SALIVA LEVELS OF TRIMETHADIONE AND ITS METABOLITE AS AN INDEX OF DRUG METABOLIZING ACTIVITY IN RATS
スポンサーリンク
概要
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1. It was investigated in normal and liver-injured rats administered with trimethadione (TMO) as to whether concentrations of TMO in plasma are able to be predicted from the corresponding saliva levels. 2. The saliva/plasma (S/P) ratio of TMO was about 1,while its metabolite 5,5-dimethyl-2,4-oxazolidinedione (DMO) showed a S/P ratio of 0.65. 3. In normal rats, there was a high correlation between saliva and plasma concentration of TMO and DMO. (TMO : r=0.966,DMO : r=0.950) 4. In liver-injured pretreated rats with carbon tetrachloride, α-naphthyl isothiocyanate or D-galactosamine, there was a high correlation between the saliva DMO/TMO ratio and the plasma DMO/TMO raito after oral administration of TMO (r=0.983 at 1 h, r=0.952 at 2 h). 5. The saliva DMO/TMO ratio, as well as the plasma DMO/TMO ratio, may be utilized as an index of drug-metabolizing activity of the liver.
- 公益社団法人日本薬学会の論文
著者
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YOSHIDA Takemi
Department of Biochemical Toxicology, School of Pharmacy, Showa University
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TANAKA EINOSUKE
Department of Legal Medicine, Institute of Community Medicine
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KUROIWA YUKIO
Department of Biochemical Toxicology, School of Pharmaceutical Science Showa University
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Kuroiwa Y
Experimental Toxicology Group Sandoz Research Laboratory
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Kuroiwa Yukio
Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University
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Kuroiwa Yukio
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
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Yoshida Takemi
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
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KINOSHITA HARUKI
Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University
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Tanaka Einosuke
Institute Of Community Medicine And Institute Of Clinical Medicine University Of Tsukuba
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Yoshida Takahiko
Department Of Environmental Health Division Of Community And Environmental Health Tokai University S
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Kuroiwa Y
Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University
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Tanaka Einosuke
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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Yoshida Takemi
Pfizer Japan Inc. Drug Safety R&d Pfizer Global R&d
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Kinoshita Haruki
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
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