METABOLIC ACTIVATION OF N-NITROSOBIS (2-HYDROXYPROPYL) AMINE BY RATS

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概要

• 論文の詳細を見る
• 公益社団法人日本薬学会の論文

著者

• Tamura K

  Department Of Pathology Gifu University School Of Medicine

• Konishi Y

  Department Of Oncological Pathology Cancer Center Nara Medical University

• MORI Yukio

  Gifu Pharmaceutical University

• Morishita Y

  Institute Of Biological Pharmacy Gifu Pharmaceutical University

• Mori Yukio

  Institute Of Biological Pharmacy Gifu Pharmaceutical University

• Morishita Y

  First Department Of Pathology Gifu University School Of Medicine

• Takahashi Hidehisa

  Gifu Pharmaceutical University:tokyo College Of Pharmacy:nara Medical College

• Kojima T

  First Department Of Pathology Gifu University School Of Medicine

• Kinouchi T

  Univ. Tokushima School Of Medicine Tokushima Jpn

• Kaneshiro Tatsuya

  琉球大学 医学部病理学第1

• Toyoshi Kazumi

  Department Of Pathology Gifu University School Of Medicine

• Kinjo Tatsuya

  琉球大学 医学部病理学第1

• Horie Masanobu

  Tokyo College Of Pharmacy

• KOTAKE Yashige

  Oklahoma Medical Research Foundation

• TOYOSHI KAZUMI

  Gifu Pharmaceutical University

• Kobayashi Y

  International Federation Of Societies Of Toxicologic Pathologists

• Konishi Yoichi

  Gifu Pharmaceutical University:nara Medical University

• Kumo Toshiya

  First Department Of Pathology Gifu University School Of Medicine

• Tamura Kazutoshi

  Department Of Oncological Pathology Cancer Center Nara Medical University

• YAMAZAKI HIROSHI

  Gifu Pharmaceutical University

• HORIE MASANOBU

  Gifu Pharmaceutical University

• BABA SHIGEO

  Gifu Pharmaceutical University

• Kinouchi Takemi

  Department Of Bacteriology School Of Medicine The University Of Tokushima

• Toyoshi Kazumi

  First Department Of Pathology Gifu University School Of Medicine

• Yoshimoto M

  Department Of Oncological Pathology Cancer Center Nara Medical University

• Kinjo Tatsuya

  Tumor Pathology University Of Ryukyus Faculty Of Medicine

• Kinjo Tatsuya

  Department Of Molecular Bacteriology Graduate School Of Medicine The University Of Tokushima

• Kuwahara Tomomi

  Department Of Bacteriology School Of Medicine The University Of Tokushima

• Yoshimoto Masatoshi

  Surgical Center Nara Medical University Hospital

• Kinouchi Takemi

  Department Of Molecular Bacteriology Graduate School Of Medicine The University Of Tokushima

