A Transgenic Rat Model of Prostate Carcinogenesis

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概要

• 論文の詳細を見る

• We have generated a transgenic rat with the SV40 T antigen under probasin promoter control, allowing prostate specific gene expression. Males demonstrate atypical epithelial cell proliferation in the prostate from 4 weeks of age and develop prostate carcinomas at 100% incidence before they are 15 weeks old. These prostate caricnomas are completely androgen-dependent. Adequate materials of the prostate carcinomas, taking advantage of the rat transgenic model, allow us gene expression analysis for prostate carcinogenesis and involution process after castration. Male transgenic rats with a Sprague-Dawley genetic background were mated with wild-type females of F344, Wistar and ACI strains. F1 male transgenic hybrids with female Wistar and ACI rats had significantly lowered incidences of prostate carcinomas. However, the serum level of testosterone, and expression of the transgene, probasin, and the androgen receptor did not correlate with the strain variation in tumor development. These results clearly show that the transgenic rat is a good model for investigate prostate carcinogenesis and its modifying factors.

• 日本毒性病理学会の論文
• 2002-09-25

著者

• SHIRAI Tomoyuki

  Department of Pathology, Nagoya City University Medical School

• ASAMOTO Makoto

  Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Me

• Asamoto M

  Department Of Experimental Pathology And Tumor Biology Graduate School Of Medical Sciences Nagoya Ci

• Asamoto M

  Department Of Experimental Pathology And Tumor Biology Nagoya City University Graduate School Of Med

• Asamoto Makoto

  国立がんセンター

• Asamoto Makoto

  住友製薬大阪研究所

• HOKAIWADO Naomi

  Department of Experimental Pathology and Tumor Biology, Nagoya City University, Graduate School of M

• CHO Young-Man

  Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Me

• Cho Young-man

  名古屋市立大学 医研究病理1

• Cho Young-man

  Department Of Experimental Pathology And Tumor Biology Nagoya City University Graduate School Of Med

• Mutai Mamoru

  First Department Of Pathology Nagoya City University Medical School

• SHIRAI Tomoyuki

  Nagoya City University Medical School

• Hokaiwado Naomi

  Department Of Experimental Pathology And Tumor Biology Nagoya City University Graduate School Of Med

• Hokaiwado Naomi

  Experimental Pathology And Chemotherapy Division National Cancer Center Research Institute

• Shirai Tomoyuki

  Department Of Biochemistry Niigata College Of Pharmacy

• Asamoto Makoto

  Department Of Experimental Pathology And Tumor Biology Graduate School Of Medical Sciences Nagoya Ci

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