LACK OF CARCINOGENIC RISK IN THE PROSTATE WITH TRANSPLACENTAL AND LACTATIONAL EXPOSURE TO BISPHENOL A IN RATS

スポンサーリンク

概要

• 論文の詳細を見る

• The current study was designed to examine the modulating effects of bisphenol A (BPA) on prostate cancer risk in male offspring exposed transplacentally and lactationally. BPA was administered to F344 female rats by gavage at 0, 0.05, 7.5, 30, 120 mg/kg/day during pregnancy and lactation periods. When F_1 males reached 5 weeks old, they were given 10 subcutaneous injections of 3,2'-dimethyl-4-aminobiphenyl (DMAB) or corn oil vehicle and rats were then sacrificed under ether anesthesia at week 60. There were no observable effects on the accessory sex organ weights of male offspring. Transplacental and lactational exposure to BPA did not affect the incidences of preneoplastic and neoplastic lesions in the accessory sex organs (prostate and seminal vesicle) of F_1 rats and did not induce any proliferating lesions without DMAB. Our data suggest that maternal exposure to BPA during the period of pregnancy and lactation does not affect the risk of prostate carcinogenesis in male offspring.

• 日本トキシコロジー学会の論文
• 2003-08-29

著者

• IMAI Norio

  DIMS Institute of Medical Science, Inc.

• 鈴木 修吾

  筑波大学物質工学系

• SHIRAI Tomoyuki

  Department of Pathology, Nagoya City University Medical School

• Tamano S

  Dims Institute Of Medical Science Inc.

• Imai Norio

  Dims Institute Of Medical Science Inc.

• Imai Norio

  Dims医科学研究所

• Imai N

  Department Of Experimental Pathology And Tumor Biology Nagoya City University Medical Sciences

• KAWABE Mayumi

  DIMS Institute of Medical Science, Inc.

• ICHIHARA Toshio

  DIMS Institute of Medical Science, Inc.

• SUZUKI Shugo

  Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Me

• KAWABE Mayumi

  Daiyu-Kai Institute of Medical Science, Inc.

• ICHIHARA Toshio

  Daiyu-Kai Institute of Medical Science, Inc.

• TAMANO Seiko

  Daiyu-Kai Institute of Medical Science, Inc.

• HIGA Yoshitaka

  Sansho Seiyaku Co., Ltd.

• YOSHINO Hiroko

  Daiyu-kai Institute of Medical Science

• IMAI NORIO

  Daiyu-kai Institute of Medical Science

• TSUTSUMI Tomoko

  Daiyu-Kai Institute of Medical Science

• INAGUMA Shingo

  Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Me

• Suzuki Shugo

  名古屋市立大学 医学研究科実験病態病理学分野

• Suzuki Shugo

  Department Of Experimental Pathology And Tumor Biology Nagoya City University Graduate School Of Med

• Kawabe Mayumi

  Dims Inst. Of Medical Sci. Inc.

• Kawabe Mayumi

  名古屋市立大学 医学研究科第一病理学

• Kawabe Mayumi

  Dims Inst. Medical Sci. Inc.

• Kawabe Mayumi

  三省製薬

• Ichihara Toshio

  Dims医科学研究所

• Ichihara Toshio

  Dims Institute Of Medical Science Inc.

• Ichihara Toshio

  Department Of Pathology Osaka City University Medical School

• Ichihara Toshio

  大阪市立大学 病理

• Tsutsumi Tomoko

  大雄会医科学研究所

• Yoshino Hiroko

  名古屋市立大学 医学研究科実験病態病理学分野

• Yoshino Hiroko

  Dims Institute Of Medical Science Inc.

• Inaguma S

  Nagoya City Univ. Graduate School Of Medical Sci. Nagoya

• Inaguma Shingo

  名古屋市立大学 医研究病理1

• Inaguma Shingo

  大雄会医科学研究所

• Inaguma Shingo

  Department Of Experimental Pathology And Tumor Biology Nagoya City University Graduate School Of Med

• Kuribayashi Masanori

  名古屋市立大学 医学研究科実験病態病理学分野

• Suzuki S

  Institute Of Materials Sciense Unibersity Of Tsukuba

• Higa Yoshitaka

  Sansho Seiyaku Co. Ltd.