• Konishi Yoichi

  Oklahoma Medical Research Foundation

• Kawamori Toshihiko

  Department Of Pathology Gifu University School Of Medicine

• Toyoshi Kazumi

  Gifu Collgege Of Pharmacy

• Mizumoto Yasushi

  Surgical Center Nara Medical University Hospital

• TOYOSHI Kazumi

  Gifu College of Pharmacy

関連論文

• Modification by curcumin of mutagenic activation of carcinogenic N-nitrosamines by extrahepatic cytochromes P-450 2B1 and 2E1 in rats
• Lack of a Dose-response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-Nitrosodiethylamine
• Histological and immunohistochemical observations of mucin-depleted foci (MDF) stained with Alcian blue, in rat colon carcinogenesis induced with 1, 2-dimethylhydrazine dihydrochloride
• Tumor formation is correlated with expression of β-catenin-accumulated crypts in azoxymethane-induced colon carcinogenesis in mice
• Inhibitory effects of troglitazone, a peroxisome proliferator-activated receptor γ ligand, in rat tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide
• Carcinoid tumor in the female urethral orifice : Rare case report and a review of the literature
• Induction of Apoptosis by Sulindac in Azoxymethane-induced Possible Colonic Premaligmant Lesions in Rats
• Enhancement by Cigarette Smoke Exposure of 2-Amino-3,8-dimethylimidazo [4,5-f] quinoxaline-induced Rat Hepatocarcinogenesis in Close Association with Elevation of Hepatic CYP1A2
• Absence of mutagenic action of 5β-cholan-24-oic acid derivatives in the bacterial fluctuation and standard Ames tests.
• Common Duct Carcinoma and Obstruction in Female Hamsters Treated with N-Nitrosobis(2-oxopropyl)amine and/or Cholecystectomy.
• Dietary Prevention of Azoxymethane-Induced Colon Carcinogenesis with Rice-Germ in F344 Rats.
• Regressive Effects of Various Chemopreventive Agents on Azoxymethane-induced Aberrant Crypt Foci in the Rat Colon
• Suppressive Effects of S-Methyl Methanethiosulfonate on Promotion Stage of Diethylnitrosamine-initiated and Phenobarbital-promoted Hepatocarcinogenesis Model
• Inhibitory Effect of Chlorophyllin on Diethylnitrosamine and Phenobarbital-induced Hepatocarcinogenesis in Male F344 Rats
• Chemopreventive Effects of Taurine on Diethylnitrosamine and Phenobarbitalinduced Hepatocarcinogenesis in Male F344 Rats
• A Xanthine Oxiedase Inhibitor 1'-Acetoxychavicol Acetate Inhibits Azoxymethane-induced Colonic Aberrant Crypt Foci in Rats.
• Chemopreventive Effect of a Xanthine Oxidase Inhibitor, l'-Acetoxychavicol Acetate, on Rat Oral Carcinogenesis.
• Inhibitory effect of dietary monoglucosylceramide 1-O-β-glucosyl-N-2'-hydroxyarachidoyl-4,8-sphingadienine on two different categories of colon preneoplastic lesions induced by 1,2-dimethylhydrazine in F344 rats
• Genetic alterations in a patient with Turcot's syndrome
• CARCINOGENICITY EXAMINATION OF 1-NITROPYRENE OXIDES AND RELATED CHEMICALS : LACK OF THEIR TUMORIGENIC EFFECTS IN A NEWBORN MICE ASSAY
• Alterations of the Transforming Growth Factor-β Signaling Pathway in Hepatocellular Carcinomas Induced Endogenously and Exogenously in Rats
• Mutations and Reduced Expression of the Transforming Growth Factor-β Receptor II Gene in Rat Lung A denocarcinomas Induced by N-Nitrosobis-(2-hydroxypropyl)amine
• Elevated Expression of Interleukins in Lung Adenocarcinomas Induced by N-Nitrosobis(2-hydroxypropyl)amine in Rats
• Hypomethylation of CpG Sites and c-myc Gene Overexpression in Hepatocellular Carcinomas, but Not Hyperplastic Nodules, Induced by a Choline-deficient L-Amino Acid-defined Diet in Rats
• Increased Telomerase Activities in Human Pancreatic Duct Adenocarcinomas
• Chemopreventive Effect of a Xanthine Oxidase Inhibitor, 1'-Acetoxychavicol Acetate, on Rat Oral Carcinogenesis
• Genetic Variation in 16S-23S rDNA Internal Transcribed Spacer Regions and the Possible Use of This Genetic Variation for Molecular Diagnosis of Bacteroides Species
• Protective Effects of a Culture Supernatant of Lactobacillus acidophilus and Antioxidants on Ileal Ulcer Formation in Rats Treated with a Nonsteroidal Antiinflammatory Drug
• Culture Supernatants of Lactobacillus acidophilus and Bifidobacterium adolescentis Repress Ileal Ulcer Formation in Rats Treated with a Nonsteroidal Antiinflammatory Drug by Suppressing Unbalanced Growth of Aerobic Bacteria and Lipid Peroxidation
• Rapid Species Identification and Partial Strain Differentiation of Clostridium butyricum by PCR Using 16S-23S rDNA Intergenic Spacer Regions
• Suppression of Occurrence and Advancement of β-Catenin-accumulated Crypts, Possible Premalignant Lesions of Colon Cancer, by Selective Cyclooxygenase-2 Inhibitor, Celecoxib
