Ninety-day oral toxicity study of rhamsan gum, a natural food thickener produced from Sphingomonas ATCC 31961, in Crl:CD(SD)IGS rats
スポンサーリンク
概要
- 論文の詳細を見る
This study was designed to evaluate and characterize any subchronic toxicity of rhamsan gum, a polysaccharide produced from Sphingomonas strain ATCC 31961, when administered to both sexes of Crl:CD(SD)IGS rats at dietary levels of 0 (control), 0.5, 1.5, and 5.0% (10 rats/sex/group). During the study, the treatment had no adverse effects on clinical signs, survival, body weights and food and water consumption, or on findings of urinalysis, ophthalmology, hematology, or blood biochemistry. Examination of gross pathology and histopathology exhibited no differences of toxicological significance between control and treated rats. Increased relative cecum (filled) and cecum (empty) weights, evident in males of 1.5% group and both sexes of the 5.0% group, were considered to be a physiological adaptation. Thus, the results indicated the toxic level of rhamsan gum to be more than 5.0%, and the no-observedadverse- effect level (NOAEL) was concluded to be 5.0% (3,362 mg/kg body weights/day for males, and 4,304 mg/kg body weights/day for males) from the present study.
著者
-
HAGIWARA Akihiro
DIMS Institute of Medical Science, Inc.
-
IMAI Norio
DIMS Institute of Medical Science, Inc.
-
TAMANO Seiko
DIMS Institute of Medical Science, Inc.
-
YASUHARA Kazuo
San-Ei Gen F.F.I., Inc.
-
HAYASHI Shim-mo
San-Ei Gen F.F.I., Inc.
-
Doi Yuko
DIMS Institute of Medical Science, Inc.
-
Sano Masashi
DIMS Institute of Medical Science, Inc.
-
Omoto Toshio
San-Ei Gen F.F.I., Inc.
-
Asai Iwao
San-Ei Gen F.F.I., Inc.
関連論文
- Ninety-day oral toxicity study of rhamsan gum, a natural food thickener produced from Sphingomonas ATCC 31961, in Crl:CD(SD)IGS rats
- A twenty eight-day repeated dose toxicity study of black soybean extract in Sprague-Dawley rats
- LACK OF HINOKITIOL (BETA-THUJAPLICIN) CARCINOGENICITY IN F344/DuCrj RATS
- Close Relation of Transforming Growth Factor-α Positive Hepatic Foci to Hepatocellular Tumor Development in the Rat
- Lack of Effects of Gestational and Lactational Exposure to 4-Nonylphenol on PhIP-Induced Rat Prostate Carcinogenesis
- Thirteen-Week Oral Toxicity Study of Dokudami Extract (Houttuynia Cordata Thunb.) in F344/DuCrj Rats
- Dose Dependent Promoting Effects of Hexachlorobenzene on Hepatocarcinogenesis in a Rat Medium-Term Liver Bioassay(Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Evidence of a Threshold Dose for Promotion of Hepatocarcinogenesis by Hexachlorobenzene in a Rat Medium-Term Liver Bioassay
- P6-42 Mouse medium-term skin carcinogenesis bioassay of kojic acid(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- A MEDIUM-TERM RAT LIVER BIOASSAY FOR RAPID IN VIVO DETECTION OF CARCINOGENIC POTENTIAL OF CHEMICALS
- FOUR-WEEK ORAL TOXICITY STUDY OF 1-CARBOXY-5,7-DIBROMO-6-HYDROXY-2,3,4-TRICHLOROXANTHONE (HXCA), AN IMPURITY OF PHLOXINE B, IN F344 RATS
- Dose-related changes in gene expression in the livers of rats treated with sodium Phenobarbital as assessed using a three-dimensional microarray system. (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30t
- One-generation reproductive toxicity study of Fenitrothion in rats. (DEVELOPMENT AND REPRODUCTION) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Ninety-toxicity study of annatto extract, a natural food color, in rats. (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- LACK OF CARCINOGENIC RISK IN THE PROSTATE WITH TRANSPLACENTAL AND LACTATIONAL EXPOSURE TO BISPHENOL A IN RATS
- Effects of Antioxidant 1-O-Hexy1-2,3,5-trimethylhydroquinone or Ascorbic Acid on Carcinogenesis Induced by Administration of Aminopyrine and Sodium Nitrite in a Rat Multi-organ Carcinogenesis Model
- Suppression of Lung Metastasis by Aspirin but Not Indomethacin in an in vivo Model of Chemically Induced Hepatocellular Carcinoma
- A 28-day oral toxicity study of fermentation-derived cellulose, produced by Acetobacter aceti subspecies xylinum, in F344 rats
- Establishment of an in vivo Highly Metastatic Rat Hepatocellular Carcinoma Model
