Correlation between ζ-Potential of a Cell in a New Cationic Disinfectant Solution and Minimum Inhibitory Concentration of the Disinfectant

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In the previous paper, we described the synthesis of new quaternary ammonium salts with antimicrobial activity : N-alkyl-N-2-hydroxyethyl-N, N-dimethylammonium butyl phosphate (4) and N-alkyl-N-(2-hydroxy-3-phenoxyl)-propyl-N, N-dimethylammonium butyl phosphate (5). In this study, we examined the relationship between the MIC (minimum inhibitory concentration) of these new cationic disinfectants, 4 (six compounds) and 5 (three compounds), and the ζ-potential against Escherichia coli in solutions of these compounds. The MIC values of these disinfectants against E. coli were highly correlated with the concentration that induced electric charge inversion (ζ-potential=0) of E. coli from negative to positive.
公益社団法人日本薬学会の論文
1994-12-15