日本人肝におけるフラビン含有モノオキシゲナーゼ3発現の個人差 : 肝転写因子との相関
スポンサーリンク
概要
- 論文の詳細を見る
- 2009-06-25
著者
-
Yamazaki Hiroshi
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
-
GUENGERICH F.
Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medic
-
SHIMIZU Makiko
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
-
MURAYAMA Norie
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
-
NAGASHIMA Satomi
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
-
Murayama Norie
Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University
-
Murayama Norie
昭和薬科大学 薬物動態学研究
-
Guengerich F.
Department Of Biochemistry And Center In Molecular Toxicology Vanderbilt University School Of Medici
-
YANO Hiroshi
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
-
KUMAI Toshio
St. Marianna University School of Medicine
-
KOBAYASHI Shinichi
St. Marianna University School of Medicine
-
Murayama Norie
Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.
-
Shimizu Makiko
Showa Pharmaceutical University
-
Shimizu M
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
-
Shimizu Makiko
Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.
-
Shimizu Makiko
Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University
-
Shimizu Makiko
Laboratory For Genetics Of Allergic Diseases Snp Research Center Riken
-
Saito Miwako
Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.
-
Yamazaki Hiroshi
Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University
-
Nagashima Satomi
Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University
関連論文
- Genotoxic Activation of the Environmental Pollutant 3-Nitrobenzanthrone by Human Cytochrome P450 Enzymes Expressed in Salmonella typhimurium umu Tester Strains
- Human blood concentrations of dichlorodiphenyltrichloroethane (DDT) extrapolated from metabolism in rats and humans and physiologically based pharmacokinetic modeling
- 新規CYP2A6遺伝子多型のハプロタイプおよび機能解析
- 肝P450等の薬物代謝酵素活性を指標とした日本発新規ヒト型モデル動物"マイクロミニブタ"の非臨床試験における高い将来性
- 日本人肝におけるフラビン含有モノオキシゲナーゼ3発現の個人差 : 肝転写因子との相関
- Complex Mechanism Underlying Transcriptional Control of the Haplotyped Flavin-containing Monooxygenase 3 (FMO3) Gene in Japanese : Different Regulation between Mutations in 5'-Upstream Distal Region and Common Element in Proximal Region
- Sulfating-Activity and Stability of cDNA-Expressed Allozymes of Human Phenol Sulfotransferase, ST1A31 (^Arg) and ST1A32 (^His), Both of Which Exist in Japanese as Well as Caucasians^1
- 高気圧酸素療法を施した患者の抗がん薬カルボプラチン血漿中濃度測定用HPLC法について
- Drug metabolism and toxicity in chimeric mice with humanized liver
- Missense and Nonsense Mutations of the Flavin-containing Monooxygenase 3 Gene in a Japanese Cohort
- Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population.
- 日本人トリメチルアミン尿症の原因となるフラビン含有モノオキシゲナーゼ3遺伝子の新規遺伝子変異
- Two Novel Single Nucleotide Polymorphisms (SNPs) of the FMO3 Gene in Japanese
- Human Blood Concentrations of Dichlorodiphenyltrichloroethane (DDT) Extrapolated from Metabolism in Rats and Humans and Physiologically Based Pharmacokinetic Modeling
- Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome: Development of Chronic Atrioventricular Block Model of Microminipig
- Drug Metabolism and Toxicity in Chimeric Mice with Humanized Liver
- Pharmacokinetic Investigation of Increased Efficacy Against Malignant Gliomas of Carboplatin Combined With Hyperbaric Oxygenation
- Correlation between the Physicochemical Property of Some Nonsteroidal Anti-inflammatory Drugs and Changes in Adenosine Triphosphate, Glutathione and Hemoglobin in Rat Erythrocytes(Biopharmacy)
- Twenty One Novel Single Nucleotide Polymorphisms (SNPs) of the CYP2A6 Gene in Japanese and Caucasians
- Activities of Cytochrome P450 Enzymes in Liver and Kidney Microsomes from Systemic Carnitine Deficiency Mice with a Gene Mutation of Carnitine / Organic Cation Transporter
- Association of the RIP2 Gene with Childhood Atopic Asthma
- Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma
