モノクロナール抗体を用いた螢光偏光免疫測定法による生体部分肝移植患者の全血中シクロスポリン濃度の測定とその評価

概要

論文の詳細を見る
Clinical utility of fluorescence polarization immunoassay with a monoclonal antibody (m-FPIA) was investigated in the determination of whole blood ciclosporin (CYA) levels in partial liver transplant recipient. CYA levels determined by m-FPIA were almost identical with the values determined by radioimmunoassay with monoclonal antibody (m-RIA), while they were 35% higher than the levels analyzed by HPLC. The values determined by fluorescence polarization immunoassay with a polyclonal antibody (p-FPIA) were not correlated with CYA levels determined by m-FPIA. It was concluded that m-FPIA was accurate and precise method for determination of CYA levels, so that it was reliable and useful one, The most characteristic advantage of this method is that we can obtain the results within only 30 minutes after the blood was taken from patients.
日本医療薬学会の論文
1992-03-20