of Neurosurgery, St. Marianna University School of Medicine

• YOSHIDA Yasuyuki

  Department of Pathology, Osaka Koseinenkin Hospital

• Shimizu Makiko

  Showa Pharmaceutical University

• Shimizu M

  Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University

• Shimizu Makiko

  Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.

• Shimizu Makiko

  Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University

• Shimizu Makiko

  Laboratory For Genetics Of Allergic Diseases Snp Research Center Riken

• SUZUKI Yu

  Department of Neurosurgery, St. Marianna University School of Medicine, Kawasaki

• TANAKA Katsuyuki

  Department of Neurosurgery, St. Marianna University School of Medicine, Kawasaki

• NEGISHI Daisuke

  Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University

• Hashimoto Takuo

  Department Of Neurosurgery St. Marianna University School Of Medicine Kawasaki

• Hashimoto Takuo

  Department Of Neurological Surgery Tokyo Women's Medical College

• Tanaka Katsuyuki

  Department Of Mechanical System Engineering School Of Engineering University Of Shiga Prefecture

• Suzuki Yu

  Department Of Biotechnology Tokyo University Of Agriculture And Technology

• Suzuki Yu

  Department Of Neurosurgery St. Marianna University School Of Medicine Kawasaki

• Saito Miwako

  Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.

• Negishi Daisuke

  Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University

• Yamazaki Hiroshi

  Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University

• Yoshida Yasuyuki

  Department Of Neurosurgery St. Marianna University School Of Medicine Kawasaki

• Tanaka Katsuyuki

  Department Of Neurosurgery St. Marianna University School Of Medicine Kawasaki

• Tanaka Katsuyuki

  Department Of Biological Science Graduate School Of Science Hiroshima University

• Tanaka Katsuyuki

  Department Of Applied Physics Faculty Of Science Tokyo Institute Of Technology

• Yoshida Yasuyuki

  Department Of Materials Science And Ceramic Technology Shonan Institute Of Technology

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