- CYP3A5 Contributes Significantly to CYP3A-mediated Drug Oxidations in Liver Microsomes from Japanese Subjects
- Evaluation of Pharmacokinetic parameters of Cibenzoline after Administration of a Single Oral Dose in Healthy Volunteers
- Evaluation of Pharmacokinetic Parameters of Cibenzoline after Administration of a Single Oral Dose in Healthy Volunteers
- In vivo Evaluation of Coumarin and Nicotine as Probe Drugs to Predict the Metabolic Capacity of CYP2A6 Due to Genetic Polymorphism in Thais
- Novel Nonsynonymous Polymorphisms of the CYP1A1 Gene in Japanese
- Toxicological roles of human and rodent CYP2As in the mutagenic activation of N-nitrosamines.(GENERAL SESSION BY ORAL PRESENTATION)(DRUG METABOLISM)
- Novel Mutations of the CYP2A6 Gene in a Thai Population with Lowered Capacity of Coumarin 7-Hydroxylation
- Two Novel Haplotypes of CYP2D6 Gene in a Japanese Population
- Eighteen Novel Polymorphisms of the CYP2A13 Gene in Japanesse
- An association study of asthma and related phenotypes with polymorphisms in negative regulator molecules of the TLR signaling pathway
- ラット肝臓ミクロソームにおける, 硫酸マグネシウムによるチトクロームP450 2C, 3Aの活性化およびブピバカインの酸化代謝に及ぼす影響
- Population Pharmacokinetic-Pharmacodynamic Modeling of TF-505 Using Extension of Indirect Response Model by Incorporating a Circadian Rhythm in Healthy Volunteers(Biopharmacy)
- 4'-Hydroxylation of Flurbiprofen by Rat Liver Microsomes in Fasting and Feeding Conditions(Biopharmacy)
- Effects of Aspirin and/or Salicylate on Hydrolysis and Glucuronidation of Indomethacin in Rat Erythrocytes and Hepatocytes
- Glucuronidation of Propofol and Its Analogs by Human and Rat Liver Microsomes
- Testicular Toxicity of Mono-n-Butyl Phthalate and Related Phthalates on Bound Iron in Rat Red Blood Cells
- Possible Origin of Rat Testicular Atrophy Induced by Di-n-Butyl Phthalate : Changes in the Activities of Some Enzymes during Rat Testis Perfusion under a Hypoxic Condition and with Mono-n-Butyl Phthalate
- A Computer Program for Pharmacokinetics Based on Maximum Likelihood Estimation Using the Gamma Distribution with a Probability Density Function : Comparison with the Normal Distribution
- Blood Concentrations of 1,4-Dioxane in Humans after Oral Administration Extrapolated from In Vivo Rat Pharmacokinetics, In Vitro Human Metabolism, and Physiologically Based Pharmacokinetic Modeling
- Comparison of the Contributions of Cytochromes P450 3A4 and 3A5 in Drug Oxidation Rates and Substrate Inhibition
- AN ENZYMIC MECHANISM FOR MUTAGENIC ACTIVATION OF CARCINOGENIC AMINOAZO DYES
- Species Difference between Cynomolgus Monkeys and Humans on Cytochromes P450 2D and 3A-Dependent Drug Oxidation Activities in Liver Microsomes
- Bonitos with Low Content of Malodorous Trimethylamine as Palliative Care for Self-reported Japanese Trimethylaminuria Subjects
- Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system(CELL AND TISSUE ENGINEERING)
- CYP1B1 is polymorphic in cynomolgus and rhesus macaques
- Cynomolgus Macaque CYP4 Isoforms Are Functional, Metabolizing Arachidonic Acid
- Dose-dependent Effects of Cigarette Smoke on Blood Biomarkers in Healthy Japanese Volunteers : Observations from Smoking and Non-smoking
- Identification and Characterization of CYP2C18 in Cynomolgus Macaque (Macaca fascicularis)
- Identification and Characterization of CYP2B6 cDNA in Cynomolgus Macaques (Macaca fascicularis)
- A Major Genotype in UDP-glucuronosyltransferase 2B15
- Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research : In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome : Development of Chronic Atrioventricular Block Model of Microminipig
- Evaluation of cytotoxic potential of cored soft contact lenses with adsorbed active ingredients from over-the-counter eye drops
- Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway
- Molecular Cloning, Functional Expression, and Characterization of Isolectin Genes of Hemolytic Lectin CEL-III from the Marine Invertebrate Cucumaria echinata
- Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs