Evidence of a Threshold Dose for Promotion of Hepatocarcinogenesis by Hexachlorobenzene in a Rat Medium-Term Liver Bioassay
スポンサーリンク
概要
- 論文の詳細を見る
The potential of hexachlorobenzene (HCB) to promote the development of glutathione S-transferase placental form (GST-P) positive foci in the male F344/DuCrj (F344) rat liver was evaluated with 11 different dietary doses, ranging from 0.002 to 75 ppm, using a medium-term liver bioassay system. No mortalities caused by HCB treatment were encountered, and no clinical changes were apparent. The numbers and areas of GST-P positive foci in the 0.002 ppm to 40 ppm groups were comparable with the control values, but those in the 75 ppm HCB group were slightly, albeit not significantly, increased. The present results indicate that HCB exerts weak promotion potential for rat liver carcinogenesis, but only at a dietary level of 75 ppm (5.27 mg/kg/day), thus providing evidence for the existence of a threshold.
- 日本毒性病理学会の論文
- 2005-03-30
著者
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HAGIWARA Akihiro
DIMS Institute of Medical Science, Inc.
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IMAI Norio
DIMS Institute of Medical Science, Inc.
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TAMANO Seiko
DIMS Institute of Medical Science, Inc.
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SHIRAI Tomoyuki
Department of Pathology, Nagoya City University Medical School
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Tamano S
Dims Institute Of Medical Science Inc.
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Tamano Seiko
Dims Inst. Medical Sci. Inc.
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Imai Norio
Dims Institute Of Medical Science Inc.
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Imai Norio
Dims医科学研究所
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Imai N
Department Of Experimental Pathology And Tumor Biology Nagoya City University Medical Sciences
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Hagiwara A
Dims Institute Of Medical Science Inc.
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Hagiwara Akihiro
Dims医科学研究所
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Hagiwara Akihiro
大阪市立大学 医学部病理学第1
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Hagiwara Akihiro
Dims Inst. Medical Sci. Inc.
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ICHIHARA Toshio
DIMS Institute of Medical Science, Inc.
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ICHIHARA Toshio
Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Me
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IMAI Norio
Department of Experimental Pathology and Tumor Biology, Nagoya City University Medical Sciences
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TODA Yosuke
DIMS Institute of Medical Science
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IMAI NORIO
Daiyu-kai Institute of Medical Science
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Shirai T
Experimental Pathology And Tumor Biology Graduate School Of Medical Sciences Nagoya City University
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Ichihara Toshio
Dims医科学研究所
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Ichihara Toshio
Dims Institute Of Medical Science Inc.
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Ichihara Toshio
Department Of Pathology Osaka City University Medical School
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Ichihara Toshio
大阪市立大学 病理
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Inaguma Shingo
大雄会医科学研究所
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Imai Norio
Department Of Biochemistry Faculty Of Science Nigata University
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Takesada Yasuko
Daiyu-kai Institute Of Medical Science Inc.
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Toda Yosuke
Dims Institute Of Medical Science Inc.
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SHIRAI Tomoyuki
Nagoya City University Medical School
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Ichihara Toshio
Department Of Physics Graduate School Of Science Osaka University
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Ito Nobuyuki
First Department Of Pathology Nagoya City University Medical School
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Shirai Tomoyuki
Department Of Biochemistry Niigata College Of Pharmacy
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Shirai T
大雄会医科学研究所
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Sugimura T
Carcinogenesis Division National Cancer Center Research Institute
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Hagihara Atsushi
Department Of Pathology Osaka City University Medical School
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Hagiwara Akihiro
First Department Of Pathology Nagoya City University Medical School
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Ito N
Nagoya City Univ. Nagoya
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ICHIHARA Toshio
Department of Earth and Space Science, Faculty of Science, Osaka University
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