腎移植におけるシクロスポリンのAUC<0-4>推定法の評価

概要

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Cyclosporine (CyA) is the most commonly used immunosuppressive agent in patients who undergo kidney transplantation. Dosage adjustment of CyA is usually based on trough levels. Recently, trough levels have been replacing the area under the concentration-time curve during the first 4 h after CyA administration (AUC_<0-4>). The aim of this study was to compare the predictive values obtained using three different methods of AUC_<0-4> monitoring. AUC_<0-4> was calculated from O to 4 h in early and stable renal transplant patients using the trapezoidal rule. The predicted AUC_<0-4> was calculated using three different methods: the multiple regression equation reported by Uchida et al.; Bayesian estimation for modified population pharmacokinetic parameters reported by Yoshida et al.; and modified population pharmacokinetic parameters reported by Cremers et al.
社団法人日本薬学会の論文
2005-05-01