Influence of Strain and Diet on Hepatocarcinogenicity of N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in Rats : Slight Inhibition of Preneoplastic Liver Lesion Development by Uracil
スポンサーリンク
概要
- 論文の詳細を見る
To assess sensitivity to hepatocarcinogenesis by BBN, formalin-fixed and paraffin-embedded rat liver tissues from two initiation/promotion (I/P) bioassays for urinary bladder carcinogenesis were sectioned, immunohistochemically stained for glutathione S-transferase placental form (GST-P), and quantitatively analyzed. In Experiment 1, male Sprague-Dawley (SD)/cShi strain rats (highly sensitive to urinary bladder carcinogenesis by BBN) and SD/gShi rats (insensitive), were treated with 0.05% BBN in the drinking water for 4 weeks and then housed for up to week 36, with or without exposure to bladder tumor promoters. Slightly higher quantitative values for small GST-P positive (GST-P+) foci were found in SD/gShi rats (8.57/cm2) compared to SD/cShi rats (2.48/cm2). In Experiment 2, F344 and Lewis rats, subjected to a similar I/P protocol, were maintained on MF or CA-1 diet for 36 weeks. Higher quantitative values of GST-P + hepatocytic foci (more than 0.1 mm in diameter) were found in Lewis rats (9.51/cm2 for MF diet; 7.95/cm 2 for CA-1 diet) compared to F344 rats (2.82/cm2 and 1.30/cm2, respectively). Slight inhibiting effects of GST-P+ foci were apparent in rats receiving uracil, but not sodium L-ascorbate, in the present experiment. Thus, it was confirmed that the bladder carcinogen BBN also targets the liver. The results, from quantitative analysis of small GST-P+ foci as end-point marker lesions, indicate considerable strain differences, but that liver tumor modifying potential of test chemicals can be evaluated in I/P protocols for urinary bladder carcinogenesis using any strain of rat.
- 日本毒性病理学会の論文
- 2005-06-30
著者
-
HAGIWARA Akihiro
DIMS Institute of Medical Science, Inc.
-
Doi Yuko
DIMS Institute of Medical Science, Inc.
-
FUKUSHIMA Shoji
First Department of Pathology, Osaka City University Medical School
-
Hagiwara A
Dims Institute Of Medical Science Inc.
-
Hagiwara Akihiro
Dims医科学研究所
-
Hagiwara Akihiro
大阪市立大学 医学部病理学第1
-
Hagiwara Akihiro
Dims Inst. Medical Sci. Inc.
-
NABAE Kyoko
DIMS Institute of Medical Science, Inc.
-
ICHIHARA Toshio
DIMS Institute of Medical Science, Inc.
-
YOSHINO Hiroko
DIMS Institute of Medical Science, Inc.
-
HIGA Yoshitaka
Sansho Seiyaku Co., Ltd.
-
Ichihara Toshio
Dims医科学研究所
-
Ichihara Toshio
Dims Institute Of Medical Science Inc.
-
Ichihara Toshio
Department Of Pathology Osaka City University Medical School
-
Ichihara Toshio
大阪市立大学 病理
-
Yoshino Hiroko
名古屋市立大学 医学研究科実験病態病理学分野
-
Yoshino Hiroko
Dims Institute Of Medical Science Inc.
-
Fukushima S
Japan Bioassay Research Center Japan Industrial Safety And Health Association
-
MURAI Takashi
First Department of Pathology, Osaka City University Medical School
-
MORI Satoru
First Department of Pathology, Osaka City University Medical School
-
Mori Satoru
大阪市立大学 医学部病理学第1
-
Mori Satoru
Department Pathology Osaka City University Medical School
-
Makino Susumu
Aburahi Laboratories Shionogi Research Laboratories Shionogi & Co. Ltd.
-
Makino Susumu
大阪市立大学 医学部病理学第1
-
Doi Yuko
Dims Institute Of Medical Science Inc.
