27 マイトマイシンCと仔牛胸腺DNAとの反応修飾ヌクレオチドの分離と構造

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概要

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• Mitomycin C (MMC), the potent antibiotic and clinically useful antitumor agent was catalytically reduced in the presence of calf thymus DNA. The modified DNA (1mol MMC/200-300mol P) was hydrolysed with Nuclease P1 to give three modified nucleotides; MG-1, MG-2, and MA. The modified nucleotides were separated with semi-preparative high performance liquid chromatography. Ultra-violet spectra and nmr spectra of MG-1, MG-2, and MA were obtained. The possible structures of MG-1, MG-2, and MA were deduced from these spectral data, stability in acidic or basic conditions, enzymatic hydrolysis, and investigation of acid hydrolysates.

• 1981-09-10

著者

• 岡本 敏彦

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 首藤 紘一

  Facutly Of Pharmaceutical Sciences University Of Tokyo

• 首藤 紘一

  東大・薬

• 岡本 敏彦

  東大・薬

• 岡本 敏彦

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 首藤 紘一

  東京大・薬学

• 橋本 祐一

  東大・薬

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