アプリンジン体内動態解析における線形モデルと非線形モデルの比較

概要

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The pharmacokinetic parameters were estimated and the pharmacokinetic models of aprindine were evaluated in patients. Two pharmacokinetic models were used, comprising a linear elimination model and a non-linear elimination model, both one-compartment models in which first-order absorption is assumed. Twenty-two serum levels of patients in terms of TDM were measured and the pharmacokinetic parameters were estimated using the simple pool method. The pharrnacokinetic parameters estimated using a linear model were ka= 0.244 (hr^<-1>), ke=0.020 (hr^<-1>) and Vd=1.778 (1/kg), while those using a non-linear model were ka=0.666 (hr^<-1>). Km=2.022 (μg/ml), Vmax=0.l06 (mg/hr/kg) and Vd=2.754 (1/kg). The non-linear model was more suitable than the linear model for the AIC (linear model : -12.59,non-linear model : -19.61). The parameters estimated using the non-linear model were therefore more accurate and were found to have a smaller bias than those estimated using the linear model.
日本医療薬学会の論文
1997-04-10