-
Murai Takashi
Department Pathology Osaka City University Medical School
-
Fujiwara Yushi
Department Of Surgery Osaka City Juso Hospital
-
Higa Yoshitaka
Sansho Seiyaku Co. Ltd.
-
MIYATA Emiko
DIMS Institute of Medical Science, Inc.
-
Miyata Emiko
Dims Institute Of Medical Science Inc.
-
Ichihara Toshio
Department Of Physics Graduate School Of Science Osaka University
-
Ichihara Toshio
Dims Institute Of Medical Science
-
Fujiwara Yushi
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
-
Nabae Kyoko
Dims Institute Of Medical Science Inc.
-
Fukushima Shoji
中央労働災害防止協会日本バイオアッセイ研究センター
-
Fukushima Shoji
Japan Bioassay Research Center
-
Fukushima Shoji
First Department Of Pathology Nagoya City University Medical School
-
Fukushima Shoji
Dept. Pathol. Osaka City University Medical School
-
Hagihara Atsushi
Department Of Pathology Osaka City University Medical School
-
Fukuhara Kennichirou
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
-
Hagiwara Akihiro
First Department Of Pathology Nagoya City University Medical School
-
Fukushima Shoji
Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.
関連論文
- Ninety-day oral toxicity study of rhamsan gum, a natural food thickener produced from Sphingomonas ATCC 31961, in Crl:CD(SD)IGS rats
- A twenty eight-day repeated dose toxicity study of black soybean extract in Sprague-Dawley rats
- N-Methyl-N-nitrosourea Concentration-dependent, Rather than Total Intake-dependent, Induction of Adenocarcinomas in the Glandular Stomach of BALB/c Mice
- LACK OF HINOKITIOL (BETA-THUJAPLICIN) CARCINOGENICITY IN F344/DuCrj RATS
- Close Relation of Transforming Growth Factor-α Positive Hepatic Foci to Hepatocellular Tumor Development in the Rat
- Lack of Effects of Gestational and Lactational Exposure to 4-Nonylphenol on PhIP-Induced Rat Prostate Carcinogenesis
- Thirteen-Week Oral Toxicity Study of Dokudami Extract (Houttuynia Cordata Thunb.) in F344/DuCrj Rats
- Dose Dependent Promoting Effects of Hexachlorobenzene on Hepatocarcinogenesis in a Rat Medium-Term Liver Bioassay(Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Lack of Chemoprevention or Promotion Effects of Docosahexaenoic Acid on Small Intestine, Colon, Liver, Lung, Thyroid, Esophagus, Kidney, and Forestomach Carcinogenesis in a Rat Medium-Term Multi-Organ Carcinogenesis Model
- Evidence of a Threshold Dose for Promotion of Hepatocarcinogenesis by Hexachlorobenzene in a Rat Medium-Term Liver Bioassay
- P6-42 Mouse medium-term skin carcinogenesis bioassay of kojic acid(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- FOUR-WEEK ORAL TOXICITY STUDY OF 1-CARBOXY-5,7-DIBROMO-6-HYDROXY-2,3,4-TRICHLOROXANTHONE (HXCA), AN IMPURITY OF PHLOXINE B, IN F344 RATS
- Dose-related changes in gene expression in the livers of rats treated with sodium Phenobarbital as assessed using a three-dimensional microarray system. (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30t
- Ninety-toxicity study of annatto extract, a natural food color, in rats. (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- LACK OF CARCINOGENIC RISK IN THE PROSTATE WITH TRANSPLACENTAL AND LACTATIONAL EXPOSURE TO BISPHENOL A IN RATS
- A 28-day oral toxicity study of fermentation-derived cellulose, produced by Acetobacter aceti subspecies xylinum, in F344 rats
- Reliability Evaluation of the Mediumterm Liver Bioassay Based on Long-term Feeding Study Results for Phenobarbital with Reference to the Dose-response
