Chemical Conversion of Kobusine. Cleavage and Regeneration of the Bridged C_<14>-C_<20> Bond

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概要

• 論文の詳細を見る

• An aconite alkaloid, kobusine (1) was converted to a C_<14>-C_<20> bond cleaved derivative (12) by a novel fragmentation reaction via a chloramine (11). Possible mechanisms were discussed in which participation of anionic nitrogen was proposed. The C_<14>-C_<20> bond regeneration in compound (12) was also accomplished by an intramolecular Grignard type reaction.

• 公益社団法人日本薬学会の論文
• 1978-10-25

著者

• 岡本 敏彦

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 岡本 敏彦

  東大・薬

• 岡本 敏彦

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 岡本 敏彦

  千葉大学薬学部

• 八並 高志

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 古矢 修一

  Chemistry Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.,

• 古矢 修一

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 古矢 修一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 八並 高志

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

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