SELECTIVE EFFECT OF CHRONIC LEAD INGESTION II : EFFECT ON PHENYLETHANOLAMINE N-METHYLTRANSFERASE ACTIVITY IN BRAIN REGIONS OF RATS
スポンサーリンク
概要
- 論文の詳細を見る
Selectivity of lead effect to phenylethanolamine N-methyltransferase (PNMT) activity in regions of brain from rats postnatally exposed to lead was tested. Three groups of animals were prepared; (1) Rats exposed to lead at a low dose (0.05% PbAcetate: PbAc); (2) Rats exposed to lead at a high dose (0.2% PbAc); (3) Age-matched normal control rats. At 2, 4, 6 and 8 weeks of age weight of whole brain and body in each group were measured. At the same age activities of PNMT and Na^+/K^+-ATPase were examined on 4 brain regions of each animal. Exposure of rats to lead generally decreased activity of Na^+/K^+-ATPase and showed alternative change of those of PNMT. Brain regions where changes of PNMT activity were detected without concomitant changes of Na^+/K^+-ATPase activity, were telencephalon and pons/medulla at 2 weeks of age and telencephalon at 4 weeks of age in rats exposed to lead at a low dose, and those in rats exposed to lead at a high dose were pons/medulla at 8 weeks of age. These data imply that adrenergic nervous system in the brain regions described above could selectively be affected by lead.
- 日本トキシコロジー学会の論文
- 1993-02-25
著者
-
LEE Chung
Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of
-
KUROIWA YUKIO
Department of Biochemical Toxicology, School of Pharmaceutical Science Showa University
-
Kuroiwa Y
Experimental Toxicology Group Sandoz Research Laboratory
-
Kuroiwa Yukio
Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University
-
Kuroiwa Yukio
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
-
KO Kwang
Department of Electrical and Electronic Engineering, Faculty of Engineering, Tokyo Institute of Tech
-
CHIN Kang
National Institute of Safety Research
-
Ko Kwang
Department Of Pharmacology College Of Pharmacy Seoul National University
-
Ko Kwang
Department Of Electrical And Electronic Engineering Faculty Of Engineering Tokyo Institute Of Techno
-
Kuroiwa Y
Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University
-
Lee Chung
Department Of Pharmacology College Of Pharmacy Seoul National University
-
SEO Kong
Department of Pharmacology, College of Pharmacy, Seoul National University
-
Seo Kong
Department Of Pharmacology College Of Pharmacy Seoul National University
-
Lee Chung
Department Of Anesthesiology And Pain Medicine Asan Medical Center University Of Ulsan College Of Me
-
Ko Kwang
韓国
-
KO Kwang
Departmemt of Mechatronics, Gwangju Institute of Science and Technology
関連論文
- Decrease in the Kainate-Induced Wet Dog Shake Behavior in Genetically Epilepsy-Prone Rats : Possible Involvement of an Impaired Synaptic Transmission to the 5-HT_ Receptor
- Effects of Bilateral Stellate Ganglion Block on Autonomic Cardiovascular Regulation
- THE EFFECT OF INDOMETHACIN ON HEPATIC DRUG-OXIDIZING CAPACITY IN THE RAT : TRIMETHADIONE AND ANTIPYRINE METABOLISM AS AN INDICATOR
- A METHOD FOR ESTIMATION OF HEPATIC DRUG-METABOLIZING CAPACITY : DETERMINATION OF CONCENTRATION OF TRIMETHADIONE AND ITS METABOLITE IN HUMAN SERUM
- Plasma Behavior in Reversed-Field Pinch Configuration
- SELECTIVE EFFECT OF CHRONIC LEAD INGESTION III : EFFECT ON DOPAMINE β-HYDROXYLASE ACTIVITY IN BRAIN REGIONS OF RATS
