Reaction of 1-Naphthylhydroxylamine with Calf Thymus Deoxyribonucleic Acid. Isolation and Synthesis of N-(Guanin-C^8-yl)-1-naphthylamine

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概要

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• A possible activated form of 1-naphthylamine, N-hydroxy-1-naphthylamine, reacted with the C^8-position of guanine in deoxyribonucleic acid (DNA). Hydrolysis of the modified DNA with nuclease and acid gave N-(guanin-C^8-yl)-1-naphthylamine as a modified base. The C^8-position of guanine seems to be a common site of attack on DNA by activated muta-carcinogenic aromatic amines.

• 1981-09-25

著者

• 岡本 敏彦

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 首藤 紘一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 首藤 紘一

  Facutly Of Pharmaceutical Sciences University Of Tokyo

• 岡本 敏彦

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 室伏 良信

  Chemical Research Laboratories:sankyo Company Ltd.

• 橋本 祐一

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 首藤 紘一

  東京大・薬学

• 室伏 良信

  Faculty of Pharmaceutical Sciences, University of Tokyo

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