Acid-Catalyzed Double-Cyclization Reactions of N, N-Dibenzylamino-acetaldehyde Dialkyl Acetals and Related Compounds : General Sunthesis of 7,12-Dihydro-5H-6,12-methanodibenz-[c, f]azocines and Related Compounds
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概要
- 論文の詳細を見る
A number of N, N-dibenzylaminoacetaldehyde diakyl acetales (1) double-cyclized in 70% perchloric acid or triflic acid (trifluoromethanesulfonic acid) to give good yields of 7,12-dihydro-5H-6,12-methanodibenz[c, f]azocines (2) even when a powerful electron-withdrawing substituent, for example a nitro group, was present on the benzene ring. Triflic acid treatment of α-dibenzylaminoketones (3) caused double-cyclization to give 12-substituted derivatives of 2.
- 公益社団法人日本薬学会の論文
- 1986-05-25
著者
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高山 浩明
Faculty Of Pharmaceutical Sciences Teikyo University
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岡本 敏彦
Faculty Of Pharmaceutical Sciences University Of Tokyo
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岡本 敏彦
Sato Pharmaceutical Co. Ltd.
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鈴木 高義
Faculty of Pharmaceutical Sciences, Teikyo University
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高本 正幸
Faculty of Pharmaceutical Sciences, Tokyo University
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鈴木 高義
Faculty Of Pharmaceutical Sciences Teikyo University
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高本 正幸
Faculty Of Pharmaceutical Sciences Tokyo University
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