- The Impact of Titanium Silicide on the Contact Resistance for Shallow Junction Formed by Out-Diffusion of Arsenic from Polysilicon
- SELECTIVE EFFECT OF CHRONIC LEAD INGESTION ON TYROSINE HYDROXYLASE ACTIVITY IN BRAIN REGIONS OF RATS
- Uridine prevents the glucose deprivation-induced death of immunostimulated astrocytes via the action of uridine phosphorylase
- PHARMACOKINETIC STUDIES OF TRIMETHADIONE AND ITS METABOLITE IN RATS WITH CHEMICAL-INDUCED LIVER INJURY
- A USEFUL MEASURE OF HEPATIC DRUG METABOLISM : TRIMETHADIONE ELIMINATION AS AN INDICATOR
- Characterization of Novel HfTiO Gate Dielectrics Post-treated by NH_3 Plasma and Ultra-violet Rays
- Improvement of Reliability of Metal-Oxide Semiconductor Field-Effect Transistors with N_2O Nitrided Gate Oxide and N_2O Polysilicon Gate Reoxidation
- Establishment and Peculiarity of Ouabain-resistant THP-1 cells
- COMPARISON OF THE EFFECT OF AN EQUIMOLAR AND LOW DOSE OF FENITROTHION AND METHYLPARATHION ON THEIR OWN METABOLISM IN RAT LIVER
- PROTECTIVE EFFECTS OF DIISOPROPYL 1, 3-DITHIOL-2-YLIDENE MALONATE (NKK-105) ON LIVER INJURY BY CARBON TETRACHLORIDE (CCl_4)
- ALTERATIONS OF HEPATIC MITOCHONDRIAL MONOAMINE OXIDASE ACTIVITY OF RATS DURING 2-ACETYLAMINOFLUORENE FEEDING
- Antigenic characterization in ampiroxicam-induced photosensitivity using an in vivo model of contact hypersensitivity
- Gastrointestinal Stromal Tumor of the Rectum : An Analysis of Seven Cases
- STUDIES ON THE MECHANISM OF INTERACTION BETWEEN METHAMPHETAMINE AND QUININE IN RATS
- Selective Inhibition of Chondrogenic Differentiation in Embryonic Cells by a Teratogenic Compound
- Possible Role of Glutathione Depletion in the Induction of Rate-Limiting Enzymes Involved in Heme Degradation and Polyamine Biosynthesis in the Liver of Rats
- Comparative Studies on the Inducing Effects of Cobalt Chloride and Co-Protoporphyrin on Hepatic Ornithine Decarboxylase and Heme Oxygenase in Rats
- DEPLETION OF HEPATIC GLUTATHIONE IS FOLLOWED BY THE INDUCTION OF HEME OXYGENASE AND CHANGES IN DRUG-METABOLIZING ENZYMES
- Relationship between Hepatic Glutathione Consumption and the Induction of Enzymes Involved in Polyamine Biosynthesis Evoked by Various Drugs and Chemicals (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
- EVALUATION OF THE INDUCTION OF HEPATIC DRUG-METABOLIZING ENZYMES IN THE RAT AND MOUSE TREATED WITH TEMAZEPAM USING TRIMETHADIONE AS THE INDICATOR
- RELATIONSHIP BETWEEN TRIMETHADIONE METABOLISM AND HEPATIC DRUG-OXIDIZING ENZYME ACTIVITIES IN DIFFERENT ANIMAL SPECIES
- STUDIES ON THE TRIMETHADIONE METABOLISM AS A TOOL FOR THE ASSESSMENT OF DRUG-METABOLIZING CAPACITY USING PLASMA AND URINE OF RATS PRETREATED WITH PHENOBARBITAL AND 3-METHYLCHOLANTHRENE
- DETERMINATION OF PLASMA TRIMETHADIONE AND ITS METABOLITE IN CARBON TETRACHLORIDE-INTOXICATED RATLIVER : A USEFUL TOOL FOR ESTIMATION OF HEPATIC DRUGMETABOLIZING CAPACITY
- SALIVA LEVELS OF TRIMETHADIONE AND ITS METABOLITE AS AN INDEX OF DRUG METABOLIZING ACTIVITY IN RATS
- Hydrogen and Oxygen Plasma Effects on Polycrystalline Silicon Thin Films of Various Thicknesses
- Rharmacokinetics of Cephaeline and Emetine in Ipecac Syrup in Rats and Dogs
- Effects of BCl_3 Passivation on Pt/Al/n-InP Diodes
- Measurement of Thin Oxide Films on Implanted Si-Substrate by Ellipsometry
