4'-Hydroxylation of Flurbiprofen by Rat Liver Microsomes in Fasting and Feeding Conditions(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
We examined the 4'-hydroxylation of flurbiprofen in rat hepatocytes and liver microsomes in order to know whether the metabolism of flurbiprofen is changed on its administration to experimental animals after overnight fasting, because starvation and fasting change both the composition of cytochrome P450s (CYPs) and metabolic activity. CYPs involved in the hydroxylation were determined by various CYP inhibitors and inhibitory antibodies against rat CYP2C11 and CYP2E1 using the microsomes in fasting and feeding. The results provided a possibiliy that the 4'-hydroxylation might be regulated by CYP2C11, but not by CYP2E1, at fasting rather than feeding.
- 公益社団法人日本薬学会の論文
- 2003-10-01
著者
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松本 宜明
日本大学薬学部臨床薬物動態学ユニット
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SHIMIZU Makiko
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
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MATSUMOTO Yoshiaki
Department of Clinical Pharmacology and Toxicology, Showa College of Pharmaceutical Sciences
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FUKUOKA Masamichi
Department of Clinical Pharmacology and Toxicology, Showa College of Pharmaceutical Sciences
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Matsumoto Y
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Fujii M
Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences
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Fujii Makiko
Department Of Pharmaceutics Showa College Of Pharmaceutical Science
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SHIMIZU Makiko
Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University
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MATSUSHITA Reiko
Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University
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Shimizu Makiko
Showa Pharmaceutical University
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Shimizu M
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Shimizu Makiko
Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.
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Shimizu Makiko
Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University
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Shimizu Makiko
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Fujii M
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Matsumoto Yoshiaki
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Fukuoka Masamichi
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Fukuoka Masamichi
Division Of Medical Chemistry National Institute Of Hygienic Sciences
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Matsumoto Yoshiaki
Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences
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松本 宣明
Division Of Applied Life Science Graduate School Of Engineering Sojo University
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Fukuoka M
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Saito Miwako
Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.
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Matsumoto Yoshiaki
Department Of Clinical Pharmacokinetics College Of Pharmacy Nihon University
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