- Significance of Cyclin D1 Overexpression in Transitional Cell Carcinomas of the Urinary Bladder and its Correlation with Histopathological Features
- Ninety-day oral toxicity study of rhamsan gum, a natural food thickener produced from Sphingomonas ATCC 31961, in Crl:CD(SD)IGS rats
- Differences in Sensitivity of F344 Rats from Different Breeders to Phenobarbital Hepatocarcinogenicity
- Differences in susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis between SD/gShi rats with spontaneous hypospermatogenesis and SD/cShi rats with spontaneous hydronephrosis
- Promoting Effect of Sodium L-Ascorbate on N-Butyl-N-(4-hydroxybutyl)nitrosamine-induced Renal Pelvic Carcinogenesis in SD/cShi Rats of Both Sexes
- Atrophy of Rat Exorbital Lacrimal Glands Induced by Atropine
- Use of Partially Nephrectomized Rats for Toxicity Studies : Comparison of Partially Nephrectomized Rats and Normal Rats
- Chemopreventive Effects of Coumaperine from Pepper on the Initiation Stage of Chemical Hepatocarcinogenesis in the Rat
- Promotion of Rat Hepatocarcinogenesis by Dimethylarsinic Acid : Association with Elevated Ornithine Decarboxylase Activity and Formation of 8-Hydroxydeoxyguanosine in the Liver
- CARCINOGENICITY OF DIFOLATAN IN B6C3F_1 MICE
- A DOSE-RELATED INDUCTION OF γ-GT POSITIVE FOCI BY N-NITROSODIMETHYLAMINE IN RAT LIVER IN AN IN VIVO SHORT TERM SYSTEM
- EFFECTS OF PARTIAL HEPATECTOMY AND CARBON TETRACHLORIDE ON THE INDUCTION OF HYPERPLASTIC NODULES IN THE LIVER TREATED WITH N-2-FLUORENYLACETAMIDE
- SACCHARIN-INDUCED HYPERPLASIA OF THE RAT URINARY BLADDER
- EFFECTS OF THE CO-MUTAGEN N0RHARMAN IN RATS (The 6th Meeting for the Study of Toxic Effect)
- HISTOPATHOLOGICAL STUDY OF SUBACUTE EFFECTS OF CARBAZOLE IN MICE (The 6th Meeting for the Study of Toxic Effect)
- SUBACUTE TOXICITY STUDY OF N, N'-DIPHENYL-P-PHENYENEDIAMINE IN RATS (The 6th Meeting for the Study of Toxic Effect)
- Inhibitory Effects of S-Methylcysteine and Cysteine on the Promoting Potential of Sodium Phenobarbital on Rat Liver Carcinogenesis
- Molecular cytogenetic identification of cyclin D1 gene amplification in a renal pelvic tumor attributed to phenacetin abuse
- Urinary Bladder Lesions after the Chernobyl Accident : Immunohistochemical Assessment of p53, Proliferating Cell Nuclear Antigen, Cyclin D1 and p21^
- Promotion by Sodium L-Ascorbate in Rat Two-stage Urinary Bladder Carcinogenesis is Dependent on the Interval of Administration
- Cyclin D1 Overexpression in Rat Two-Stage Bladder Carcinogenesis and its Relationship with Oncogenes, Tumor Suppressor Genesand Cell Proliferation
- Inhibition of Development of N,N'-Dimethylhydrazine-induced Rat Colonic Aberrant Crypt Foci by Pre, Post and Simultaneous Treatments with 24R ,25-Dihydroxyvitamin D_3
- PREVENTION BY NATURAL FOOD ANTHOCYANINS, PURPLE SWEET POTATO COLOR AND RED CABBAGE COLOR, OF 2-AMINO- 1 -METHYL-6-PHENYLIMIDAZO [4,5 -b] PYRIDINE (PhIP)-ASSOCIATED COLORECTAL CARCINOGENESIS IN RATS INITIATED WITH 1,2-DIMETHYLHYDRAZINE
- Susceptibility of Four F_1 Hybrids of Male Rats to the Promoting Effects of Sodium L-ascorbate in Two-Stage Urinary Bladder Carcinogenesis
- Dose-dependent Induction of Mammary Carcinomas in Female Sprague-Dawley Rats with 2-Amino-1-methyl-6-phenylimidazo [4,5-b] pyridine
- B-26 ORGAN SPECIFIC EFFECT OF TUMOR DEVELOPMENT BY LOW DOSE COMBINATIONS OF MODIFICATION AGENTS IN WIDE-SPECTRUM CARCINOGENESIS MODEL USING F344 RATS
- IMMUNOHISTOCHEMICAL IDENTIFICATION OF KERATIN, INVOLUCRIN, AND EPITHELIAL MEMBRANE ANTIGEN IN PAGET'S DISEASE.