• Mutagenic activation of N-nitrosobis(2-oxopropyl)amine by pancreatic juice and assessment of its ductal tumorigenicity following intraductal administration in dogs.
• Inhibitory Effects of Dietary Protocatechuic Acid and Costunolide on 7,12-Dimethylbenz[a ]anthracene-induced Hamster Cheek Pouch Carcinogenesis
• Inhibitory effects of sulfation inhibitors on initiation of pancreatic ductal carcinogenesis by N-nitrosobis(2-oxopropyl)amine in hamsters.
• Suppression of Azoxymethane-induced Rat Colon Carcinogenesis by Dietary Administration of Naturally Occurring Xanthophylls Astaxanthin and Canthaxanthin During the Postinitiation Phase.
• Chemoprevention of Urinary Bladder Carcinogenesis by the Natural Phenolic Compound Protocatechuic Acid in Rats.
• Chemoprevention of Azoxymethane-induced Colon Carcinogenesis by Dietary Feeding of S-Methyl Methane Thiosulfonatein Male F344 Rats.
• Suppression of Azoxymethane-induced Colonic Aberrant Crypt Foci by Dietary Exposure to a Novel Synthesized Retinoidal Butenolide, 5-Hydroxy-4-(2-phenyl-(E)ethenyl)-2(5H)-furanone, in Rats.
• Modifying Effects of Naturally Occurring Products on the Development of Colonic Aberrant Crypt Foci Induced by Azoxymethane in F344 Rats.
• Differences in susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis between SD/gShi rats with spontaneous hypospermatogenesis and SD/cShi rats with spontaneous hydronephrosis
• Promoting Effect of Sodium L-Ascorbate on N-Butyl-N-(4-hydroxybutyl)nitrosamine-induced Renal Pelvic Carcinogenesis in SD/cShi Rats of Both Sexes
• N-Benzylimidazole for preparation of S9 fraction with multi-induction of metabolizing enzymes in hort-term genotoxicity assays.
• Lack of changes in the levels of liver and kidney cytochrome P-450 isozymes in p53(+/-)knockout mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
• Differences among Three Sister Strains of NON/Shi Mice in Sensitivity to Urinary Tract Carcinogenesis by N-Butyl-N-(4-hydroxybutyl)nitrosamine.
• Effect of Cigarette Smoke on the Mutagenic Activation of Environmental Carcinogens by Rodent Liver.
• High Susceptibility of p53(+/-)Knockout Mice in N-Butyl-N-(4-hydroxybutyl)nitrosamine Urinary Bladder Carcinogenesis and Lack of Frequent Mutation in Residual Allele.
• Telomerase Activity Correlates with Growth of Transplantable Osteosarcomas in Rats Treated with cis-Diammine Dichloroplatinum or the Angiogenesis Inhibitor AGM-1470
• Comutagenic Effect of Bile Acids with 2-Aminoanthracene, 1,2-Dimethylhydrazine and Pancreas-carcinogenic N-Nitroso Compounds.
• Enhancement of N-nitrosodiethylamine-Initiated Hepatocarcinogenesis Caused by a Colchicine-induced Cell Cycle Disturbance in Partially Hepatectomized Rats.
• Lack of significant tumor induction by endogeneously formed N-nitrosobis(2-hydroxypropyl)amine in rats fed tris(2-hydroxypropyl)-amine and sodium nitrite.
• Effect of cigarette smoke on the mutagenic activation of various carcinogens in hamster.
• Antimutagenicity of Murdannia Loriformis in the Salmonella mutation assay and its inhibitory effects on azoxmethaneinduced DNA methylation and aberrant crypt focus formation in male F344 rats
• Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethaneinduced DNA methylation and aberrant crypt focus formation in male F344 rats
• Molecular Aspects during Multi-step Chemical Induced Carcinogenesis in the Lung and Pancreas
• Possible Involvement of Adaptation Mechanisms in the Achievement of an Ineffective Dose Range for the Carcinogenicity of Genotoxic Carcinogens
• Effects of phenyl N-tert-butyl nitrone and its derivatives on the early phase of hepatocarcinogenesis in rats fed a choline-deficient, L-amino acid-defined diet
• Development of Hepatocellular Adenomas and Carcinomas Associated with Fibrosis in C57BL/6J Male Mice Given a Choline-deficient, L-Amino Acid-defined Diet
• Inhibition of Early-phase Exogenous and Endogenous Liver Carcinogenesis in Transgenic Rats Harboring a Rat Glutathione S-Transferase Placental Form Gene
• Systemic mast cell disease with splenic infarction : A case report
• Inhibition by Green Tea Extract of Diethylnitrosamine-initiated but Not Choline-deficient, L-Amino Acid-defined Diet-associated Development of Putative Preneo-plastic, Glutathione S-Transferase Placental Form-positive Lesions in Rat Liver
• Increased Telomerase Activity in Hyperplastic Nodules and Hepatocellular Carcinomas Induced by a Choline-deficient L-Amino Acid-defined Diet in Rats
• Prevention by Methionine of Enhancement of Hepatocarcinogenesis by Coadministration of a Choline-deficient L-Amino Acid-defined Diet and Ethionine in Rats
