塩酸モルヒネ末または水溶液充填中空坐剤の調製と評価

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The bioavailability of morphine following rectal administration of a hollow-type suppository containing morphine hydrochloride (10mg) in different-added forms was evaluated in patients under general anesthesia during operation. The hollow-type suppositories were prepared using Witepsol H-15, a suppository containing 1% morphine solution (morphine solution, 10mg/ml) or 10% morphine powder diluted with lactose (morphine powder, 100mg) in its cavity. The plasma concentration of morphine and its metabolite, morphine-3-glucuronide (M-3-G), were determined. The mean Cmax and AUC of morphine following rectal administration of the hollow-type suppository containing morphine solution were higher than those obtained from the suppository containing morphine powder, whereas the mean Cmax and AUC of M-3-G were lower than those following administration of the suppository containing morphine powder. The mean AUC ratio of M-3-G to morphine following administration of the morphine-powder containing suppository was three times larger than that of the suppository containing morphine solution. The hollow-type suppository containing morphine solution or powder could thus be useful for the pain control of patients with cancer. These findings suggest that the hollow-type suppository containing morphine powder or solution, which could be adjusted to specific individual dosages, constitutes a useful clinical application for the cancer patient from the viewpoint of enhancing the quality of life.
日本医療薬学会の論文
1993-08-20

塩酸モルヒネ末または水溶液充填中空坐剤の調製と評価

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