- HISTOCHEMICAL OBSERVATION OF LECTIN-BINDING PATTERNS IN PAGET'S DISEASE
- Modification by Analgesics of Lesion Development in the Urinary Tract and Various Other Organs of Rats Pretreated with Dihydroxy-di-N-propylnitrosamine and Uracil
- 325 Synergistic Enhancement of Glutathione S-Transferase Placental Form-positive Hepatic Foci Development in Diethylnitrosamine-treated Rats by Combined Administration of Five Heterocyclic Amines at Low Doses
- A07 LACK OF MODIFYING EFFECTS OF 2 OXIDATIVE TYPE HAIR DYES ON INDUCTION OF PRENEOPLASTIC GLUTATHIONE S-TRANSFERASE PLACENTAL FORM POSITIVE FOCI IN A MEDIUM-TERM BIOASSAY SYSTEM USING F344 RATS
- LACK OF MODIFYING EFFECTS OF 2, 2'-[(4-AMINOPHENYL) IMINO] BISETHANOL SULFATE ON INDUCTION OF PRENEOPLASTIC γ-GLUTAMYL TRANSPEPTIDASE-POSITIVE FOCI IN A MEDIUMTERM BIOASSAY SYSTEM USING F344 RATS
- SPONTANEOUS TUMORS IN B6C3F_1 MICE
- ASSAY OF 7 COMPOUNDS FOR PROMOTING POTENTIAL ON THE DEVELOPNENT OF γ-GLUTAMIL TRANSPEPTIDASE-POSITIVE LIVER CELL FOCI IN THE RAT
- MORPHOLOGICAL STUDY OF STRAIN DIFFERENCES FOR THE EFFECTS OF SODIUM SACCHARIN ON THE URINARY BLADDER IN RATS
- LACK OF INHIBITORY EFFECTS OF THE JU-MYO PROTEIN ON DEVELOPMENT OF GLUTATHIONE S-TRANSFERASE PLACENTAL FORM-POSITIVE FOCI IN THE MALE F344 RAT LIVER
- Possible tumor development from double positive foci for TGF-alpha and GST-P observed in early stages on rat hepatocarcinogenesis
- CHRONIC TOXICITY STUDIES WITH N,N'-DIPHENYL-P-PHENYLENEDIAMINE IN RATS
- Influence of Strain and Diet on Hepatocarcinogenicity of N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in Rats : Slight Inhibition of Preneoplastic Liver Lesion Development by Uracil
- Promotion of Skin Carcinogenesis by Dimethylarsinic Acid in Keratin (K6)/ODC Transgenic Mice
- SUBCHRONIC ORAL TOXICITY STUDY WITH MORPHOLINE OLEIC ACID SALT IN B6C3F_1 MICE
- THIRTEEN WEEKS SUBACUTE ORAL TOXICITY STUDY WITH SODIUM ORTHO-PHENYL-PHENATE (OPP-Na) IN B6C3F_1 MICE
- Carcinogenicity of Methylurea or Morpholine in Combination with Sodium Nitrite in a Rat Multi-organ Carcinogenesis Bioassay
- Lack of Promoting Effects of α-Linolenic, Linoleic or Palmitic Acid on Urinary Bladder Carcinogenesis in Rats
- KOJIC ACID-ABSENCE OF TUMOR-INITIATING ACTIVITY IN RAT LIVER, AND OF CARCINOGENIC AND PHOTO-GENOTOXIC POTENTIAL IN MOUSE SKIN