- Suppression of Boron Penetration in BF^+_2-Implanted Poly-Si Gate
- Evidence that protease-activated receptor-2 mediates trypsin-induced reversal of stellation in cultured rat astrocytes
- Suppression of Boron Pemetration in PMOS by Using Oxide Gettering Effect in Poly-Si Gate
- A SUSTAINED INCREASE OF MICROSOMAL HEME OXYGENASE ACTIVITY FOLLOWING TREATMENT OF RATS WITH BACILLUS CALMETTE-GUERIN AND CORYNEBACTERIUM PARVUM : ITS POSSIBLE RELATION TO THE DECREASE OF CYTOCHROME P-450 CONTENT
- ALTERATIONS OF HEPATIC δ-AMINOLEVULINIC ACID SYNTHETASE, HEME OXYGENASE, MICROSOMAL CYTOCHROME CONTENT AND DRUG METABOLISM IN RATS BEARING ASCITIC TUMORS AH 13,AH 66 AND AH 414 AND A 3-METHYLCHOLANTHRENE INDUCED TUMOR
- INDUCTION OF HEME OXYGENASE AND INHIBITION OF δ-AMINOLEVULINIC ACID SYNTHETASE OF RAT LIVER BY THIOACETAMIDE AND THIOACETAMIDE-S-OXIDE
- SELECTIVE EFFECT OF CHRONIC LEAD INGESTION II : EFFECT ON PHENYLETHANOLAMINE N-METHYLTRANSFERASE ACTIVITY IN BRAIN REGIONS OF RATS
- 2-2) Behavioral Teratogenicity of Methamphetamine
- Protective effect of adenosine and purine nucleos(t)ides against the death by hydrogen peroxide and glucose deprivation in rat primary astrocytes
- UV Radiation of a Pulsed Discharge Using Needle-to-Plane Electrodes
- N-methylated β-carbolines protect PC12 cells from cytotoxic effect of MPP^+ by attenuation of mitochondrial membrane permeability change
- Neurotoxicological Alterations Induced by N-buty1 benzenesulfonamide and Aluminum Chloride in Wistar Rats
- SIMULTANEOUS INDUCTION OF ORNITHINE DECARBOXYLASE AND HEME OXYGENASE UNDER VARIOUS EXPERIMENTAL CONDITIONS
- EFFECTS OF METHAMPHETAMINE HYDROCHLORIDE ON NEUROLOGICAL FUNCTION IN RATS
- 214 Effects of Cocaine Hydrochloride on Dopaminergic System of the Brain in Rats
- POTENTIATION OF AFLATOXIN B_1 INDUCED HEPATOTOXICITY IN MALE WISTAR RATS WITH ETHANOL PRETREATMENT
- AN INDUCTION OF HEME OXYGENASE AND ITS POSSIBLE RELATION TO THE DECREASE OF CYTOCHROME P-450 CONTENT DURING LIVER REGENERATION
- ALTERATIONS OF DRUG AND HEME METABOLIZING ENZYMES DURING LIVER REGENERATION
- EFFECT OF HEAVY METALS ON SOME ENZYMES OF RAT LIVER AND FACTORS WHICH MODIFY THE METAL ACTIONS, ESPECIALLY OF CADMIUM
- INHIBITION OF MONOAMINE OXIDASE BY 3-METHYL-4-DIMETHYLAMINO AZOBENZENE (3-Me-DAB) IN RAT LIVER MITOCHONDRIA
- EFFECTS OF PASSIVE IMMUNIZATION WITH RABBIT ANTI-PHENOBARBITAL IgG ON CYCLOBARBITAL-INDUCED SLEEPING TIME AND HEPATIC ENZYME ACTIVITIES OF C3H MICE
- Effect of Ambient Temperature on the MA and MG Processes in Ni-Zr Alloy System
- TRIMETHADIONE AS A MODEL DRUG FOR THE EVALUATION OF HEPATIC DRUG-METABOLIZING CAPACITY IN NORMAL AND D-GALACTOSAMINE INTOXICATED RATS
- Effects of BCl3 Passivation on Pt/Al/n-InP Diodes
- PRODUCTION OF TOLERANCE TO FENITROTHION I N MALE RATS
- Hirsutenone Directly Blocks Human ether-a-go-go Related Gene K+ Channels
- The effect of H2-receptor antagonists on antipyrine and pentobarbital metabolism in male and female rats.
- Early effects of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene on mitochondrial outer membrane enzyme activities of rat liver.
- Temporal Behaviors of Flash X-Ray Source Driven by a Low-Energy Capacitor Discharge
- The role of vagal reflex in mechanism of secretagogic action of bromhexine.
- Dynamic Evolution of Information Complexity for Analysis of Design and Development