An Improved Synthesis of 24,24-Difluoro-1α, 25-dihydroxyvitamin D_3 from Readily Available Vitamin D_2
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概要
- 論文の詳細を見る
An improved synthesis of a highly potent vitamin D_3 analog, 24,24-difluoro-1α, 25-dihydroxyvitamin D_3 (1b)has been accomplished via vitamin D_2-SO_2 adducts. The introduction of fluorine atoms was performed by treating the α-keto ester (11) with diethylaminosulfur trifluoride. The total yield was 12.5% from inexpensive vitamin D_2 in 11 steps. This sequence is sufficiently straightforward to be conducted on a gram scale.
- 社団法人日本薬学会の論文
- 1995-02-15
著者
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高山 浩明
Faculty Of Pharmaceutical Sciences Teikyo University
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高山 浩明
帝京大学 薬 薬化
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高山 浩明
帝京大薬学部
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高山 浩明
帝京大学薬学部
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近藤 文博
Faculty Of Pharmaceutical Sciences Teikyo University
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安藤 香織
Faculty of Pharmaceutical Sciences, Teikyo University
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小池 文明
Faculty of Pharmaceutical Sciences, Teikyo University
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安藤 香織
Faculty Of Pharmaceutical Sciences Teikyo University:(present Address)college Of Education Universit
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小池 文明
Faculty Of Pharmaceutical Sciences Teikyo University
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