INDUCTION OF HEPATIC CYP2B1/2 BY A TERATOGENIC COMPOUND cis-1-[-4-P-MENTHANE-8-YLOXY)PHENYL]PIPERADINE(YM9429)IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
A teratogenic compound cis-1-[-4-(p-menthane-8-yloxy)phenyl]piperadine (YM9429)selectively induces skeletal malformations characterized by cleft palate in rat fetuses. In the present study, we investigated the effect of YM9429 on hepatic cytochrome P-450s and their activities in rats. Oral administrations of YM9429 at a dose of 250, 500 or 750 mg / kg daily for 3 days induced cytochrome P-450 contents in a dose-dependent manner. Concomitant induction of enzyme activities of benzphetamine N-demethylase, erythromycin N-demethylase and, to a lesser extent, aminopyrine N-demethylase was observed. Immunoblot analysis revealed that YM9429 up-regulated hepatic levels of CYP2B1 / 2 and CYP3A1 / 2 proteins. A single dose of YM9429 at 250 mg / kg induced CYP2B1 / 2 protein levels significantly. These results suggest that YM9429 is a strong inducer of cytochrome P-450 with characteristics resembling those of phenobarbital.
- 日本トキシコロジー学会の論文
- 2000-02-28
著者
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FUNAE Yoshihiko
Department of Chemical Biology, Osaka City University Graduate School of Medicine
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Sano Masashi
DIMS Institute of Medical Science, Inc.
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NUMAZAWA Satoshi
Department of Biochemical Toxicology, School of Pharmacy, Showa University
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YOSHIDA Takemi
Department of Biochemical Toxicology, School of Pharmacy, Showa University
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IMAOKA Susumu
Laboratory of Chemistry, Osaka City University Medical School
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FUNAE Yoshihiko
Laboratory of Chemistry, Osaka City University Medical School
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Yoshida Tomoko
Department Of Nuclear Engineering Nagoya University
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Yoshida Takemi
Dept.biochem.toxicol. Showa Univ.
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Yoshida T
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
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Yoshida Takemi
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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Yoshida T
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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SHIBATA Masa-Aki
Daiyu-kai Institute of Medical Science
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Numazawa Satoshi
Dep. Of Biochemical Toxicology School Of Pharmacy Showa Univ.
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Numazawa Satoshi
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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Numazawa Satoshi
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
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Yoshida Takemi
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
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Funae Y
Osaka City Univ. Medical School Osaka Jpn
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Funae Yoshihiko
Department Of Chemical Biology Osaka City University Graduate School Of Medicine
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Funae Yoshihiko
Laboratory Of Chemistry Osaka City University
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Yoshida Teiji
Department Of Physics Faculty Of Science Tohoku University
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Yoshida Takahiko
Department Of Environmental Health Division Of Community And Environmental Health Tokai University S
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Imaoka S
Nanobiotechnology Research Center And Department Of Bioscience School Of Science And Technology Kwan
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Imaoka Susumu
Department Of Bioscience And Nanobiotechnology Research Center School Of Science And Technology Kwan
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Imaoka Susumu
Laboratory Of Chemistry Osaka City University
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Yoshida Takemi
School Of Pharmaceutical Sciences Showa University
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SHIBATA Masakatsu
Development Strategy Department, Yamanouchi Pharmaceutical Co., Ltd.
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Shibata Michiko
Development Strategy Department Yamanouchi Pharmaceutical Co. Ltd.
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Yoshida Takemi
Pfizer Japan Inc. Drug Safety R&d Pfizer Global R&d
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Yoshida Tomoko
Department of Biochemical Toxicology, School of Pharmacy Showa University
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