• SHIRAI Tomoyuki

  Nagoya City University Medical School

• Tamano Seiko

  Daiyu-kai Institute Of Medical Science Ichinomiya Japan

• Ichihara Toshio

  Department Of Physics Graduate School Of Science Osaka University

• Ito Nobuyuki

  First Department Of Pathology Nagoya City University Medical School

• Shirai Tomoyuki

  Department Of Biochemistry Niigata College Of Pharmacy

• Shirai T

  大雄会医科学研究所

• Suzuki S

  Yokohama National Univ. Yokohama Jpn

• SUZUKI Soichiro

  Department of Applied Physics,Tokyo Institute of Technology

• Ito N

  Nagoya City Univ. Nagoya

• Tamano Seiko

  Daiyu-kai Institute Of Medical Science

• ICHIHARA Toshio

  Daiyu-kai Institute of Medical Science

関連論文

• 22pPSA-19 Fully Relativistic Full-Potential LCAO法によるウラン化合物の磁性に関する理論的研究III(22pPSA 領域3ポスターセッション(酸化物・f電子系磁性・スピングラス・量子スピン・フラストレーション系・実験技術・磁性一般),領域3(磁性,磁気共鳴))
• Ninety-day oral toxicity study of rhamsan gum, a natural food thickener produced from Sphingomonas ATCC 31961, in Crl:CD(SD)IGS rats
• A twenty eight-day repeated dose toxicity study of black soybean extract in Sprague-Dawley rats
• 25pPSA-64 Fully Relativistic Full-Potential LCAO法によるウラン化合物の磁性に関する理論的研究II(領域3ポスターセッション(スピントロニクス・遍歴磁性等),領域3,磁性,磁気共鳴)
• 27aPS-135 Fully Relativistic Full-Potential LCAO法によるウラン化合物の磁性に関する理論的研究I(27aPS 領域3ポスターセッション(遍歴磁性体・化合物磁性体・f電子系・磁性一般),領域3(磁性,磁気共鳴))
• 21pPSB-11 Fully Relativistic Full-Potential LCAO法によるウランモノカルコゲナイドのX線吸収磁気円二色性に関する理論的研究(21pPSB 領域3ポスターセッション,領域3(磁性,磁気共鳴))
• 18aPS-54 NiAs型構造MnX(X=As, Sb, Bi)の電子状態と磁気光学効果に関する理論的研究(18aPS 領域3ポスターセッション(磁性),領域3(磁性,磁気共鳴))
• First-principles calculations of the geometry and electronic structure of electron- and hole-doped C60 in the field-effect transistor structure
• ビスマス鉄ガーネットの相対論的バンド計算
• 22pXG-12 電場効果ドーピングされた分子性固体の構造と電子状態の第一原理からの研究 IV
• 21pXF-16 ホールドープ C_ の超伝導に関する理論的研究 II
• アルカリ金属ドープC_における軌道自由度の役割(2002年度基研研究会「軌道自由度を持つ強相関電子系の理論の進展」,研究会報告)
• 29pZB-13 ホールドープ C_ の超伝導に関する理論的研究
• 28pYD-7 電場効果ドーピングされた分子性固体の構造と電子状態の第一原理からの研究 III
• バンド計算によるガーネットの磁気光学効果
• ビスマス鉄ガーネットのバンド計算
• Theoretical Study on Anomalous Behaviors in Photoemission Spectra of Alkali-Metal-Doped C_
• Role of Orbital Degree of Freedom in Photoemission Spectra of Alkali-Metal-Doped C60 (Proceedings of the International Conference on Strongly Correlated Electrons with Orbital Degrees of Freedom(ORBITAL2001))
• 18pWF-2 A_4C_における励起子の理論的研究
• 18pWF-1 アクセプター型C_化合物の電子状態計算II
• 30pXD-5 アクセプター型C_化合物の電子状態計算
• 30pXD-4 A_3C_の有限温度における光電子スペクトルの理論的研究
• N,N-Bis(2-chloroethyl)- N-nitrosourea (BCNU)-induced Apoptosis of Neural Progenitor Cells in the Developing Fetal Rat Brain
• 6p-E-6 アクセプター型GIC(AsF-GIC、Br-GIC)の電子構造
• 31p-R-6 Br-GICの電子状態 : アクセプター型GICとなる電荷移動のメカニズム
• Lack of a Dose-response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-Nitrosodiethylamine
• 2a-YB-8 DNA塩基3量体の電子状態
• LACK OF HINOKITIOL (BETA-THUJAPLICIN) CARCINOGENICITY IN F344/DuCrj RATS
• Close Relation of Transforming Growth Factor-α Positive Hepatic Foci to Hepatocellular Tumor Development in the Rat
• Lack of Effects of Gestational and Lactational Exposure to 4-Nonylphenol on PhIP-Induced Rat Prostate Carcinogenesis
• Thirteen-Week Oral Toxicity Study of Dokudami Extract (Houttuynia Cordata Thunb.) in F344/DuCrj Rats
• Dose Dependent Promoting Effects of Hexachlorobenzene on Hepatocarcinogenesis in a Rat Medium-Term Liver Bioassay(Carcinogenicity, Proceedings of the 32nd Annual Meeting)
