タール剤の成分研究(第9報)アミノ酸の乾留による生理活性物質の生成その3チロシン乾留成績体中の抗糸状菌性物質について

概要

論文の詳細を見る
Isolation and structure determination of antifungal principles from tyrosine pyrolysate are described. L-Tyrosine was heated at 350-400°and seven antifungal constituents (I-VII) were isolated from the pyrolysate by a suitable combination of distilation, column chromatography, and gel filtration. Active principles ; (I), mp 230° (subl.), C_<14>H_<14>O_2 ; (II), mp 265° (dec.), C_<14>H_<12>O_2 ; (III), mp 130-131°, C_<14>H_<14>O_2 ; (IV), mp 114-115° ; C_<14>H_<15>NO ; (V), mp 193-195°, C_<11>H_9NO ; (VI), mp 244-245°, C_<16>H_<13>NO ; (VII), mp 144-145°, C_<13>H_<13>NO. These were found to be identical with 4,4'-dihydroxy-dibenzyl, 4,4'-dihydroxy-trans-stilbene, 4-hydroxybenzyl p-tolyl ether, N-phenyltyramine, 3-(p-hydroxyphenyl) pyridine, 3-(p-hydroxyphenyl)-6-methylquinoline, and 4-amino-2'-hydroxydiphenylmethane, respec-tively.
社団法人日本薬学会の論文
1978-07-25