AN ENZYMIC MECHANISM FOR MUTAGENIC ACTIVATION OF CARCINOGENIC AMINOAZO DYES
スポンサーリンク
概要
著者
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Yamazaki Hiroshi
Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
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Tamura K
Department Of Pathology Gifu University School Of Medicine
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HIRANO Kazuyuki
Department ofPharmaceutics, Glfu Pharmaceutical University
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MORI Yukio
Gifu Pharmaceutical University
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Morishita Y
Institute Of Biological Pharmacy Gifu Pharmaceutical University
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Mori Yukio
Institute Of Biological Pharmacy Gifu Pharmaceutical University
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Morishita Y
First Department Of Pathology Gifu University School Of Medicine
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Kojima T
First Department Of Pathology Gifu University School Of Medicine
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Kinouchi T
Univ. Tokushima School Of Medicine Tokushima Jpn
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MORI Yukio
Laboratory of Radiochemistry, Gifu Pharmaceutical University
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Kaneshiro Tatsuya
琉球大学 医学部病理学第1
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Toyoshi Kazumi
Department Of Pathology Gifu University School Of Medicine
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Kinjo Tatsuya
琉球大学 医学部病理学第1
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Mori Yukio
Laboratory Of Radiochemistry Gifu Pharmaceutical University
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Kumo Toshiya
First Department Of Pathology Gifu University School Of Medicine
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Tamura Kazutoshi
Department Of Oncological Pathology Cancer Center Nara Medical University
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Hirano Kazuyuki
Radioisotope Laboratory And Department Of Pharmaceutics Gifu Pharmaceutical University
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NI-I HIROAKI
Laboratory of Radiochemistry, Gifu Pharmaceutical University
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TOYOSHI KAZUMI
Laboratory of Radiochemistry, Gifu Pharmaceutical University
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Kinouchi Takemi
Department Of Bacteriology School Of Medicine The University Of Tokushima
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Hirano Kazuyuki
Department Of Material Chemistry Graduate School Of Engineering Kyoto University
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Hirano Kazuyuki
Department Of Pharmaceutcs Gifu Pharmaceutical University
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Yoshimoto M
Department Of Oncological Pathology Cancer Center Nara Medical University
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Kinjo Tatsuya
Tumor Pathology University Of Ryukyus Faculty Of Medicine
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Kinjo Tatsuya
Department Of Molecular Bacteriology Graduate School Of Medicine The University Of Tokushima
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Yamazaki Hiroshi
Laboratory Of Drug Metabolism And Pharmacokinetics Showa Pharmaceutical University
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Kuwahara Tomomi
Department Of Bacteriology School Of Medicine The University Of Tokushima
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Yoshimoto Masatoshi
Surgical Center Nara Medical University Hospital
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Kinouchi Takemi
Department Of Molecular Bacteriology Graduate School Of Medicine The University Of Tokushima
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Kawamori Toshihiko
Department Of Pathology Gifu University School Of Medicine
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Toyoshi Kazumi
Gifu Collgege Of Pharmacy
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Mizumoto Yasushi
Surgical Center Nara Medical University Hospital
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HIRANO Kazuyuki
Department of Clinical Chemistry School of Health Sciences, Fujita Health University
関連論文
- Genotoxic Activation of the Environmental Pollutant 3-Nitrobenzanthrone by Human Cytochrome P450 Enzymes Expressed in Salmonella typhimurium umu Tester Strains
- Human blood concentrations of dichlorodiphenyltrichloroethane (DDT) extrapolated from metabolism in rats and humans and physiologically based pharmacokinetic modeling
- 肝P450等の薬物代謝酵素活性を指標とした日本発新規ヒト型モデル動物"マイクロミニブタ"の非臨床試験における高い将来性
- 日本人肝におけるフラビン含有モノオキシゲナーゼ3発現の個人差 : 肝転写因子との相関
- Complex Mechanism Underlying Transcriptional Control of the Haplotyped Flavin-containing Monooxygenase 3 (FMO3) Gene in Japanese : Different Regulation between Mutations in 5'-Upstream Distal Region and Common Element in Proximal Region
- Gastric Tumorigenicity of 1,2-Dimethylhydrazine on the Background of Gastric Intestinal Metaplasia Induced by X-Irradiation in CD (SD) Rats
- Histological and immunohistochemical observations of mucin-depleted foci (MDF) stained with Alcian blue, in rat colon carcinogenesis induced with 1, 2-dimethylhydrazine dihydrochloride
- Tumor formation is correlated with expression of β-catenin-accumulated crypts in azoxymethane-induced colon carcinogenesis in mice
- Inhibitory effects of troglitazone, a peroxisome proliferator-activated receptor γ ligand, in rat tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide
- Carcinoid tumor in the female urethral orifice : Rare case report and a review of the literature
- Induction of Apoptosis by Sulindac in Azoxymethane-induced Possible Colonic Premaligmant Lesions in Rats
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- Dietary Prevention of Azoxymethane-Induced Colon Carcinogenesis with Rice-Germ in F344 Rats.
