INDUCTION OF HEME OXYGENASE AND INHIBITION OF δ-AMINOLEVULINIC ACID SYNTHETASE OF RAT LIVER BY THIOACETAMIDE AND THIOACETAMIDE-S-OXIDE
スポンサーリンク
概要
- 論文の詳細を見る
Thioacetamide and one of its metabolite, thioacetamide-S-oxide, were shown to increase heme oxygenase and to inhibit δ-aminolevulinic acid (ALA) synthetase when administered in vivo to male rats. Concomitant with the increase of heme oxygenase and the decrease of ALA synthetase, concentration of cytochrome P-450 and drug metabolizing enzyme activities were decreased by in vivo administration of thioacetamide and thioacetamide-S-oxide to rats. The results of these studies indicate that thioacetamide and thioacetamide-S-oxide are not only inhibitor of ALA synthetase, but also inducer of heme oxygenase in rats. Further, thioacetamide-S-oxide is generally more effective than thioacetamide with respect to the effects on cytochrome P-450,ALA synthetase and heme oxygenase
- 公益社団法人日本薬学会の論文
著者
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YOSHIDA Takemi
Department of Biochemical Toxicology, School of Pharmacy, Showa University
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KUROIWA YUKIO
Department of Biochemical Toxicology, School of Pharmaceutical Science Showa University
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Kuroiwa Yukio
Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University
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Yoshida Takemi
Department Of Clinical Cariology And Endodontology Showa University School Of Dentistry
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Yamashita T
Dept. Biochem. & Mol. Biol. Fac. Sci. Saitama Univ.
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Yoshida Takemi
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
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Fukuda Teruo
Department of Radiology, Osaka City Univ., Medical School.
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Fukuda Teruo
Department Of Hygienic Chemistry Showa College Of Pharmaceutical Sciences
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Takizawa Yoko
Department Of Hygienic Chemistry Showa College Of Pharmaceutical Sciences
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MATSUURA YOICHI
Department of Hygienic Chemistry, Showa College of Pharmaceutical Sciences
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