- Annatto extract, a carotenoid natural food color, lacks tumor promoting effects in a medium-term liver carcinogenesis bioassay in rats (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- 90-day repeated dose toxicity study of gum arabic(General toxicity, Proceedings of the 32nd Annual Meeting)
- LACK OF SIGNIFICANT ALTERATION IN THE PROSTATE OR TESTIS OF F344 RAT OFFSPRING AFTER TRANSPLACENTAL AND LACTATIONAL EXPOSURE TO BISPHENOL A
- Effect of bisphenol A, an endocrine disruptor, on hepatocarcinogenesis and on reproductive system in medium-term liver bioassay.(GENERAL SESSION BY POSTER PRESENTATION)(ACTIVE OXYGEN ETC)
- RELIABILITY AND PRACTICALITY OF MEDIUM-TERM CARCINOGENESIS BIOASSAYS(WORKSHOP 4 : NEW TECHNOLOGY AND EVALUATIONS OF IN VIVO TOXICITY STUDIES)
- DOSE-RELATED INCREASES IN QUANTITATIVE VALUES FOR GLUTATHIONE S-TRANSFERASE PLACENTAL FORM (GST-P) POSITIVE FOCI AND CYTOCHROME P-450 LEVELS IN THE LIVER OF F344 RATS EXPOSED TO PHENOBARBITAL SODIUM (PB) IN A MEDIUM-TERM BIOASSAY
- Lack of Influence of Testicular Castration or Sialoadenectomy on Sodium L-Ascorbate Promotion of Urinary Bladder Carcinogenesis in Male F344 Rats
- Site-specific Effects of Testosterone Propionate on the Prostate of Rat Pretreated with 3,2'-Dimethyl-4-aminobiphenyl : Dose-dependent Induction of Invasive Carcinomas
- Strain Differences in Sensitivity to the Promoting Effect of Sodium L-Ascorbate in a Two-stage Rat Urinary Bladder Carcinogenesis Model
- Organ-dependent Modifying Effects of Caffeine, and Two Naturally Occurring Antioxidants α-Tocopherol and n-Tritriacontane-16, 18-dione, on 2-Amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) -induced Mammary and Colonic Carcinogenesis in Female F344
- "P-33 Inhibition of development of naturally occuring GST-P positive hepatocytic foci in rats chronically treated with phenolic compounds
- DOSE-DEPENDENT INDUCTION OF CARCINOMAS AND GLUTATHIONE S-TRANSFERASE PLACENTAL FORM NEGATIVE EOSINOPHILIC FOCI IN THE RAT LIVER BY DI(2-ETHYLHEXYL)PHTHALATE AFTER DIETHYLNITROSAMINE INITIATION
- MEDIUM-TERM BIOASSAYS AS ALTERNATIVE CARCINOGENICITY TEST
- EFFECTS OF A MIXTURE OF ADI DOSES OF 20 PESTICIDES ON RAT HEPATOCARCINOGENESIS
- INHIBITING EFFECTS OF DIETHYLMALEATE OR NH_4Cl ON NaHCO_3, BUT NOT BUTYLATED HYDROXYANISOLE, PROMOTION OF URINARY BLADDER CARCINOGENESIS IN MALE F344 RATS INITIATED WITH N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE
- Overexpression of Cyclin D1 in Rat Esophageal Carcinogenesis Model
- 21C-10-5 Effect of Hepatocarcinogenesis of Tamoxifen in the Medium-term Liver Bioassay (Ito Model).