- Suppressive Effects of S-Methyl Methanethiosulfonate on Promotion Stage of Diethylnitrosamine-initiated and Phenobarbital-promoted Hepatocarcinogenesis Model
- Inhibitory Effect of Chlorophyllin on Diethylnitrosamine and Phenobarbital-induced Hepatocarcinogenesis in Male F344 Rats
- Chemopreventive Effects of Taurine on Diethylnitrosamine and Phenobarbitalinduced Hepatocarcinogenesis in Male F344 Rats
- A Xanthine Oxiedase Inhibitor 1'-Acetoxychavicol Acetate Inhibits Azoxymethane-induced Colonic Aberrant Crypt Foci in Rats.
- Chemopreventive Effect of a Xanthine Oxidase Inhibitor, l'-Acetoxychavicol Acetate, on Rat Oral Carcinogenesis.
- Inhibitory effect of dietary monoglucosylceramide 1-O-β-glucosyl-N-2'-hydroxyarachidoyl-4,8-sphingadienine on two different categories of colon preneoplastic lesions induced by 1,2-dimethylhydrazine in F344 rats
- Chemopreventive Effect of a Xanthine Oxidase Inhibitor, 1'-Acetoxychavicol Acetate, on Rat Oral Carcinogenesis
- Genetic Variation in 16S-23S rDNA Internal Transcribed Spacer Regions and the Possible Use of This Genetic Variation for Molecular Diagnosis of Bacteroides Species
- Protective Effects of a Culture Supernatant of Lactobacillus acidophilus and Antioxidants on Ileal Ulcer Formation in Rats Treated with a Nonsteroidal Antiinflammatory Drug
- Culture Supernatants of Lactobacillus acidophilus and Bifidobacterium adolescentis Repress Ileal Ulcer Formation in Rats Treated with a Nonsteroidal Antiinflammatory Drug by Suppressing Unbalanced Growth of Aerobic Bacteria and Lipid Peroxidation
- Rapid Species Identification and Partial Strain Differentiation of Clostridium butyricum by PCR Using 16S-23S rDNA Intergenic Spacer Regions
- Suppression of Occurrence and Advancement of β-Catenin-accumulated Crypts, Possible Premalignant Lesions of Colon Cancer, by Selective Cyclooxygenase-2 Inhibitor, Celecoxib
- Mutagenic activation of N-nitrosobis(2-oxopropyl)amine by pancreatic juice and assessment of its ductal tumorigenicity following intraductal administration in dogs.
- Inhibitory Effects of Dietary Protocatechuic Acid and Costunolide on 7,12-Dimethylbenz[a ]anthracene-induced Hamster Cheek Pouch Carcinogenesis
- Inhibitory effects of sulfation inhibitors on initiation of pancreatic ductal carcinogenesis by N-nitrosobis(2-oxopropyl)amine in hamsters.
