膀胱腫瘍に関する実験的研究 : 第1報 N-Butyl-N-Butanol (4)-Nitrosamine 投与によるダイコクネズミの膀胱腫瘍発生について

概要

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In the present study, the urinary bladder tumors in male rats of Wistar strain were induced by oral administration of N-Butyl-N-Butanol (4)-Nitrosamine (BBN). The results were as follow: 1) An incidence of urinary bladder and renal pelvic tumors were observed in rats by 0.05 % BBN administration; All (100 %) of the ten rats had tumors of urinary bladder, and two (200 %)of the ten rats combined renal pelvic tumor. 2) BBN showed an organotropic effect on the epithelium of urinary tract, especially urinary bladder, with high indicence and short induction time. 3) Histologically and histochemically, there were transitional cell type tumors, resembling human bladder tumors. 4) The tumors of urinary bladder were classified as four grades according to the histological malignancy and the invading of tumor cells. 5) The results were discussed relating to human urinary bladder tumor, and the experimental studies of BBN induced tumor could be useful for the application to the clinical studies of the human urinary bladder tumor.
社団法人日本泌尿器科学会の論文