A SUSTAINED INCREASE OF MICROSOMAL HEME OXYGENASE ACTIVITY FOLLOWING TREATMENT OF RATS WITH BACILLUS CALMETTE-GUERIN AND CORYNEBACTERIUM PARVUM : ITS POSSIBLE RELATION TO THE DECREASE OF CYTOCHROME P-450 CONTENT
スポンサーリンク
概要
- 論文の詳細を見る
The alterations of various enzymes responsible for drug metabolism and heme metabolism were examined in the liver of female rats treated with Bacillus Calmette-Guerin (BCG) and Corynebacterium parvum (CP). Hepatic drug metabolizing enzyme activities and microsomal cytochrome P-450 and b_5 content were significantly decreased for up to 15 and 10 d by a single i.v. administration of BCG and CP, respectively. In contrast, microsomal heme oxygenase activity was markedly increased after BCG and CP treatment and the increased enzyme activity was sustained in parallel with the decrease of drug metabolizing enzymes. Both BCG and CP also caused a significant decrease of δ-aminolevulinic acid synthetase activity shortly after their administrations. The decreased enzyme activity returned to normal levels by 12 h after the treatment of rats with BCG and CP. In addition, hepatosplenomegaly was observed in BCG and CP treated rats. Dose related changes of these microsomal enzymes were seen following the administration of BCG and CP. Additionally, there were sex differences in the effects of BCG and CP on the alteration of microsomal enzymes, female rats being more sensitive than male rats. These results suggest that the decrease of cytochrome P-450 and b_5 content and drug metabolizing enzyme activities by BCG and CP could be related, at least in part, to the prolonged increase of heme oxygenase activity, that may lead to the increased breakdown of heme available for the synthesis of these hemoproteins.
- 公益社団法人日本薬学会の論文
著者
-
KUROIWA YUKIO
Department of Biochemical Toxicology, School of Pharmaceutical Science Showa University
-
Kuroiwa Yukio
Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University
-
Yoshida Takemi
Department Of Clinical Cariology And Endodontology Showa University School Of Dentistry
-
Yamashita T
Dept. Biochem. & Mol. Biol. Fac. Sci. Saitama Univ.
-
Fukuda Teruo
Department of Radiology, Osaka City Univ., Medical School.
-
Fukuda Teruo
Department Of Hygienic Chemistry Showa College Of Pharmaceutical Sciences
関連論文
- THE EFFECT OF INDOMETHACIN ON HEPATIC DRUG-OXIDIZING CAPACITY IN THE RAT : TRIMETHADIONE AND ANTIPYRINE METABOLISM AS AN INDICATOR
- A METHOD FOR ESTIMATION OF HEPATIC DRUG-METABOLIZING CAPACITY : DETERMINATION OF CONCENTRATION OF TRIMETHADIONE AND ITS METABOLITE IN HUMAN SERUM
- Guinea Pig Maximization Test of Tri-ethylene Glycol Mono-methacrylate
- The Efficacy of the Dentin Adhesive to the Caries-affected Dentin
- Detection of Bisphenol-A in Dental Materials by Gas Chromatography-Mass Spectrometry
- Effect of 10% Phosphoric acid Conditioning on the Efficacy of a Dentin Bonding System
- Effectiveness of Simplified Dentin Bonding Systems
- SELECTIVE EFFECT OF CHRONIC LEAD INGESTION III : EFFECT ON DOPAMINE β-HYDROXYLASE ACTIVITY IN BRAIN REGIONS OF RATS
- DIAGNOSIS OF ANEURYSM OF THE THORACIC AORTA BY NUCLEAR ANGIOCARDIOGRAPHY : IInd Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- SELECTIVE EFFECT OF CHRONIC LEAD INGESTION ON TYROSINE HYDROXYLASE ACTIVITY IN BRAIN REGIONS OF RATS
- PHARMACOKINETIC STUDIES OF TRIMETHADIONE AND ITS METABOLITE IN RATS WITH CHEMICAL-INDUCED LIVER INJURY
- A USEFUL MEASURE OF HEPATIC DRUG METABOLISM : TRIMETHADIONE ELIMINATION AS AN INDICATOR
- Establishment and Peculiarity of Ouabain-resistant THP-1 cells