- Suppression of Azoxymethane-induced Rat Colon Carcinogenesis by Dietary Administration of Naturally Occurring Xanthophylls Astaxanthin and Canthaxanthin During the Postinitiation Phase.
- Chemoprevention of Urinary Bladder Carcinogenesis by the Natural Phenolic Compound Protocatechuic Acid in Rats.
- Chemoprevention of Azoxymethane-induced Colon Carcinogenesis by Dietary Feeding of S-Methyl Methane Thiosulfonatein Male F344 Rats.
- Suppression of Azoxymethane-induced Colonic Aberrant Crypt Foci by Dietary Exposure to a Novel Synthesized Retinoidal Butenolide, 5-Hydroxy-4-(2-phenyl-(E)ethenyl)-2(5H)-furanone, in Rats.
- Modifying Effects of Naturally Occurring Products on the Development of Colonic Aberrant Crypt Foci Induced by Azoxymethane in F344 Rats.
- Antimutagenicity of Murdannia Loriformis in the Salmonella mutation assay and its inhibitory effects on azoxmethaneinduced DNA methylation and aberrant crypt focus formation in male F344 rats
- Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethaneinduced DNA methylation and aberrant crypt focus formation in male F344 rats
- Drug metabolism and toxicity in chimeric mice with humanized liver
- Missense and Nonsense Mutations of the Flavin-containing Monooxygenase 3 Gene in a Japanese Cohort
- Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population.
- 日本人トリメチルアミン尿症の原因となるフラビン含有モノオキシゲナーゼ3遺伝子の新規遺伝子変異
- Two Novel Single Nucleotide Polymorphisms (SNPs) of the FMO3 Gene in Japanese
- Human Blood Concentrations of Dichlorodiphenyltrichloroethane (DDT) Extrapolated from Metabolism in Rats and Humans and Physiologically Based Pharmacokinetic Modeling
- Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome: Development of Chronic Atrioventricular Block Model of Microminipig
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- Variable Glyceryl Dinitrate Formation as a Function of Glutathione S-Transferase
- Inhibition of Purified Human Sucrase and Isomaltase by Ethanolamine Derivatives
- Genotoxicity of a Variety of Azobenzene and Aminoazobenzene Compounds in the Hepatocyte/DNA Repair Test and the Salmonella/Mutagenicity Test.
- Activation of Carcinogenic N-Nitrosopropylamines to Mutagens by Lung and Pancreas S9 Fractions from Various Animal Species and Man.
- A Comparative Study of the Mutagenic Activation of N-Nitrosopropylamines by Various Animal Species and Man : Evidence for a Cytochrome P-450 Dependent Reaction.
- Mutagenic Activation of Carcinogenic N-Nitrosopropylamines by Liver S9 Fractions from Mice, Rats, and Hamsters : Evidence for a Cytochrome P-450 Dependent Reaction.
- Role of Alkaline Phosphatase in Phosphate Uptake into Brush Border Membrane Vesicles from Human Intestinal Mucosa.
- In Vitro Synthesis of Superoxide Dismutases of Rat Liver.
- Species Differences in the Metabolism of Suprofen in Laboratory Animals and Man.
