A twenty eight-day repeated dose toxicity study of black soybean extract in Sprague-Dawley rats

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概要

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• This study was designed to evaluate any adverse effect of a hot water extract of black soybeans (Glycine max (L.) Merr.), when administered to both sexes of Crj:CD(SD)IGS rats at dietary levels of 0 (control), 0.5, 1.5 and 5.0% (6 rats/sex/group). During the study, the treatment had no adverse effects on clinical signs, survival, body weights, and food and water consumption, or on findings of ophthalmology, urinalysis, hematology, or blood biochemistry. Organ weights, gross pathology and histopathology exhibited no differences of toxicological significance between control and treated rats. Thus, the no-observed-adverse-effect level (NOAEL) of black soybean extract was concluded to be 5.0% (3,618 mg/kg body weight/day for males and 4,066 mg/kg body weight/day for females) from the present study.

• 2010-02-01

著者

• HAGIWARA Akihiro

  DIMS Institute of Medical Science, Inc.

• IMAI Norio

  DIMS Institute of Medical Science, Inc.

• NUMANO Takamasa

  DIMS Institute of Medical Science, Inc.

• NAKASHIMA Hironao

  DIMS Institute of Medical Science, Inc.

• TAMANO Seiko

  DIMS Institute of Medical Science, Inc.

• SAKAUE Kazushi

  San-Ei Gen F.F.I., Inc.

• TANAKA Kiyofumi

  San-Ei Gen F.F.I., Inc.

• YASUHARA Kazuo

  San-Ei Gen F.F.I., Inc.

• HAYASHI Shim-mo

  San-Ei Gen F.F.I., Inc.

• 高橋 智

  首都大学東京 大学院理工学研究科機械工学専攻

• Yasuhara Kazuo

  San-ei Gen F.f.i. Inc.

• Yasuhara Kazuo

  大雄会医科学研究所

• Tamano S

  Dims Institute Of Medical Science Inc.

• Tamano Seiko

  Dims Inst. Medical Sci. Inc.

• Imai Norio

  Dims Institute Of Medical Science Inc.

• Imai Norio

  Dims医科学研究所

• Imai N

  Department Of Experimental Pathology And Tumor Biology Nagoya City University Medical Sciences

• Hagiwara A

  Dims Institute Of Medical Science Inc.

• Hagiwara Akihiro

  Dims医科学研究所

• Hagiwara Akihiro

  大阪市立大学 医学部病理学第1

• Hagiwara Akihiro

  Dims Inst. Medical Sci. Inc.

• Hayashi Shim-mo

  San-ei Gen F.f.i. Inc.

• IMAI NORIO

  Daiyu-kai Institute of Medical Science

• Shirai T

  Experimental Pathology And Tumor Biology Graduate School Of Medical Sciences Nagoya City University

• Shirai Tomoyuki

  ボゾリサーチセンター御殿場研究所

• Inaguma Shingo

  大雄会医科学研究所

• Sugimura T

  Cancer Prevention Basic Research Project National Cancer Center Research Institute

• Sugimura Takashi

  国立がんセンター研究所 生化学部

• Shimokawa T

  National Cancer Center Res. Inst. Tokyo Jpn

• SHIRAI Tomoyuki

  Nagoya City University Medical School

• Shirai Tomoyuki

  Graduate School Of Medical Sciences Nagoya City University

• Ito Nobuyuki

  First Department Of Pathology Nagoya City University Medical School

• Shirai T

  大雄会医科学研究所

• Tamano Seiko

  First Department Of Pathology Nagoya City University Medical School

• Sakaue Kazushi

  San-ei Gen F.f.i. Inc.

• Sugimura T

  Carcinogenesis Division National Cancer Center Research Institute

• Tanaka Kiyofumi

  San-ei Gen F.f.i. Inc.

• Numano Takamasa

  Dims Institute Of Medical Science Inc.

• Nakashima Hironao

  Dims Institute Of Medical Science Inc.

• Shirai Tomoyuki

  Pathology Group Yakult Central Inst.

• Shirai Tomoyuki

  Nagoya City Univ. Postgraduate School Of Medical Sci. Nagoya

• Hagihara Atsushi

  Department Of Pathology Osaka City University Medical School

• Hagiwara Akihiro

  First Department Of Pathology Nagoya City University Medical School

• Ito N

  Nagoya City Univ. Nagoya

• Tamano Seiko

  Daiyu-kai Institute Of Medical Science

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