Identification of an Ultimate Mutagen of 10-Azabenzo [α] pyrene : Microsomal Oxidation of 10-Azabenzo [α] pyrene to 10-Azabenzo [α] pyrene-4,5-oxide
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概要
- 論文の詳細を見る
10-Azabenzo [α] pyrene (10-ABP), one of most active mutagens, was incubated with microsomal protein. 10-ABP-4,5-oxide was found by high performance liquid chromatography in the presence of epoxide hydratase inhibitor, 3,3,3-trichloropropyrene-1,2-oxide (TCPO). In the absence of TCPO, formation of 10-ABP-4,5-oxide was almost negligible and trans-4,5-dihydroxy-4,5-dihydro-10-ABP was found as a major metabolite.
- 公益社団法人日本薬学会の論文
- 1979-10-25
著者
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岡本 敏彦
Faculty of Pharmaceutical Sciences, University of Tokyo
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首藤 紘一
Faculty of Pharmaceutical Sciences, University of Tokyo
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北原 嘉泰
Faculty of Pharmaceutical Sciences, University of Tokyo
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北原 嘉泰
Faculty Of Pharmaceutical Sciences University Of Tokyo
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奥田 晴宏
Faculty Of Pharmaceutical Sciences University Of Tokyo
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岡本 敏彦
Faculty Of Pharmaceutical Sciences University Of Tokyo
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首藤 紘一
東京大・薬学
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