Effects of Isoliquirithigenin on the Development of Preneoplastic Liver Lesions Caused by a Choline-Deficient, L-Amino Acid-Defined Diet and on the Urinary Bladder Carcinogenesis by N-Butyl-N-(4-hydroxybutyl)nitrosamine in Rats
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概要
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Cancer chemopreventive efficacy of a chalcone, isoliquiritigenin (ISO), was assessed on the rat hepatocarcinogenesis associated with fibrosis caused by a choline-deficient, L-amino acid-defined (CDAA) diet, using glutathione S-transferase placental form (GST-P)-positive preneoplastic foci as the end point lesion, and on the rat superficial bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). ISO, when given to F344 male rats at the doses of 12.5, 50, 100, and 200 ppm in the CDAA diet for 15 weeks, did not significantly affect the number and size of GST-P-positive foci and the % liver area occupied by the foci. However, it tended to decrease the grade of liver fibrosis. ISO, which was given in a basal diet at doses of 12.5, 25, and 100 ppm for 12 weeks to F344 male rats initiated by 0.05% BBN in drinking water for 12 weeks, also exhibited no clear chemopreventive effects on the development of urinary bladder tumors. Nevertheless, it tended to decrease the multiplicity of nodulo-papillary hyperplasia but not of transitional cell carcinoma (TCC), and differentiation grade of TCCs. The results indicate that ISO at least at the doses used in the present study, possesses no clear cancer chemopreventive efficacy on rat hepatocarcinogenesis caused by a CDAA diet and on rat superficial urinary bladder carcinogenesis by BBN.
- 2003-12-30
著者
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小西 陽一
奈良県立医科大学腫瘍病理
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小西 陽一
奈良県立医科大学・腫瘍病理学
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小西 陽一
奈良医大
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Muramatsu T
Department Of Frontier Surgery Graduate School Of Medicine Chiba University
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KONISHI Yoichi
Department of Oncological Pathology, Cancer Center, Nara Medical University
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Konishi Y
Department Of Oncological Pathology Cancer Center Nara Medical University
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Konishi Yoichi
奈良県立医科大学附属がんセンター 腫瘍病理学
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PUATANACHOKCHAI Rawiwan
Department of Pathology, Osaka City University Medical School
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TSUTSUMI Masahiro
Department of Oncological Pathology, Cancer Center, Nara Medical University
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Konishi Yoichi
International Federation Of Societies Of Toxicologic Pathologists
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DENDA Ayumi
Department of Oncological Pathology, Cancer Center, Nara Medical University
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KITAYAMA Wakashi
Department of Oncological Pathology, Cancer Center, Nara Medical University
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NISHINO Hoyoku
Department of Biochemistry, Kyoto Prefectural University of Medicine
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KUNIYASU Hiroki
Department of Molecular Pathology, Nara Medical University
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Kitayama Wakashi
Department Of Oncological Pathology Cancer Center Nara Medical University
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Nishino H
Department Of Biochemistry Kyoto Prefectural University Of Medicine
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Nishino H
Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine
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Nishino Hoyoku
Department Of Biochemistry And Molecular Biology Graduate School Of Medical Science Kyoto Prefectura
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Nishino Hoyoku
Kyoto Prefectural University Of Medicine
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Konishi Yoichi
Department Of Gastroenterology And Hepatology Shimane University School Of Medicine
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小西 陽一
奈良医大附属病院がんセンター病理
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KOTAKE Yashige
Oklahoma Medical Research Foundation
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BABA Masaki
Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University
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OKUYAMA Toru
Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University
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Muramatsu Takashi
Department Of Developmental Medicine (pediatrics) Osaka University Graduate School Of Medicine
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Muramatsu Takashi
Department Of Pediatric Dentistry School Of Dentistry Health Sciences University Of Hokkaido
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Muramatsu Takashi
Department Of Biochemistry Nagoya University School Of Medicine
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Kobayashi Y
International Federation Of Societies Of Toxicologic Pathologists
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Puatanachokchai Rawiwan
Department Of Oncological Pathology Cancer Center Nara Medical University
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Wakabayashi K
Cancer Prevention Division National Cancer Center Research Institute
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Wakabayashi Keiji
愛知県がんセンター研究所
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BABA Masaki
明治薬科大学天然薬物学教室
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Tsutsumi M
Department Of Oncological Pathology Cancer Center Nara Medical University
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Tsutsumi Masahiro
Department Of Pathology Saiseikai Chuwa Hospital
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Tsutsumi Masahiro
Department Of Oncological Pathology Cancer Center Nara Medical College
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Majima Toshimitsu
Department Of Oncological Pathology Cancer Center
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Baba Masaki
Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University
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Demda Ayumi
Department Of Oncological Pathology Cancer Center Nara Medical University
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Okuyama Toru
Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University
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Okuyama T
Department Of Natural Medicine & Phytochemistry Meiji Pharmaceutical University
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Kuniyasu Hiroki
Department Of Molecular Pathology Nara Medical University
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Konishi Y
Nara Medical Univ. Nara Jpn
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Yoshida Katsunori
Department Of Urology Nara Prefectural Mimuro Hospital
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Wakabayashi K
Cancer Prevention Basic Research Project National Cancer Center Research Institute
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Denda Ayumi
Department Of Oncological Pathology Cancer Center Nara Medical University
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Kagebayashi Yoriaki
Nara Medical University Department Of Urology
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Wakabayashi Keiji
Department Of Food & Nutritional Science Graduate School Of Nutrition & Environmental Scienc
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Konishi Yoichi
Oklahoma Medical Research Foundation
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Okuyama Toru
Meiji Pharmaceutical Univ. Tokyo Jpn
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Kaneko Y
Department Of Urology Nara Prefectural Mimuro Hospital
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Muramatsu Takashi
Department Of Pathology Tokyo Dental College
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Suzuki Takashi
Laboratory Of Brain Research Oral Health Science Center Tokyo Dental College
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DENDA Ayumi
Department of Molecular Pathology, Nara Medical University
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