Eighteen Novel Polymorphisms of the CYP2A13 Gene in Japanesse

スポンサーリンク

概要

• 論文の詳細を見る
• 2003-04-14

著者

• Yamazaki Hiroshi

  Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University

• FUJIEDA Masaki

  Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University

• Fujieda Masaki

  Laboratory Of Drug Metabolism Graduate School Of Pharmaceutical Sciences Hokkaido University

• Fujieda M

  Laboratory Of Drug Metabolism Graduate School Of Pharmaceutical Sciences Hokkaido University

• Fujieda Masaki

  北海道大学 薬研究 代謝分析学

• Fujieda Masaki

  Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University

• Kunitoh Hideo

  北海道大学 薬研究 代謝分析学

• Kunitoh Hideo

  National Cancer Center Hospital

• Kiyotani K

  Laboratory Of Drug Metabolism Graduate School Of Pharmaceutical Sciences Hokkaido University

• Kiyotani Kazuma

  北海道大学 薬研究 代謝分析学

• Kiyotani Kazuma

  Laboratory For Pharmacogenetics Snp Research Center The Institute Of Physical And Chemical Research

• Kiyotani Kazuma

  Laboratory Of Drug Metabolism Graduate School Of Pharmaceutical Sciences Hokkaido University

• KAMATAKI Tetsuya

  Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University

• Dosaka-akita Hirotoshi

  Hokkaido University Graduate School Of Medicine

• Kamataki Tetsuya

  Laboratory Of Drug Metabolism Graduate School Of Pharmaceutical Sciences Hokkaido University

• Yamazaki H

  大阪大学 薬学研究科臨床薬効解析学分野

• MUROI Asami

  Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University

• SAWAMURA Yuichi

  Maruyama Clinic

• Yamazaki Hiroshi

  Laboratory Of Drug Metabolism Graduate School Of Pharmaceutical Sciences Hokkaido University

• Muroi Asami

  Laboratory Of Drug Metabolism Graduate School Of Pharmaceutical Sciences Hokkaido University

• Yamazaki H

  Kanazawa Univ. Kanazawa Jpn

• Funayama M

  Laboratory Of Drug Metabolism Graduate School Of Pharmaceutical Sciences Hokkaido University

• Fujieda Masaki

  Lab. Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical Univ.

• Yamazaki Hiroshi

  Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University

• Kamataki Tetsuya

  Laboratory Of Drug Metabolism Division Of Pharmacobio-dynamics Graduate School Of Pharmaceutical Sci

