中空坐剤の製剤学的評価(第1報)油性中空坐剤からのBrilliant Blue FCFの放出特性

概要

論文の詳細を見る
A new type of suppository with a hollow cavity into which drugs, in the form of powder, liquid, or solid could be placed was constructed. The advantage of the use of this hollow-type suppository is that interactions between drug and the oily-base suppository materials can be essentially eliminated. Brilliant blue FCF (BB) was selected as a model drug since the rate of dissolution could be observed visually. New type suppositories and conventional type suppositories were constructed with four different oily-base materials. The dissolution rates of BB in vitro from new-type could then be compared with those of conventional-type suppositories made from the same base material. It was found that with conventional construction, the rates differed considerably depending on the base material. With the new type no difference was found between the four materials tested. Similar results were obtained if the BB was added to the suppository as a fine powder, aqueous solution or macrogol mixture. Plasma concentration of BB were measured in rabbits after the rectal administration of the suppositories. These data on bioavailability showed that the hollow-type suppositories were less influenced by kinds of the base material than were the conventional types.
1984-05-25