Deoxyribonucleic Acid Modification by Mutagenic 3-Amino-1-methyl-5H-pyrido [4,3-b] indole : The Chemical Events
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概要
- 論文の詳細を見る
3-Amino-1-methyl-5H-pyrido [4,3-b] indole (Trp-P-2) is a mutagen/carcinogen isolated from a pyrolysate of L-tryptophan. The active metabolite of Trp-P-2,3-hydroxyamino-1-methyl-5H-pyrido [4,3-b] indole (N-OH-Trp-P-2), was synthesized and the chemical reactions of N-OH-Trp-P-2 with deoxyribonucleic acid were investigated. The structure of the nucleic acid base covalently bound with Trp-P-2 was elucidated as 3-(C^8-guanyl) amino-1-methyl-5H-pyrido [4,3-b] indole (Gua-Trp-P-2) by comparison with a synthetic sample. The initial chemical events in carcinogenesis caused by Trp-P-2 were established.
- 公益社団法人日本薬学会の論文
- 1984-11-25
著者
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岡本 敏彦
Faculty of Pharmaceutical Sciences, University of Tokyo
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首藤 紘一
Facutly Of Pharmaceutical Sciences University Of Tokyo
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岡本 敏彦
Faculty Of Pharmaceutical Sciences University Of Tokyo
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橋本 祐一
Faculty of Pharmaceutical Sciences, University of Tokyo
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首藤 紘一
東京大・薬学
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