- Ninety-day oral toxicity study of rhamsan gum, a natural food thickener produced from Sphingomonas ATCC 31961, in Crl:CD(SD)IGS rats
- Differences in Sensitivity of F344 Rats from Different Breeders to Phenobarbital Hepatocarcinogenicity
- Differences in susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis between SD/gShi rats with spontaneous hypospermatogenesis and SD/cShi rats with spontaneous hydronephrosis
- PREVENTION BY NATURAL FOOD ANTHOCYANINS, PURPLE SWEET POTATO COLOR AND RED CABBAGE COLOR, OF 2-AMINO- 1 -METHYL-6-PHENYLIMIDAZO [4,5 -b] PYRIDINE (PhIP)-ASSOCIATED COLORECTAL CARCINOGENESIS IN RATS INITIATED WITH 1,2-DIMETHYLHYDRAZINE
- Susceptibility of Four F_1 Hybrids of Male Rats to the Promoting Effects of Sodium L-ascorbate in Two-Stage Urinary Bladder Carcinogenesis
- Decrease of Prostaglandin E_2 and 5-Bromo-2'-deoxyuridine Labeling but Not Prostate Tumor Development by Indomethacin Treatment of Rats Given 3,2'-Dimethyl-4-aminobiphenyl and Testosterone Propionate
- Modification by Analgesics of Lesion Development in the Urinary Tract and Various Other Organs of Rats Pretreated with Dihydroxy-di-N-propylnitrosamine and Uracil
- Characteristics of New Contact Plate Prepared with Native Gellan Gum
- Influence of Strain and Diet on Hepatocarcinogenicity of N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in Rats : Slight Inhibition of Preneoplastic Liver Lesion Development by Uracil
- Annatto extract, a carotenoid natural food color, lacks tumor promoting effects in a medium-term liver carcinogenesis bioassay in rats (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- 90-day repeated dose toxicity study of gum arabic(General toxicity, Proceedings of the 32nd Annual Meeting)
- LACK OF SIGNIFICANT ALTERATION IN THE PROSTATE OR TESTIS OF F344 RAT OFFSPRING AFTER TRANSPLACENTAL AND LACTATIONAL EXPOSURE TO BISPHENOL A
- Effect of bisphenol A, an endocrine disruptor, on hepatocarcinogenesis and on reproductive system in medium-term liver bioassay.(GENERAL SESSION BY POSTER PRESENTATION)(ACTIVE OXYGEN ETC)
- RELIABILITY AND PRACTICALITY OF MEDIUM-TERM CARCINOGENESIS BIOASSAYS(WORKSHOP 4 : NEW TECHNOLOGY AND EVALUATIONS OF IN VIVO TOXICITY STUDIES)
- DOSE-RELATED INCREASES IN QUANTITATIVE VALUES FOR GLUTATHIONE S-TRANSFERASE PLACENTAL FORM (GST-P) POSITIVE FOCI AND CYTOCHROME P-450 LEVELS IN THE LIVER OF F344 RATS EXPOSED TO PHENOBARBITAL SODIUM (PB) IN A MEDIUM-TERM BIOASSAY
- Effects of Gelling Agents on in Vitro Culture of Plant Tissues
- Site-specific Effects of Testosterone Propionate on the Prostate of Rat Pretreated with 3,2'-Dimethyl-4-aminobiphenyl : Dose-dependent Induction of Invasive Carcinomas
- Beef Tallow, but Not Perilla or Corn Oil, Promotion of Rat Prostate and Intestinal Carcinogenesis by 3,2'-Dimethyl-4-aminobiphenyl
- DOSE-DEPENDENT INDUCTION OF CARCINOMAS AND GLUTATHIONE S-TRANSFERASE PLACENTAL FORM NEGATIVE EOSINOPHILIC FOCI IN THE RAT LIVER BY DI(2-ETHYLHEXYL)PHTHALATE AFTER DIETHYLNITROSAMINE INITIATION
- 21C-10-5 Effect of Hepatocarcinogenesis of Tamoxifen in the Medium-term Liver Bioassay (Ito Model).
- 3A-07 Muiti-Organ Carcinogenesis Bioassay of Quinoid Madder Colors
- A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals
- A Potential Use of a Synthetic Retinoid TAC-101 as an Orally Active Agent That Blocks Angiogenesis in Liver Metastases of Human Stomach Cancer Cells
- Antitumor Activity of a Novel Quinoline Derivative, TAS-103, with Inhibitory Effects on Topoisomerases I and II
- INDUCTION OF HEPATIC CYP2B1/2 BY A TERATOGENIC COMPOUND cis-1-[-4-P-MENTHANE-8-YLOXY)PHENYL]PIPERADINE(YM9429)IN RATS
- Selective Inhibition of Chondrogenic Differentiation in Embryonic Cells by a Teratogenic Compound
- A SIMPLE METHOD FOR SCREENING ASSESSMENT OF SKIN AND EYE IRRITATION
- Sub-acute oral toxicity study with fullerene C60 in rats
- Concordance between Results of Medium-term Liver Carcinogenesis Bioassays and Long-term Findings for Carcinogenic 2-Nitropropane and Non-carcinogenic 1-Nitropropane in F344 Rats
- Lack of Tumor Promoting Effects of Carrageenan on 1,2-Dimethylhydrazine-induced Colorectal Carcinogenesis in Male F344 Rats