Carcinogenic Effects of Mixtures of Chemicals

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概要

• 論文の詳細を見る

• Our environment is a sea of chemicals composed of hundreds and thousands of chemicals with great diversity of pharmacological function and structure. Human populations are therefore generally exposed simultaneously to numbers of toxicants, including complex mixtures of chemicals of unknown and variable origin at low doses, some of which are carcinogens and some of which are non-carcinogens. Exposure may occur in different ways and interactions between multiple chemicals acting simultaneously or sequentially in humans are a very important issue for carcinogenic risk assessment and management. Experimental data demonstrate that at very low doses, summation or synergistic enhancement of carcinogenesis is unlikely, particularly in cases of non-genotoxic carcinogens. In this review, we would like to present published data on summation and/or synergistic effects of carcinogens, dependent on the dose applied.

• 日本毒性病理学会の論文
• 2006-03-01

著者

• TAKAHASHI Satoru

  Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Me

• 高橋 智

  首都大学東京 大学院理工学研究科機械工学専攻

• SHIRAI Tomoyuki

  Department of Pathology, Nagoya City University Medical School

• Tamano S

  Dims Institute Of Medical Science Inc.

• OGAWA Kumiko

  Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Me

• Shirai T

  Experimental Pathology And Tumor Biology Graduate School Of Medical Sciences Nagoya City University

• Shirai Tomoyuki

  ボゾリサーチセンター御殿場研究所

• Ogawa Kumiko

  名古屋市立大学 医学研究科実験病態病理学

• Ogawa K

  Nagoya City Univ. Medical School Nagoya

• Sugimura T

  Cancer Prevention Basic Research Project National Cancer Center Research Institute

• Takahashi Satoru

  Department Of Experimental Pathology And Tumor Biology Nagoya City University Graduate School Of Med

• Shimokawa T

  National Cancer Center Res. Inst. Tokyo Jpn

• SHIRAI Tomoyuki

  Nagoya City University Medical School

• Shirai Tomoyuki

  Graduate School Of Medical Sciences Nagoya City University

• Takahashi S

  Department Of Experimental Pathology And Tumor Biology Nagoya City University Graduate School Of Med

• Shirai Tomoyuki

  Department Of Biochemistry Niigata College Of Pharmacy

• Shirai T

  大雄会医科学研究所

• Tamano Seiko

  First Department Of Pathology Nagoya City University Medical School

• Sugimura T

  Carcinogenesis Division National Cancer Center Research Institute

• Shirai Tomoyuki

  Pathology Group Yakult Central Inst.

• Ogawa Kumiko

  Department Of Experimental Pathology And Tumor Biology Nagoya City University Graduate School Of Med

• Takahashi Satoru

  Department Of Anatomy And Embryology Biomolecular And Integrated Medical Sciences Graduate School Of

• Ogawa Kumiko

  Department Of Experimental Pathology And Tumor Biology Graduate School Of Medical Sciences Nagoya Ci

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