Lack of Influence of Testicular Castration or Sialoadenectomy on Sodium L-Ascorbate Promotion of Urinary Bladder Carcinogenesis in Male F344 Rats
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概要
- 論文の詳細を見る
The study was designed to investigate whether testicular castration (TC) or sialoadenectomy (SE) can influence sodium L-ascorbate (Na-AsA)-promoting effects on urinary bladder carcinogenesis in male F344/DuCrj rats. The animals, 6 weeks old at the commencement of the treatment, were given 0.05% N-butyl-N- (4-hydroxybutyl)nitrosamine (BBN) in their drinking water for 4 weeks and then subjected to TC or SE. Thereafter they received basal diet with or without 5% Na-AsA supplement for 32 weeks. Na-AsA caused significant increase in urinary pH, the concentrations of sodium ion, and total ascorbic acid, whereas these urinary parameters were not influenced by TC and SE. TC significantly decreased the relative organ weights of the accessory sexual glands, kidneys, and livers whereas SE was without effect on these organs. TC and SE decreased very slightly BBN-induced carcinogenesis, but TC and SE did not influence the Na-AsA-promoting effects. The present results indicate that Na-AsA-promotion of two-stage urinary bladder carcinogenesis does not depend on the presence of testes or salivary glands.
- 日本毒性病理学会の論文
- 2003-09-30
著者
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MORIMURA Keiichirou
Department of Pathology, Osaka City University Medical School
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FUKUSHIMA Shoji
First Department of Pathology, Osaka City University Medical School
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Wanibuchi Hideki
大阪府立成人病センター 分子生物学
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Wanibuchi Hideki
First Department Of Pathology Osaka City University Medical School
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Morimura K
Department Of Pathology Osaka City University Medical School
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Morimura Keiichirou
大阪市立大学 医学部都市医学
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Morimura Keiichirou
First Department of Pathology Osaka City University Medical School
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MURAI Takashi
First Department of Pathology, Osaka City University Medical School
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MORI Satoru
First Department of Pathology, Osaka City University Medical School
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Mori Satoru
大阪市立大学 医学部病理学第1
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Mori Satoru
Department Pathology Osaka City University Medical School
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Makino Susumu
Aburahi Laboratories Shionogi Research Laboratories Shionogi & Co. Ltd.
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Makino Susumu
大阪市立大学 医学部病理学第1
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Murai Takashi
Department Pathology Osaka City University Medical School
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Fujiwara Yushi
Department Of Surgery Osaka City Juso Hospital
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Wanibuchi H
Department Of Pathology Osaka City University Medical School
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Fukushima Shoji
中央労働災害防止協会日本バイオアッセイ研究センター
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Fukushima Shoji
First Department Of Pathology Nagoya City University Medical School
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Fukushima Shoji
Dept. Pathol. Osaka City University Medical School
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Fukuhara Kennichirou
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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