• Association between pentosidine and arteriosclerosis in patients receiving hemodialysis
• Genotoxicity of a Variety of Azobenzene and Aminoazobenzene Compounds in the Hepatocyte/DNA Repair Test and the Salmonella/Mutagenicity Test.
• Activation of Carcinogenic N-Nitrosopropylamines to Mutagens by Lung and Pancreas S9 Fractions from Various Animal Species and Man.
• A Comparative Study of the Mutagenic Activation of N-Nitrosopropylamines by Various Animal Species and Man : Evidence for a Cytochrome P-450 Dependent Reaction.
• Mutagenic Activation of Carcinogenic N-Nitrosopropylamines by Liver S9 Fractions from Mice, Rats, and Hamsters : Evidence for a Cytochrome P-450 Dependent Reaction.
• Role of Alkaline Phosphatase in Phosphate Uptake into Brush Border Membrane Vesicles from Human Intestinal Mucosa.
• In Vitro Synthesis of Superoxide Dismutases of Rat Liver.
• Chromophobe cell renal carcinoma with acquired cystic disease of the kidney in a long-term hemodialysis patient
• Inhibitory Effect of Tomato Juice on Rat Urinary Bladder Carcinogenesis after N-Butyl-N-(4-hydroxybutyl)nitrosamine Initiation
• Shortened Telomere Length in Hepatocellular Carcinomas and Corresponding Background Liver Tissues of Patients Infected with Hepatitis Virus
• Species Differences in the Metabolism of Suprofen in Laboratory Animals and Man.
• INHIBITION OF HUMAN DIPEPTIDASES BY β-LACTAM ANTIBIOTICS
• Possible Lack of Carcinogenic Potential of 9-(4'-Aminophenyl)-9H-pyrido[3,4-b]indole (aminophenylnorharman) for the Pancreatic Duct Epithelium in Hamsters
• Branched chain amino acid in adenine-induced uremic rats treated with rHuEPO
• Generation of Metastatic Variants of Eker Renal Carcinoma Cell Lines for Experimental Investigation of Renal Cancer Metastasis
• Vascular Changes in Primary and Transplantable Pancreatic Adenocarcinomas Induced by Propylnitrosamines.
• Overexpression of Midkine in Pancreatic Duct Adenocarcinomas Induced by N-Nitrosobis(2-oxopropyl)amine in Hamsters and Their Cell Lines
• Carcinogenic activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine(BHP) in rats administered bis(2-hydroxypropyl)-amine(BHPA) and sodium nitrite(SN).
• Initiation activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine in the rat liver.
• Carcinogenic Potency of N-nitrosomethyl(2-hydroxypropyl)amine and Other Metabolic Relatives of N-Nitrosobis(2-hydroxypropyl)amine by Single Intraperitoneal Injection on the Lung of Rats.
• Mutagenesis of Isopropanolamines and Ethanolamines after Reaction with Sodium Nitrite.
• Aggressive angiomyxoma in the scrotum expressing androgen and progesterone receptors
• METABOLIC ACTIVATION OF N-NITROSOBIS (2-HYDROXYPROPYL) AMINE BY RATS
• Genotoxicity of Carcinogenic N-Nitrosopropylamine Derivatives in the Hepatocyte Primary Culture/DNA-Repair Test.
• Inhibitory Effect of Organic Solvents on the Mutagenicity of N-Nitrosodialkylamines in Salmonella.
• Mutagenic Activation of Carciuogenic N-Nitrosopropylamines by Rat Liver : Evidence for a Cytochrome P-450 Dependent Reaction.
• Inhibition of Spontaneous Rat Osteosarcoma Lung Metastasis by 3S-[4-(Nhydroxyamino)-2R-isobutylsuccinyl]-1-methoxy-3,4-dihydrocarbostyril, a Novel Matrix Metalloproteinase Inhibitor
• AN ENZYMIC MECHANISM FOR MUTAGENIC ACTIVATION OF CARCINOGENIC AMINOAZO DYES
• Effects of Isoliquirithigenin on the Development of Preneoplastic Liver Lesions Caused by a Choline-Deficient, L-Amino Acid-Defined Diet and on the Urinary Bladder Carcinogenesis by N-Butyl-N-(4-hydroxybutyl)nitrosamine in Rats
• Pathogenesis of multifocal micronodular pneumocyte hyperplasia and lymphangioleiomyomatosis in tuberous sclerosis and association with tuberous sclerosis genes TSC1 and TSC2
• Mechanistic Analysis of Pancreatic Ductal Carcinogenesis in Hamsters
• Inhibitory Effects of β-Carotene, Palm Carotene, and Green Tea Polyphenols on Pancreatic Carcinogenesis Initiated by N-Nitrosobis(2-oxopropyl)amine in Syrian Golden Hamsters
• Mutagenicity of N-Nitrosodiethanolamine in the Salmonella/Microsome Test.
• 4-Hydroxyaminoquinoline 1-0xide Metabolism and DNA Adducts in the Early Stage of Tumorigenesis in Rats : Comparison of Target Organ Pancreas with Non-Target Organ Liver.
• Serous borderline tumor of the paratestis
• A case of gastric cancer with non-islet cell tumor hypoglycemia detected by insulin-like growth factor II
• Lack of Promoting Potential of Dimethylarsinic Acid in the Kidney of Male NCI-Black Reiter Rats
• Lack of Effects of Bisphenol A in Maternal Rats or Treatment on Response of Their Offspring to N-Nitrosobis (2-hydroxypropyl)amine

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