Reaction of Aromatic Heterocyclic Nitro Compounds with Potassium Cyanide. II

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概要

• 論文の詳細を見る

• On the reaction of 5-, 6-, 7-, and 8-nitroquinoline with potassium cyanide in methanol solution, always two kinds of compound were obtained in a moderate yield. The one was o-methoxyquinoline-carbonitrile, in which the cyano group is introduced in ortho-position to the nitro group and then the nitro group is replaced by a methoxyl group, and the other was 1-aminosoxazoloquinoline, in which the nitro group was reduced to hydroxyamino group and this hydroxyamino group was cyclized to an isoxazole ring with the cyano group introduced at ortho-position of the original nitro group. However, in the reaction of 4-nitroquinoline, 4-methoxyquinoline was obtained as a sole product.

• 公益社団法人日本薬学会の論文
• 1969-01-25

著者

• 岡本 敏彦

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 高山 浩明

  Faculty Of Pharmaceutical Sciences Teikyo University

• 岡本 敏彦

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 岡本 敏彦

  Sato Pharmaceutical Co. Ltd.

• 高橋 浩

  Hoshi Institute of Pharmaceutical Sciences

• 池田 勝

  Product Development Laboratories Sankyo Co. Ltd.

• 高橋 浩

  (Present address)Hoshi College of Pharmacy.

• 池田 勝

  Faculty of Pharmaceutical Sciences, University of Tokyo

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