- POLYMORPHISM OF EXTRACELLULAR SUPEROXIDE DISMUTASE (EC-SOD) GENE : RELATION TO THE MUTATION RESPONSIBLE FOR HIGH EC-SOD LEVEL IN SERUM
- INHIBITION OF HUMAN DIPEPTIDASES BY β-LACTAM ANTIBIOTICS
- EFFECT OF SUPEROXIDE DISMUTASE ON RATS INDUCED KIDNEY INTOXICATION
- SUPEROXIDE DISMUTASE LEVELS FOLLOWING LIVER AND KIDNEY INTOXICATION
- RELATION BETWEEN CARDIOTOXIC EFFECT OF ADRIAMYCIN AND SUPEROXIDE DISMUTASE
- Pharmacokinetic Investigation of Increased Efficacy Against Malignant Gliomas of Carboplatin Combined With Hyperbaric Oxygenation
- Heparin-Induced Release of Extracellular-Superoxide Dismutase Form (V) to Plasma
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- Activities of Cytochrome P450 Enzymes in Liver and Kidney Microsomes from Systemic Carnitine Deficiency Mice with a Gene Mutation of Carnitine / Organic Cation Transporter
- CYP3A5 Contributes Significantly to CYP3A-mediated Drug Oxidations in Liver Microsomes from Japanese Subjects
- METABOLIC ACTIVATION OF N-NITROSOBIS (2-HYDROXYPROPYL) AMINE BY RATS
- In vivo Evaluation of Coumarin and Nicotine as Probe Drugs to Predict the Metabolic Capacity of CYP2A6 Due to Genetic Polymorphism in Thais
- Novel Nonsynonymous Polymorphisms of the CYP1A1 Gene in Japanese
- Toxicological roles of human and rodent CYP2As in the mutagenic activation of N-nitrosamines.(GENERAL SESSION BY ORAL PRESENTATION)(DRUG METABOLISM)
- Novel Mutations of the CYP2A6 Gene in a Thai Population with Lowered Capacity of Coumarin 7-Hydroxylation
- Two Novel Haplotypes of CYP2D6 Gene in a Japanese Population
- Eighteen Novel Polymorphisms of the CYP2A13 Gene in Japanesse
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- Comparison of the Contributions of Cytochromes P450 3A4 and 3A5 in Drug Oxidation Rates and Substrate Inhibition
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- Genotoxicity of Carcinogenic N-Nitrosopropylamine Derivatives in the Hepatocyte Primary Culture/DNA-Repair Test.
- Inhibitory Effect of Organic Solvents on the Mutagenicity of N-Nitrosodialkylamines in Salmonella.
- Mutagenic Activation of Carciuogenic N-Nitrosopropylamines by Rat Liver : Evidence for a Cytochrome P-450 Dependent Reaction.
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- An Arginine-213 to Glycine Mutation in Human Extracellular-Superoxide Dismutase Reduces Susceptibility to Trypsin-Like Proteinases
- The Effect of Ethanolamine on Acute Carbon Tetrachloride Intoxication
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- Regulators for Blood Glucose Level Affect Gene Expression of Aquaporin 3(Biopharmacy)
- Selection of Mobile Phase in High-Performance Liquid Chromatographic Determination for Medicines
- AN ENZYMIC MECHANISM FOR MUTAGENIC ACTIVATION OF CARCINOGENIC AMINOAZO DYES
- Structural Features and Hypoglycemic Activity of a Polysaccharide (CS-F10) from the Cultured Mycelium of Cordyceps sinensis
- Activation of Macrophages and Neutrophils by an Endothelium Growth Suppressing Factor
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- Purification of a Growth-Suppressing Factor for Bovine Artery Endothelial Cells from Mouse Lymphoma P388D1 Cells
- MOLECULAR ANALYSIS OF EXTRACELLULAR-SUPEROXIDE DISMUTASE GENE ASSOCIATED WITH HIGH LEVEL IN SERUM
- Species Difference between Cynomolgus Monkeys and Humans on Cytochromes P450 2D and 3A-Dependent Drug Oxidation Activities in Liver Microsomes
- Bonitos with Low Content of Malodorous Trimethylamine as Palliative Care for Self-reported Japanese Trimethylaminuria Subjects
- Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system(CELL AND TISSUE ENGINEERING)
- Cynomolgus Macaque CYP4 Isoforms Are Functional, Metabolizing Arachidonic Acid
- Dose-dependent Effects of Cigarette Smoke on Blood Biomarkers in Healthy Japanese Volunteers : Observations from Smoking and Non-smoking
- Identification and Characterization of CYP2C18 in Cynomolgus Macaque (Macaca fascicularis)
- Identification and Characterization of CYP2B6 cDNA in Cynomolgus Macaques (Macaca fascicularis)
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