Possible Origin of Rat Testicular Atrophy Induced by Di-n-Butyl Phthalate : Changes in the Activities of Some Enzymes during Rat Testis Perfusion under a Hypoxic Condition and with Mono-n-Butyl Phthalate
スポンサーリンク
概要
- 論文の詳細を見る
To examine whether testicular toxicity in rats is caused by a direct effect of mono-butyl phthalate (MBP), a metabolite of di-butyl phthalate, or by a secondary effect attributed to a hypoxic condition due to the MBP-induced hemoglobin deprivation, the testes were perfused with a solution of MBP in Eagle's MEM or the MEM with/without oxygen, and the activities of testicular enzymes were measured. A decrease in the succinate dehydrogenase (SUDH) activity was observed by the hypoxic perfusate [20-30% dissolved oxygen (DO)], and an induction of apoptosis was observed by the 7% DO perfusate. However, the 100 mM MBP perfusate decreased the activity of SUDH per testis weight, but not per protein level. Therefore, this study proposes that the toxicity might be caused by hypoxia and a coincident depletion of SUDH activity, followed by an apoptotic testicular cell death.
- 公益社団法人日本薬学会の論文
- 2002-12-01
著者
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松本 宜明
日本大学薬学部臨床薬物動態学ユニット
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SHIMIZU Makiko
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
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MATSUMOTO Yoshiaki
Department of Clinical Pharmacology and Toxicology, Showa College of Pharmaceutical Sciences
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FUKUOKA Masamichi
Department of Clinical Pharmacology and Toxicology, Showa College of Pharmaceutical Sciences
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Matsumoto Y
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Watanabe Nobuo
Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Sci
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Fujii M
Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences
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Fujii Makiko
Department Of Pharmaceutics Showa College Of Pharmaceutical Science
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Watanabe N
Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto
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SHIMIZU Makiko
Department of Clinical Pharmacology and Toxicology, Showa Pharmaceutical University
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Shimizu Makiko
Showa Pharmaceutical University
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Shimizu M
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Shimizu Makiko
Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.
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Shimizu Makiko
Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University
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Shimizu Makiko
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Fujii M
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Matsumoto Yoshiaki
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Fukuoka Masamichi
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Fukuoka Masamichi
Division Of Medical Chemistry National Institute Of Hygienic Sciences
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Matsumoto Yoshiaki
Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences
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松本 宣明
Division Of Applied Life Science Graduate School Of Engineering Sojo University
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Fukuoka M
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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Saito Miwako
Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.
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Matsumoto Yoshiaki
Department Of Clinical Pharmacokinetics College Of Pharmacy Nihon University
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