Early effects of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene on mitochondrial outer membrane enzyme activities of rat liver.
スポンサーリンク
概要
- 論文の詳細を見る
During the early stages of the carcinogen 2-acetylaminofluorene (2-AAF) feeding, there were marked decreases of hepatic mitochondrial type B monoamine oxidase (MAO) and kynurenine 3-hydroxylase activities in male rats, but not in female rats. The administration of N-hydroxy-2-AAF (N-OH-2-AAF), a proximate carcinogenic metabolite of 2-AAF, to male rats also resulted in the decrease of both enzyme activities. The findings indicate that type B MAO and kynurenine 3-hydroxylase which reside in the outer mitochondrial membranes are susceptible to 2-AAF during the early stages of its hepatocarcinogenesis.
- 公益社団法人 日本薬理学会の論文
著者
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Yamamoto Toshinori
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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Kuroiwa Yukio
Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University
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Yoshida Takemi
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
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MATSUURA YOICHI
Department of Hygienic Chemistry, Showa College of Pharmaceutical Sciences
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YAMAMOTO Toshinori
Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University
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