NEW DIMERIC ANALOGS OF 2-AMINODIPYRIDO [1,2-a : 3', 2'-d] IMIDAZOLE : SYNTHESIS AND INTERACTION WITH DNA

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概要

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• New dimeric analogs of intercalative 2-aminodipyrido-[1,2-a : 3', 2'-d] imidazole (Glu-P-2), a potent muta-carcinogen isolated from a pyrolysate of L-glutamic acid, were synthesized. The high affinity of these compounds to DNA was demonstrated by fluorescence spectroscopic studies and by their effects in raising the melting temperature (T_M) of DNA.

• 1982-08-25

著者

• 岡本 敏彦

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 首藤 紘一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 首藤 紘一

  Facutly Of Pharmaceutical Sciences University Of Tokyo

• 岡本 敏彦

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 李 金星

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 橋本 祐一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 首藤 紘一

  東京大・薬学

• 太田 敏晴

  Faculty Of Pharmaceutical Sciences University Of Tokyo

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