Promoting Effects of Streptozotocin-induced Diabetes on Induction of Hepatic Preneoplastic Lesions by Diethylnitrosamine in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The effects of streptozotocin (STZ)-induced diabetes on induction of hepatic preneoplastic lesions by diethylnitrosamine (DEN) were investigated in male Fischer rats. A single dose of STZ was injected intravenously either 2 weeks before or after initiation with DEN. The blood glucose levels were significantly elevated from 1 week after STZ-injection until autopsy. The numbers of GST-P positive foci at 1 week after DEN administration in the STZ-injected rats were similar to those in the non-diabetic rats. In contrast, both the numbers and areas of GST-P positive foci > 2 mm in diameter 8 weeks after DEN administration were increased significantly in the rats treated with STZ after DEN exposure compared with the non-diabetic control rats. The results suggest that hepatic preneoplastic lesions initiated with DEN are promoted by STZ treatment-inducing diabetes.
- 日本毒性病理学会の論文
著者
-
SHIRAI Tomoyuki
Department of Pathology, Nagoya City University Medical School
-
ASAMOTO Makoto
Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Me
-
Tagawa Yoshiaki
Pharmaceutical Research Laboratories Sanwa Kagaku Kenkyusho Co. Ltd.
-
Shirai Tomoyuki
Department Of Biochemistry Niigata College Of Pharmacy
-
Asamoto Makoto
Department Of Experimental Pathology And Tumor Biology Graduate School Of Medical Sciences Nagoya Ci
-
Ichikawa Kazuhito
Drug Safety Management Department, Sanwa Kagaku Kenkyusho Co., Ltd.
-
Kawai Masaomi
Pharmaceutical Research Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd.
-
Kawai Masaomi
Pharmaceutical Research Laboratories Sanwa Kagaku Kenkyusho Co. Ltd.
-
Ichikawa Kazuhito
Drug Safety Management Department Sanwa Kagaku Kenkyusho Co. Ltd.
関連論文
- N,N-Bis(2-chloroethyl)- N-nitrosourea (BCNU)-induced Apoptosis of Neural Progenitor Cells in the Developing Fetal Rat Brain
- Lack of a Dose-response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-Nitrosodiethylamine
- LACK OF HINOKITIOL (BETA-THUJAPLICIN) CARCINOGENICITY IN F344/DuCrj RATS
- Close Relation of Transforming Growth Factor-α Positive Hepatic Foci to Hepatocellular Tumor Development in the Rat
- Lack of Effects of Gestational and Lactational Exposure to 4-Nonylphenol on PhIP-Induced Rat Prostate Carcinogenesis
- Thirteen-Week Oral Toxicity Study of Dokudami Extract (Houttuynia Cordata Thunb.) in F344/DuCrj Rats
- Dose Dependent Promoting Effects of Hexachlorobenzene on Hepatocarcinogenesis in a Rat Medium-Term Liver Bioassay(Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Lack of Chemoprevention or Promotion Effects of Docosahexaenoic Acid on Small Intestine, Colon, Liver, Lung, Thyroid, Esophagus, Kidney, and Forestomach Carcinogenesis in a Rat Medium-Term Multi-Organ Carcinogenesis Model
- Evidence of a Threshold Dose for Promotion of Hepatocarcinogenesis by Hexachlorobenzene in a Rat Medium-Term Liver Bioassay
- P6-42 Mouse medium-term skin carcinogenesis bioassay of kojic acid(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- A MEDIUM-TERM RAT LIVER BIOASSAY FOR RAPID IN VIVO DETECTION OF CARCINOGENIC POTENTIAL OF CHEMICALS
- Suppression of metastasis by nuclear factor кB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma
- Ninety-toxicity study of annatto extract, a natural food color, in rats. (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- LACK OF CARCINOGENIC RISK IN THE PROSTATE WITH TRANSPLACENTAL AND LACTATIONAL EXPOSURE TO BISPHENOL A IN RATS
- Effects of Antioxidant 1-O-Hexy1-2,3,5-trimethylhydroquinone or Ascorbic Acid on Carcinogenesis Induced by Administration of Aminopyrine and Sodium Nitrite in a Rat Multi-organ Carcinogenesis Model
- Suppression of Lung Metastasis by Aspirin but Not Indomethacin in an in vivo Model of Chemically Induced Hepatocellular Carcinoma
- Cyclooxygenase 2 and Prostaglandin E2 are not Involved in N-Nitrosodiethylamine-Initiated Early Rat Hepatocarcinogenesis
- Transforming growth factor β derived from bone matrix promotes cell proliferation of prostate cancer and osteoclast activation-associated osteolysis in the bone microenvironment
- Differences in Expression Patterns of Cell Cycle Regulators after Cessation of Genotoxic and Non-genotoxic Carcinogen Treatment in the Rat Forestomach
