EVALUATION OF THE INDUCTION OF HEPATIC DRUG-METABOLIZING ENZYMES IN THE RAT AND MOUSE TREATED WITH TEMAZEPAM USING TRIMETHADIONE AS THE INDICATOR

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概要

• 論文の詳細を見る

• In the present paper we report the effect of high doses of temazepam on drug-metabolism induction in rat and mouse. Temazepam induced a dose-dependent and reversible increase of hepatic microsomal drug-metabolizing enzymes in the rat, dose-correlated increase of dimethadione / trimethadione ratios in plasma of the rat, and dose-related shortening of hexobarbital-induced sleeping time in the mouse. In this study trimethadione is considered a good indicator for estimating the state of hepatic enzyme induction.

• 日本トキシコロジー学会の論文
• 1985-02-25

著者

• YOSHIDA Takemi

  Department of Biochemical Toxicology, School of Pharmacy, Showa University

• TANAKA EINOSUKE

  Department of Legal Medicine, Institute of Community Medicine

• KUROIWA YUKIO

  Department of Biochemical Toxicology, School of Pharmaceutical Science Showa University

• Kuroiwa Y

  Experimental Toxicology Group Sandoz Research Laboratory

• Kuroiwa Yukio

  Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University

• Kuroiwa Yukio

  Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University

• Yoshida Tomoko

  Department Of Nuclear Engineering Nagoya University

• Yoshida T

  Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University

• Yoshida Takemi

  Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University

• Yoshida Teiji

  Department Of Physics Faculty Of Science Tohoku University

• Tanaka Einosuke

  Institute Of Community Medicine And Institute Of Clinical Medicine University Of Tsukuba

• Yoshida Takahiko

  Department Of Environmental Health Division Of Community And Environmental Health Tokai University S

• Kitagawa Yukio

  Experimental Toxicology Group Sandoz Research Laboratory

• Kuroiwa Y

  Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University

• Matsuda Katsuichi

  Toxicological Research Department Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Yoshida Takemi

  School Of Pharmaceutical Sciences Showa University

• KATAHIRA Masaaki

  Experimental Toxicology Group, Sandoz Research Laboratory

• MATSUDA Katsuichi

  Experimental Toxicology Group, Sandoz Research Laboratory

• Tanaka Einosuke

  Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University

• Katahira Masaaki

  Experimental Toxicology Group Sandoz Research Laboratory

• Yoshida Tomoko

  Department of Biochemical Toxicology, School of Pharmacy Showa University

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