• Lack of Chemoprevention or Promotion Effects of Docosahexaenoic Acid on Small Intestine, Colon, Liver, Lung, Thyroid, Esophagus, Kidney, and Forestomach Carcinogenesis in a Rat Medium-Term Multi-Organ Carcinogenesis Model
• Evidence of a Threshold Dose for Promotion of Hepatocarcinogenesis by Hexachlorobenzene in a Rat Medium-Term Liver Bioassay
• P6-42 Mouse medium-term skin carcinogenesis bioassay of kojic acid(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
• A MEDIUM-TERM RAT LIVER BIOASSAY FOR RAPID IN VIVO DETECTION OF CARCINOGENIC POTENTIAL OF CHEMICALS
• Suppression of metastasis by nuclear factor кB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma
• Dose-related changes in gene expression in the livers of rats treated with sodium Phenobarbital as assessed using a three-dimensional microarray system. (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30t
• One-generation reproductive toxicity study of Fenitrothion in rats. (DEVELOPMENT AND REPRODUCTION) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• Ninety-toxicity study of annatto extract, a natural food color, in rats. (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• LACK OF CARCINOGENIC RISK IN THE PROSTATE WITH TRANSPLACENTAL AND LACTATIONAL EXPOSURE TO BISPHENOL A IN RATS
• Effects of Antioxidant 1-O-Hexy1-2,3,5-trimethylhydroquinone or Ascorbic Acid on Carcinogenesis Induced by Administration of Aminopyrine and Sodium Nitrite in a Rat Multi-organ Carcinogenesis Model
• Suppression of Lung Metastasis by Aspirin but Not Indomethacin in an in vivo Model of Chemically Induced Hepatocellular Carcinoma
• A 28-day oral toxicity study of fermentation-derived cellulose, produced by Acetobacter aceti subspecies xylinum, in F344 rats
• Cyclooxygenase 2 and Prostaglandin E2 are not Involved in N-Nitrosodiethylamine-Initiated Early Rat Hepatocarcinogenesis
• Transforming growth factor β derived from bone matrix promotes cell proliferation of prostate cancer and osteoclast activation-associated osteolysis in the bone microenvironment
• Differences in Expression Patterns of Cell Cycle Regulators after Cessation of Genotoxic and Non-genotoxic Carcinogen Treatment in the Rat Forestomach
• Prediction of carcinogenic potential by a toxicogenomic approach using rat hepatoma cells
• Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist
• Limited Effects of Disrupted Gap Junctions in the Liver on Multi-organ Carcinogenesis Induced by Diisopropanolnitrosamine in the Mutant Connexin 32 Transgenic Rat
• Carcinogenic Effects of Mixtures of Chemicals
• Downregulation of apoptosis revealed by laser microdissection and cDNA microarray analysis of related genes in rat liver preneoplastic lesions
• Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo
• High susceptibility of the ACI and spontaneously hypertensive rat (SHR) strains to 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) prostate carcinogenesis
• Suppressive Effects of Dietary Genistin and Daidzin on Rat Prostate Carcinogenesis
• Ninety-day oral toxicity study of rhamsan gum, a natural food thickener produced from Sphingomonas ATCC 31961, in Crl:CD(SD)IGS rats
• Charge Fluctuation in A_3C_(A=K and Rb) : Competition Between Electron-Electron and Electron-Phonon Interactions : Condensed Matter: Electronic Properties, etc.
• Many-Body Effects on the Density of States in Alkali-Metal-Doped C_
• 25aS-7 密度汎関数法による固体Eu@C_の電子状態計算