- Prediction of carcinogenic potential by a toxicogenomic approach using rat hepatoma cells
- Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist
- Limited Effects of Disrupted Gap Junctions in the Liver on Multi-organ Carcinogenesis Induced by Diisopropanolnitrosamine in the Mutant Connexin 32 Transgenic Rat
- Carcinogenic Effects of Mixtures of Chemicals
- Downregulation of apoptosis revealed by laser microdissection and cDNA microarray analysis of related genes in rat liver preneoplastic lesions
- Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo
- Clinicopathological analysis on cancers of autopsy cases in a geriatric hospital
- High susceptibility of the ACI and spontaneously hypertensive rat (SHR) strains to 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) prostate carcinogenesis
- Combined Chemopreventive Effects of Perilla or Corn Oil and Indomethacin in a Rat Medium-Term Multiorgan Carcinogenesis Model
- Collaborative work on evaluation of ovarian toxicity : 15) Two- or four-week repeated-dose studies and fertility study of bromocriptine in female rats
- Effects of Maternal Exposure to Nonylphenol on Growth and Development of the Female Reproductive System and Uterine Carcinogenesis in Rats
- Harman and Norharman Suppressed but NaNO_2 Enhanced the Development of Preneoplastic Liver Cell Foci in 2-Amino-3,8-Dimethylimidazo[4,5-f]Quinoxaline (MeIQx)-Treated Rats
- Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats
- A Transgenic Rat Model of Prostate Carcinogenesis
- Emergent biliary drainage for choledochal cyst
- LACK OF SIGNIFICANT ALTERATION IN THE PROSTATE OR TESTIS OF F344 RAT OFFSPRING AFTER TRANSPLACENTAL AND LACTATIONAL EXPOSURE TO BISPHENOL A
- Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats : Lack of influence of carcinogen or testosterone treatment
- A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals
- Repeated hepatocyte injury promotes hepatic tumorigenesis in hepatitis C virus transgenic mice
- Weak Bloch property for discrete magnetic Schrodinger operators
- Isoperimetric Constants of (d,f )-Regular Planar Graphs
- Toxicogenomics from the Viewpoint of Toxicologic Pathology(WORKSHOP 3 : TOXICOGENOMICS AND MOLECULAR TOXICOLOGY)
- Long time behavior of the transition probability of a random walk with drift on anabelian covering graph
- Promoting Effects of Streptozotocin-induced Diabetes on Induction of Hepatic Preneoplastic Lesions by Diethylnitrosamine in Rats
- Induction of apoptosis in the LNCaP human prostate carcinoma cell line and prostate adenocarcinomas of SV40T antigen transgenic rats by the Bowman-Birk inhibitor
- Momordica charantia leaf extract suppresses rat prostate cancer progression in vitro and in vivo
- Differences in Expression Patterns of Cell Cycle Regulators after Cessation of Genotoxic and Non-genotoxic Carcinogen Treatment in the Rat Forestomach
- Significance of chemoprevention for prostate cancer development : Experimental in vivo approaches to chemoprevention
- Periampullary somatostatinoma and multiple gastrointestinal stromal tumors associated with von Recklinghausen's disease
- Concordance between Results of Medium-term Liver Carcinogenesis Bioassays and Long-term Findings for Carcinogenic 2-Nitropropane and Non-carcinogenic 1-Nitropropane in F344 Rats
- N,N'-Bis(2-chloroethyl)-N-nitrosourea (BCNU)-induced Apoptosis of Neural Progenitor Cells in the Developing Fetal Rat Brain
- Promoting Effects of Streptozotocin-induced Diabetes on Induction of Hepatic Preneoplastic Lesions by Diethylnitrosamine in Rats
- Concordance between Results of Medium-term Liver Carcinogenesis Bioassays and Long-term Findings for Carcinogenic 2-Nitropropane and Non-carcinogenic 1-Nitropropane in F344 Rats
- Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens
- Cyclooxygenase 2 and Prostaglandin E2 are not Involved in N-Nitrosodiethylamine-Initiated Early Rat Hepatocarcinogenesis
- Establishment of an Invasive Prostate Cancer Model in Transgenic Rats by Intermittent Testosterone Administration
- Rapid analysis of gene expression changes caused by liver carcinogens and chemopreventive agents using a newly developed three-dimensional microarray system
- LACK OF COMBINATION HEPATOCARCINOGENICITY OF HARMAN, NORHARMAN AND AMITROLE WHEN GIVEN WITH NaNO_2 IN THE RAT
- Hypertension is positively associated with prostate cancer development in the TRAP transgenic rat model