Isolation and Structure Studies of Mutagenic Principles in Amino Acid Pyrolysates

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概要

• 論文の詳細を見る

• The present paper describes the detail of the serach of mutagenic principles in tars from amino acids, especially from tryptophan. A series of amino acids was pyrolyzed and was tested their mutagenicity to find that basic fractions from pyrolysates of tryptophan, ornitine, glutamic acid, serine, lysine and creatine showed potent mutagenicities to TA98 than the fractions from pyrolysates of other amino acids. Among them the active principles in the pyrolysate of tryptophan were identified as 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b] indole (designated as Trp-P-1) and 3-amino-1-methyl-5H-pyrido [4,3-b] indole (designated as Trp-P-2). Among several antimicrobial tar constituents, it was found that 2-amino-5-phenylpyridine, benzo [f] quinoline and phenanthridine also were mutagenic.

• 社団法人日本薬学会の論文
• 1978-02-25

著者

• 岡本 敏彦

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 辻 邦郎

  静岡薬科大学

• 辻 邦郎

  静岡県大 薬

• 板井 昭子

  東大・薬

• 辻 邦郎

  静岡県大・薬

• 若林 敬二

  Shizuoka College of Pharmacy

• 板井 昭子

  Faculty of Pharmaceutical Science, University of Tokyo

• 清野 祐子

  National Cancer Center Institute

• 長尾 美奈子

  国立がんセ・研・生化 横浜国大・工

• 首藤 紘一

  東京大・薬学

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