- 3A-07 Muiti-Organ Carcinogenesis Bioassay of Quinoid Madder Colors
- ENHANCEMENT OF INTESTINAL TUMOR INDUCTION BY LOW DOSE COMBINATIONS OF HETEROCYCLIC AMINES IN A MULTI-ORGAN CARCINOGENESIS BIOASSAY
- RISK ASSESSMENT OF MIXTURES OF 40 OR 20 PESTICIDES AT ADI DOSES IN A MEDIUM-TERM MULTI-ORGAN CARCINOGENESIS BIOASSAY USING F344 MALE RATS
- LACK OF INHIBITORY EFFECTS OF THE JU-MYO PROTEIN ON DEVELOPMENT OF GLUTATHIONE S-TRANSFERASE PLACENTAL FORM-POSITIVE FOCI IN THE MALE F344 RAT LIVER
- DIFFERENT RESPONSE OF PHENOBARBITAL PROMOTION ON THE DEVELOPMENT OF γ-GLUTAMYLTRANSPEPTIDASE-POSITIVE FOCI (γ-GT) IN THE RAT LIVER INITIATED WITH DIETHYLNITROSAMINE (DEN), N-HYDROXY-2-ACETYLAMINOFLUORENE (N-OH-AAF) AND AFLATOXIN B_1 (Af-B_1)
- EFFECTS OF KOJIC ACID ON THYROIDAL FUNCTIONS IN RATS BY SINGLE-DOSE ADMINISTRATION AND IN CULTURED RAT THYROID CELLS (FRTL-5 CELLS)
- STUDIES ON THYROID FUNCTION IN RATS SUBJECTED TO REPEATED ORAL ADMINISTRATION WITH KOJIC ACID
- 21D-03-2 Action Mechanism of Kojic Acid on Rat Thyroid Function
- Effect of Kojic Acid on Rat Thyroid Gland Administered Orally for 4 Weeks
- Expression and Localization of Ornithine Decarboxylase in Reversible Papillomatosis Induced by Uracil in Rat Bladder
- S-Methylcysteine and Cysteine Are Inhibitors of Induction of Glutathione S-Transferase Placental Form-positive Foci during Initiation and Promotion Phases of Rat Hepatocarcinogenesis
- A11 MODIFYING EFFECTS OF BERAPROST SODIUM ON N-METHYL-N-NITROSOUREA CARCINOGENESIS IN F344 RATS
- 239 RATS WIDE-SPECTRUM INITATION MUTIPLE ORGAN BIOASSAY MODELS FOR ASSESSING MODIFYING EFFECTS IN NONHEPATOCARCINGENS
- Renal Pelvic Carcinoma Producing Granulocyte Colony-Stimulating Factor : Report of a Case
- Kojic acid biosynthesis in Aspergillus oryzae is regulated by a Zn(II)_2Cys_6 transcriptional activator and induced by kojic acid at the transcriptional level(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Sub-acute oral toxicity study with fullerene C60 in rats
- Concordance between Results of Medium-term Liver Carcinogenesis Bioassays and Long-term Findings for Carcinogenic 2-Nitropropane and Non-carcinogenic 1-Nitropropane in F344 Rats
- Concordance between Results of Medium-term Liver Carcinogenesis Bioassays and Long-term Findings for Carcinogenic 2-Nitropropane and Non-carcinogenic 1-Nitropropane in F344 Rats
- Lack of Tumor Promoting Effects of Carrageenan on 1,2-Dimethylhydrazine-induced Colorectal Carcinogenesis in Male F344 Rats
- Alpha2u-Globulin Nephropathy in Rats Treated with a Glycosaminoglycan Extracted from Sea Cucumber
- No Promoting Effect of Ethyl Tertiary-butyl Ether (ETBE)on Rat Urinary Bladder Carcinogenesis Initiated with N-Butyl-N-(4-hydroxybutyl)nitrosamine