Atrophy of Rat Exorbital Lacrimal Glands Induced by Atropine
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概要
- 論文の詳細を見る
To assess the morphological changes of the lacrimal gland after cholinergic suppression, we performed light- and transmission-electron microscopic examinations on the exorbital lacrimal glands in rats after intragastric intubation of atropine, a nonselective antimuscarinic compound with a high affinity for M3 muscarinic subtype receptors. In addition, areas of acinar cells were measured by an image processor. The weights of the lacrimal gland were decreased at hours 36 and 48 after atropine single administration at 250 mg/kg. Areas of acinar cells, measured by an image processor, were also decreased. Electron-microscopic examination demonstrated decreased number of secretory granules in the apical cytoplasm of acinar cells in all rats on days 7 and 28 of repeated atropine treatment. No changes were evident in other cytoplasmic organelles. Four- and even thirteen-week repeated administration studies revealed no progression in lacrimal acinar cell atrophy. The present findings demonstrate that an antimuscarinic compound that has high affinity for M3 muscarinic subtype receptors induces lacrimal gland acinar cell atrophy caused by a decrease in secretory granules, and that the repeated administration is not associated with any progression or any other changes.
- 日本毒性病理学会の論文
- 1999-09-01
著者
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TAGAWA Yoshiaki
Safety Assessment Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd.
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FUKUSHIMA Shoji
First Department of Pathology, Osaka City University Medical School
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KUMAZAWA Toshihiko
Safety Assessment Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd.
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Tagawa Yoshiaki
Safety Assessment Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.
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Tagawa Yoshiaki
Safety Assessment Group Central Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.
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Kumazawa Toshihiko
Safety Assessment Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.
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Kumazawa Toshihiko
Safety Assessment Group Central Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.
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IWAI Hisakazu
Safety Assessment Group, Central Research Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd.
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HARUYAMA Kiyoshi
Safety Assessment Group, Central Research Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd.
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ICHIKAWA Kazuhito
Safety Assessment Group, Central Research Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd.
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Iwai Hisakazu
Safety Assessment Group Central Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.
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Ichikawa Kazuhito
Safety Assessment Group Central Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.
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Fukushima Shoji
First Department Of Pathology Nagoya City University Medical School
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Fukushima Shoji
First Department Of Pathology Osaka City University Medical School
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Haruyama Kiyoshi
Safety Assessment Group Central Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.
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