Promoting Effect of Sodium L-Ascorbate on N-Butyl-N-(4-hydroxybutyl)nitrosamine-induced Renal Pelvic Carcinogenesis in SD/cShi Rats of Both Sexes

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概要

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• Susceptibility to the promoting effects of sodium L-ascorbate (Na-AsA) on the development of pelvis and urinary bladder tumors in male and female SD/cShi rats, featuring spontaneous hydronephrosis, was investigated. Rats received 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in their drinking water for 4 weeks and subsequently given basal diet with or without a 5% Na-AsA supplement for 32 weeks. Histopathological examination revealed the promoting effect of Na-AsA on not only the development of urinary bladder tumors but also renal pelvic tumors in the animals of both sexes in this two-stage carcinogenesis experiment, the effect being more prominent in males. Administration of either BBN or Na-AsA alone also induced papillomas and papillary or nodular hyperplasia of renal pelvis or urinary bladder, respectively, in male but not female rats. However, the 5-bromo-2-deoxyuridine-labeling index of urothelium in the pelvis and bladder increased slightly in male rats and significantly in female rats given Na-AsA alone for 8 weeks. N-butyl-N-(3-carboxypropyl)nitrosamine, which is a metabolite of BBN and proximate carcinogen, was found more in the urine of urinary bladder than that of renal pelvis. These results indicate that the urothelium of the renal pelvis and urinary bladder in SD/cShi rats is susceptible to promoting effects of Na-AsA in the present two stage model urinary tract carcinogenesis, with the urinary bladder of male rats as the most sensitive organ.

• 日本毒性病理学会の論文
• 2003-12-30

著者

• MORI Yukio

  Institute of Biological Pharmacy, Gifu Pharmaceutical University

• KOIDE Akihiro

  Institute of Biological Pharmacy, Gifu Pharmaceutical University

• FUKUSHIMA Shoji

  First Department of Pathology, Osaka City University Medical School

• Fukushima S

  Japan Bioassay Research Center Japan Industrial Safety And Health Association

• KOIDE Akihiro

  Gifu Pharmaceutical University

• MORI Yukio

  Gifu Pharmaceutical University

• Wanibuchi Hideki

  大阪府立成人病センター 分子生物学

• Wanibuchi Hideki

  First Department Of Pathology Osaka City University Medical School

• Mori Yukio

  Institute Of Biological Pharmacy Gifu Pharmaceutical University

• Morishita Y

  First Department Of Pathology Gifu University School Of Medicine

• Miyauchi Hideyuki

  Developmental Research Laboratories Shionogi & Co. Ltd.

• MAKINO Susumu

  Aburahi Laboratories Shionogi Research Laboratories

• MURAI Takashi

  First Department of Pathology, Osaka City University Medical School

• KOIDE Akihiro

  Laboratory of Radiochemistry, Gifu Pharmaceutical University

• INOUE Satoshi

  Developmental Research Laboratories, Shionogi & Co., Ltd.

• MARUYAMA Toshiyuki

  Developmental Research Laboratories, Shionogi & Co., Ltd.

• MORI Satoru

  First Department of Pathology, Osaka City University Medical School

• MORI Yukio

  Laboratory of Radiochemistry, Gifu Pharmaceutical University

• Mori Satoru

  大阪市立大学 医学部病理学第1

• Mori Satoru

  Department Pathology Osaka City University Medical School

• Makino Susumu

  Aburahi Laboratories Shionogi Research Laboratories Shionogi & Co. Ltd.

• Makino Susumu

  大阪市立大学 医学部病理学第1

• Makino Susumu

  Aburahi Laboratories Shionogi & Co. Ltd.

• Murai Takashi

  Department Pathology Osaka City University Medical School

• Fujiwara Yushi

  Department Of Surgery Osaka City Juso Hospital

• Koide Akihiro

  Institute Of Biological Pharmacy Gifu Pharmaceutical University

• Mori Yukio

  Laboratory Of Radiochemistry Gifu Pharmaceutical University

• Wanibuchi H

  Department Of Pathology Osaka City University Medical School

• Fujiwara Yushi

  Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine

• Yoshimoto Masatoshi

  Department Of Oncological Pathology Cancer Center Nara Medical University

• Fukushima Shoji

  First Department Of Pathology Nagoya City University Medical School

• Fukushima Shoji

  Dept. Pathol. Osaka City University Medical School

• Maruyama Toshiyuki

  Developmental Labs. Shionogi & Co. Ltd

• Fukushima Shoji

  Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.

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