各種消毒薬の殺真菌効果

概要

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Fungicidal activities of six kinds of disinfectants, such as chlorhexidine digluconate (CHX), benzalkonium chloride (BAC), alkylpolyaminoethylglycine (APE), formalin (FON), cresol soap (CRS) and povidone iodine (PVI) were investigated against 8 clinical isolated fungi, which included 1 Aspergillus niger, 1 Aapergillus terreus, 2 Candida albicans, 2 Candida tropicalis, 1 Candida Parapsilosis, 1 Cryptococcus neoformans, 1 Trichophyton rubeum and 1 Rhodotorula glutinis strains, Concentrations of fungal suspensions were adjusted to approximately 10^7CFU/ml for A.niger, A.terreus and T.rubrum and 10^<8-9>CFU/ml for C.albicans (A), (B), C.tropicalis (A), (B), C.parapsilosis, C.neoformans and R.glutinis strains, respectively. The fungal suspensions with the various concentration of disinfectant were incubated at 25℃, for 15, 30, 60min. and 24 hrs, respectively. An aliquot (0.1ml) was inoculated onto the Sabouraud-glucose agar plates, and the growth was observed after 7 days of incubation at 25℃, Among the 5 strains tested, A.niger was the most resistant one to all disinfectants examined, and 0.4% concentration of CHX, APE or CRS was found to be effective against A.niger strain for 1hr. It was considered that BAC, FON or PVI was more effective against the fungi tested than CHX, APE or CRS in short time.
1992-08-20