中空型坐剤基剤を用いた直腸投与製剤の基礎と臨床 : 10年の歩みと今後の展望

概要

論文の詳細を見る
In the last decade, several attempts concerning a novel rectal dosage form, hollow-type suppository containing various drugs, have been successfully made in the field of rectal drug delivery system. The hollow-type suppository, a new type with a hollow cavity, into which drugs, in the form of liquid containing aqueous solution, semisolid, solid such as powder, and so on, can be placed,is employed in clinical applications as well as for pharmaceutical studies. It has been proved that the hollow-type suppository has some advantages of pharmaceutical characteristics such as rapid and complete drug release from the preparation, in comparison with the conventional suppository. On the other hand, the hollow-type suppository is considerable benefit to medication and nursing in patients, for instance, the pain relief in the terminal cancer patients by the administration of morphine. In this review, we summarize overall advantages and utilities of pharmaceutical characteristics of this suppository elucidated from the formulation studies, and discuss clinical significances and subjects in subsequent research.
日本医療薬学会の論文
1994-03-20