• Kiyotani Kazuma

  Laboratory For Pharmacogenetics Riken Center For Genomic Medicine

関連論文

• Genotoxic Activation of the Environmental Pollutant 3-Nitrobenzanthrone by Human Cytochrome P450 Enzymes Expressed in Salmonella typhimurium umu Tester Strains
• Human blood concentrations of dichlorodiphenyltrichloroethane (DDT) extrapolated from metabolism in rats and humans and physiologically based pharmacokinetic modeling
• 肝P450等の薬物代謝酵素活性を指標とした日本発新規ヒト型モデル動物"マイクロミニブタ"の非臨床試験における高い将来性
• 日本人肝におけるフラビン含有モノオキシゲナーゼ3発現の個人差 : 肝転写因子との相関
• Complex Mechanism Underlying Transcriptional Control of the Haplotyped Flavin-containing Monooxygenase 3 (FMO3) Gene in Japanese : Different Regulation between Mutations in 5'-Upstream Distal Region and Common Element in Proximal Region
• 高気圧酸素療法を施した患者の抗がん薬カルボプラチン血漿中濃度測定用HPLC法について
• Drug metabolism and toxicity in chimeric mice with humanized liver
• Missense and Nonsense Mutations of the Flavin-containing Monooxygenase 3 Gene in a Japanese Cohort
• Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population.
• 日本人トリメチルアミン尿症の原因となるフラビン含有モノオキシゲナーゼ3遺伝子の新規遺伝子変異
• Two Novel Single Nucleotide Polymorphisms (SNPs) of the FMO3 Gene in Japanese
• A Mutation in the Flavin-containing Monooxygenase 3 Gene and its Effects on Catalytic Activity for N-oxidation of Trimethylamine In Vitro
• Overexpression of CYP2A6 in human colorectal tumors
• Human Blood Concentrations of Dichlorodiphenyltrichloroethane (DDT) Extrapolated from Metabolism in Rats and Humans and Physiologically Based Pharmacokinetic Modeling
• Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome: Development of Chronic Atrioventricular Block Model of Microminipig
• O-18 Role of Human N-Acetyltransferase in the Metabolic Activation of 2-Phenylbenzotriazole (PBTA) Derivatives.(Proceedings of the 27th Annual Meeting)
• 21C-01-1 Metabolic Activation of PBTA-1 and PBTA-2 by Human Cytochrome P450 1A1.
• Cytochrome P450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver
• Establishment of in silico systems to predict the effects of genetic polymorphism on the enzymatic activity of cytochrome P450
• Drug Metabolism and Toxicity in Chimeric Mice with Humanized Liver
• Inhibitory Effects of Nicardipine to Cytochrome P450 (CYP) in Human Liver Microsomes(Biopharmacy)
• Co-operative Regulation of the Transcription of Human Dihydrodiol Dehydrogenase(DD)4/Aldo-Keot Reductase(AKR)1C4 Gene by Hepatocyte Nuclear Factor(HNF)-4α/γand HNF-1α.
• Characterization of a Novel Variant (S145C/L311V) of 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase in Human Liver.
• Factor(s) Regulating the Induction of CYP1A1 by Aryl Hydrocarbons in Rabbits
• CHARACTERIZATION OF TRANSGENIC MICE CARRYING A HUMAN FETUS-SPECIFIC CYP3A7.
• "B-9 Factors Regulating CYP1A1 Induction in Adult Rabbit Livers.
• Impact of CYP2D6^*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy
• Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia
• 高度の死体損壊を伴った幼児遺棄死体の剖検例
• 乳幼児突然死症候群の肺サ-ファクタント所見〔英文〕
• 乳幼児突然死症候群と睡眠体位に関する最近の話題
• Pharmacokinetic Investigation of Increased Efficacy Against Malignant Gliomas of Carboplatin Combined With Hyperbaric Oxygenation
• Inhibiton by EGCG of benzo[a]pyrene-induced mutations in the lung of HITEC mice.
• CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers.(GENERAL SESSION BY ORAL PRESENTATION)(DRUG METABOLISM)
• SUPPRESSION OF PPAR ALPHA SIGNAL CAUSED BY POLYCYCLIC AROMATIC HYDROCARBONS.(GENERAL SESSION BY POSTER PRESENTATION)(MOLECULAR TOXICITY & TOXICOGENOMICS)
• 2B-08 Establishment of Genetically Engineered E.coli Highly Sensitive to Nitrosamines by Introducing Human CYP2E1
• Twenty One Novel Single Nucleotide Polymorphisms (SNPs) of the CYP2A6 Gene in Japanese and Caucasians
• Activities of Cytochrome P450 Enzymes in Liver and Kidney Microsomes from Systemic Carnitine Deficiency Mice with a Gene Mutation of Carnitine / Organic Cation Transporter
• CYP3A5 Contributes Significantly to CYP3A-mediated Drug Oxidations in Liver Microsomes from Japanese Subjects
• In vivo Evaluation of Coumarin and Nicotine as Probe Drugs to Predict the Metabolic Capacity of CYP2A6 Due to Genetic Polymorphism in Thais
• Novel Nonsynonymous Polymorphisms of the CYP1A1 Gene in Japanese
• Toxicological roles of human and rodent CYP2As in the mutagenic activation of N-nitrosamines.(GENERAL SESSION BY ORAL PRESENTATION)(DRUG METABOLISM)
• Novel Mutations of the CYP2A6 Gene in a Thai Population with Lowered Capacity of Coumarin 7-Hydroxylation
• O11-15 Mutagenic activation of tobacco-related N-nitrosamines by rat CYP2As in comparison with human CYP2A6.
• O11-14 Comparison of the toxicolqical roles of mouse CYP2A with human CYP2A6.
• Genetic Polymorphism in the 5'-Flanking Region of Human CYP1A2 Gene : Effect on the CYP1A2 Inducibility in Humans
• Two Novel Haplotypes of CYP2D6 Gene in a Japanese Population
• Eighteen Novel Polymorphisms of the CYP2A13 Gene in Japanesse
• Large-scale Production of Genetically Engineered CYP3A4 in E. coli: Application of a Jarfermenter
• Establishment of Salmonella Tester Strains Co-expressing Cytochrome P450 and NADPH-cytochrome P450 Reductase.
• Application of Genetically Engineered Bacteria Carrying Human Cytochrome P450 to Toxicological Studies