• 25aS-5 相対論的LCAO法によるLa@C_結晶の電子状態 II
• 24aF-3 相対論的LCAO法によるLa@C_結晶の電子状態
• 1p-YJ-8 C_8Kのフェルミ画
• 28p-S-15 固体の構造最適化と電子状態計算への量子化学的アプローチ II : 混合基底法
• 28p-S-14 固体の構造最適化と電子状態計算への量子化学的アプローチ I : LCAO法
• Electronic Coupling of Quantum-Well States in Double Ag Nanofilm Structures
• PREVENTION BY NATURAL FOOD ANTHOCYANINS, PURPLE SWEET POTATO COLOR AND RED CABBAGE COLOR, OF 2-AMINO- 1 -METHYL-6-PHENYLIMIDAZO [4,5 -b] PYRIDINE (PhIP)-ASSOCIATED COLORECTAL CARCINOGENESIS IN RATS INITIATED WITH 1,2-DIMETHYLHYDRAZINE
• Selective Extraction of Endohedral Metallofullerenes Using a Mixed Solvent of Triethylamine and Acetone
• Isolation and Characterization of a New Isomer of Ca@C_
• 25pPSA-20 Fully Relativistic Full-Potential LCAO法によるウラン化合物の磁性に関する理論的研究IV(25pPSA 領域3ポスターセッション,領域3(磁性,磁気共鳴))
• Annatto extract, a carotenoid natural food color, lacks tumor promoting effects in a medium-term liver carcinogenesis bioassay in rats (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• LACK OF SIGNIFICANT ALTERATION IN THE PROSTATE OR TESTIS OF F344 RAT OFFSPRING AFTER TRANSPLACENTAL AND LACTATIONAL EXPOSURE TO BISPHENOL A
• Effect of bisphenol A, an endocrine disruptor, on hepatocarcinogenesis and on reproductive system in medium-term liver bioassay.(GENERAL SESSION BY POSTER PRESENTATION)(ACTIVE OXYGEN ETC)
• Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats : Lack of influence of carcinogen or testosterone treatment
• DOSE-DEPENDENT INDUCTION OF CARCINOMAS AND GLUTATHIONE S-TRANSFERASE PLACENTAL FORM NEGATIVE EOSINOPHILIC FOCI IN THE RAT LIVER BY DI(2-ETHYLHEXYL)PHTHALATE AFTER DIETHYLNITROSAMINE INITIATION
• 6p-D-11 Na_xH_yC_の電子状態
• A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals
• C_ Molecular Stumbling inside Single-Walled Carbon Nanotubes
• 30pXD-3 アルカリ金属ドープC_の相図の理論的研究
• 23pS-5 動的平均場近似によるアルカリドープC_の電子状態II
• 23aZ-3 Scalar Relativistic LCAO法の新しい定式化
• A Scalar Relativistic Full-Potential LCAO Method
• 24pF-16 カリウムをドープしたグラフィンの電子構造
• 24pF-4 動的平均場近似によるアルカリドープC_の電子状態
• 24pF-3 金属ドープC_における価数と超伝導
• A Fully Relativistic Full-Potential LCAO Method for Solids
• 31a-XE-4 固体のためのfully relativistic full-potential LCAO法の開発
• 25a-M-5 グラフィンの構造最適化と電子構造
• 1p-YX-12 高圧下固体酸素の構造最適化
• 29p-D-6 (AB_4)_3C_の電子物性予測
• Electronic Coupling of Quantum-Well States in Double Ag Nanofilm Structures
• アルカリ金属ドープC60における電子間相互作用と電子格子相互作用
• Formation of Single-wall Carbon Nanotubes by Using Porous Glass
• Phase Transition in Confined Water Inside Carbon Nanotubes(Cross-disciplinary Physics and Related Areas of Science and Technology)
• Momordica charantia leaf extract suppresses rat prostate cancer progression in vitro and in vivo
• 26aPS-62 Fully Relativistic Full-Potential LCAO法によるウラン化合物の磁性に関する理論的研究V(26aPS 領域3ポスターセッション,領域3(磁性,磁気共鳴))
• Numerical Renormalization Group Study on the Non-Fermi-Liquid Behavior of Impurity Anderson Model with Non-Kramers Doublet State
• Numerical Renormalization Group Study of Non-Fermi-Liquid State on Dilute Uranium Systems
• 21aPS-75 Fully Relativistic Full-Potential LCAO法によるウラン化合物の磁性に関する理論的研究VI(21aPS 領域3ポスターセッション,領域3(磁性,磁気共鳴))
• Concordance between Results of Medium-term Liver Carcinogenesis Bioassays and Long-term Findings for Carcinogenic 2-Nitropropane and Non-carcinogenic 1-Nitropropane in F344 Rats
• Lack of Tumor Promoting Effects of Carrageenan on 1,2-Dimethylhydrazine-induced Colorectal Carcinogenesis in Male F344 Rats

もっと見る 閉じる

スポンサーリンク