The effect of H2-receptor antagonists on antipyrine and pentobarbital metabolism in male and female rats.
スポンサーリンク
概要
- 論文の詳細を見る
Pretreatment of male and female rats with cimetidine decreased the amount of 3-hydroxymethylantipyrine in the 24-hr urine, but urinary antipyrine and 4-hydroxyantipyrine were increased compared to that of the corresponding control rats. On the other hand, the amount of norantipyrine and the total amount of antipyrine and its metabolites were not changed by cimetidine, ranitidine and famotidine. These data suggest that ranitidine and famotidine have little effect on the microsomal mixed function oxidase system in male and female rats.
- 公益社団法人 日本薬理学会の論文
著者
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Misawa Shogo
Institute Of Community Medicine University Of Tsukuba
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Kuroiwa Yukio
Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University
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Tanaka Einosuke
Institute Of Community Medicine And Institute Of Clinical Medicine University Of Tsukuba
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KUROIWA Yukio
Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University
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NAKAMURA Koichi
Institute of Clinical Medicine, University of Tsukuba
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MISAWA Shogo
Institute of Community Medicine
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