• Metabolic Activation of Dimethylnitrosamine(DMN) by Human CYP2E1 Expressed in O^6-Methylguanine-DNA Methyltransferase-Deficient Cells
• Establishment Of A Salmonella Tester Strain Ultra-Sensitive To Mutagenic Heterocyclic Amines
• DEVELOPMENT OF PRACTICAL METHODS WHICH MIMIC DRUG METABOLISM IN HUMANS.
• EXPRESSION OF RECOMBINANT HUMAN CYTOCHROME P450 (P450 OR CYP) 2A6 IN ESCHERICHIA COLI.
• "S2-3 STRATEGIC PROPOSALS TO AVOID TOXIC DRUG INTERACTIONS DURING NEW DRUG DEVELOPMENT : MOLECULAR TOXICOLOGY PROPOSALS (Strategy how we can learn drug-drug interaction during the development of a new drug)
• Stable expression of CYP3A4 and CYP3A7, adult and fetal-specific forms of cytochrome P450 in human liver, in CHL cells and its application to toxicological testing.
• Effects of NO-1886 (Ibrolipim), a Lipoprotein Lipase-Promoting Agent, on Gene Induction of Cytochrome P450s, Carboxylesterases, and Sulfotransferases in Primary Cultures of Human Hepatocytes
• Blood Concentrations of 1,4-Dioxane in Humans after Oral Administration Extrapolated from In Vivo Rat Pharmacokinetics, In Vitro Human Metabolism, and Physiologically Based Pharmacokinetic Modeling
• Comparison of the Contributions of Cytochromes P450 3A4 and 3A5 in Drug Oxidation Rates and Substrate Inhibition
• Detection of Three Genetic Polymorphisms in the 5'-Flanking Region and Intron 1 of Human CYP1A2 in the Japanese Population
• Homologous Unequal Cross-Over within the Human CYP2A Gene Cluster as a Mechanism for the Deletion of the Entire CYP2A6 Gene Associated with the Poor Metabolizer Phenotype
• Association of CYP2A6 Gene Deletion with Cigarette Smoking Status in Japanese Adults
• AN ENZYMIC MECHANISM FOR MUTAGENIC ACTIVATION OF CARCINOGENIC AMINOAZO DYES
• Studies on the Interactions between Drug and Estrogen. II. On the Inhibitory Effect of 29 Drugs Reported to Induce Gynecomastia on the Oxidation of Estradiol at C-2 or C-17
• Species Difference between Cynomolgus Monkeys and Humans on Cytochromes P450 2D and 3A-Dependent Drug Oxidation Activities in Liver Microsomes
• Bonitos with Low Content of Malodorous Trimethylamine as Palliative Care for Self-reported Japanese Trimethylaminuria Subjects
• Production of Inhibitory Polyclonal Antibodies against Cytochrome P450s
• Relative Reactivity of Phenols and Formation of Phenolic Co-condensed Resins
• W1-2 Toxicological Significance of Genetic Polymorphism of Cytochrome P450 : Genetic Polymorphism of CYP2A6 and Lung Cancer Risk.(Proceedings of the 27th Annual Meeting)
• 21C-01-2 Relationship Between Genetic Polymorphism of CYP2A6 and Lung Cancer Risk.
• Separation of microsomal cytochrome b_5 via phase separation in a mixed solution of Triton X-114 and charged dextran
• Selective Solubilization of Microsomal Electron-Transfer Proteins with Alkylglucoside
• 21WA-04-2 Regulation of NAD(P)H: quinone oxidoreductase_1 (NQO_1) Gene Expression in Guinea Pig.
• Metabolism of Selegiline Hydrochloride, a Selective Monoamine B-type Inhibitor, in Human Liver Microsomes
• Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system(CELL AND TISSUE ENGINEERING)
• CYP1B1 is polymorphic in cynomolgus and rhesus macaques
• Cynomolgus Macaque CYP4 Isoforms Are Functional, Metabolizing Arachidonic Acid
• Dose-dependent Effects of Cigarette Smoke on Blood Biomarkers in Healthy Japanese Volunteers : Observations from Smoking and Non-smoking
• Novel High Performance ansa-Zirconocene Catalysts for Isospecific Polymerization of Propylene
• Synthesis of μ-Oxo Complexes of Group 4 Bridged-Metallocenes : A Convenient Separation of meso and racemo Isomers
• Polymerization of Propylene by Nonbridged Zirconocene Complexes
• Association of CYP2A6 Gene Deletion with Cigarette Smoking Status in Japanese Adults
• Identification and Characterization of CYP2C18 in Cynomolgus Macaque (Macaca fascicularis)
• Identification and Characterization of CYP2B6 cDNA in Cynomolgus Macaques (Macaca fascicularis)
• Unprecedented Rhodium-Mediated Tetramerization of Bulky Terminal Alkynes Leading to Hydropentalenylrhodium Complexes
• Dimerization of Ethynylcyclopentadienylmetal Complexes
• 虐待後に急死した乳児の剖検死因が吐物吸引であった一例
• A Major Genotype in UDP-glucuronosyltransferase 2B15
• Genetically Engineered Bacterial Cells Co-expressing Human Cytochrome P450 with NADPH-cytochrome P450 Reductase : Prediction of Metabolism and Toxicity of Drugs in Humans
• Cell-specific transcriptional regulation of the human CYP1B1 (DRUG METABOLISM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research : In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome : Development of Chronic Atrioventricular Block Model of Microminipig
• Evaluation of cytotoxic potential of cored soft contact lenses with adsorbed active ingredients from over-the-counter eye drops
• Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway
• Molecular Cloning, Functional Expression, and Characterization of Isolectin Genes of Hemolytic Lectin CEL-III from the Marine Invertebrate Cucumaria echinata
• Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients
• Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs

もっと見る 閉じる

スポンサーリンク