- COMPARISON OF THE EFFECT OF AN EQUIMOLAR AND LOW DOSE OF FENITROTHION AND METHYLPARATHION ON THEIR OWN METABOLISM IN RAT LIVER
- PROTECTIVE EFFECTS OF DIISOPROPYL 1, 3-DITHIOL-2-YLIDENE MALONATE (NKK-105) ON LIVER INJURY BY CARBON TETRACHLORIDE (CCl_4)
- ALTERATIONS OF HEPATIC MITOCHONDRIAL MONOAMINE OXIDASE ACTIVITY OF RATS DURING 2-ACETYLAMINOFLUORENE FEEDING
- Antigenic characterization in ampiroxicam-induced photosensitivity using an in vivo model of contact hypersensitivity
- STUDIES ON THE MECHANISM OF INTERACTION BETWEEN METHAMPHETAMINE AND QUININE IN RATS
- Bisphenol-A contents in materials used in pediatric dentistry
- Selective Inhibition of Chondrogenic Differentiation in Embryonic Cells by a Teratogenic Compound
- Possible Role of Glutathione Depletion in the Induction of Rate-Limiting Enzymes Involved in Heme Degradation and Polyamine Biosynthesis in the Liver of Rats
- Comparative Studies on the Inducing Effects of Cobalt Chloride and Co-Protoporphyrin on Hepatic Ornithine Decarboxylase and Heme Oxygenase in Rats
- DEPLETION OF HEPATIC GLUTATHIONE IS FOLLOWED BY THE INDUCTION OF HEME OXYGENASE AND CHANGES IN DRUG-METABOLIZING ENZYMES
- Relationship between Hepatic Glutathione Consumption and the Induction of Enzymes Involved in Polyamine Biosynthesis Evoked by Various Drugs and Chemicals (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
- EVALUATION OF THE INDUCTION OF HEPATIC DRUG-METABOLIZING ENZYMES IN THE RAT AND MOUSE TREATED WITH TEMAZEPAM USING TRIMETHADIONE AS THE INDICATOR
- RELATIONSHIP BETWEEN TRIMETHADIONE METABOLISM AND HEPATIC DRUG-OXIDIZING ENZYME ACTIVITIES IN DIFFERENT ANIMAL SPECIES
- STUDIES ON THE TRIMETHADIONE METABOLISM AS A TOOL FOR THE ASSESSMENT OF DRUG-METABOLIZING CAPACITY USING PLASMA AND URINE OF RATS PRETREATED WITH PHENOBARBITAL AND 3-METHYLCHOLANTHRENE
- DETERMINATION OF PLASMA TRIMETHADIONE AND ITS METABOLITE IN CARBON TETRACHLORIDE-INTOXICATED RATLIVER : A USEFUL TOOL FOR ESTIMATION OF HEPATIC DRUGMETABOLIZING CAPACITY
- SALIVA LEVELS OF TRIMETHADIONE AND ITS METABOLITE AS AN INDEX OF DRUG METABOLIZING ACTIVITY IN RATS
- 334. Study on Formulation of Criteria for Appropriate Period of Initiating hCG Medication in Gonadotropin Therapy
- Rharmacokinetics of Cephaeline and Emetine in Ipecac Syrup in Rats and Dogs
- A SUSTAINED INCREASE OF MICROSOMAL HEME OXYGENASE ACTIVITY FOLLOWING TREATMENT OF RATS WITH BACILLUS CALMETTE-GUERIN AND CORYNEBACTERIUM PARVUM : ITS POSSIBLE RELATION TO THE DECREASE OF CYTOCHROME P-450 CONTENT
- ALTERATIONS OF HEPATIC δ-AMINOLEVULINIC ACID SYNTHETASE, HEME OXYGENASE, MICROSOMAL CYTOCHROME CONTENT AND DRUG METABOLISM IN RATS BEARING ASCITIC TUMORS AH 13,AH 66 AND AH 414 AND A 3-METHYLCHOLANTHRENE INDUCED TUMOR
- INDUCTION OF HEME OXYGENASE AND INHIBITION OF δ-AMINOLEVULINIC ACID SYNTHETASE OF RAT LIVER BY THIOACETAMIDE AND THIOACETAMIDE-S-OXIDE
- SELECTIVE EFFECT OF CHRONIC LEAD INGESTION II : EFFECT ON PHENYLETHANOLAMINE N-METHYLTRANSFERASE ACTIVITY IN BRAIN REGIONS OF RATS
- SIMULTANEOUS INDUCTION OF ORNITHINE DECARBOXYLASE AND HEME OXYGENASE UNDER VARIOUS EXPERIMENTAL CONDITIONS
- POTENTIATION OF AFLATOXIN B_1 INDUCED HEPATOTOXICITY IN MALE WISTAR RATS WITH ETHANOL PRETREATMENT
- AN INDUCTION OF HEME OXYGENASE AND ITS POSSIBLE RELATION TO THE DECREASE OF CYTOCHROME P-450 CONTENT DURING LIVER REGENERATION
- ALTERATIONS OF DRUG AND HEME METABOLIZING ENZYMES DURING LIVER REGENERATION
- EFFECT OF HEAVY METALS ON SOME ENZYMES OF RAT LIVER AND FACTORS WHICH MODIFY THE METAL ACTIONS, ESPECIALLY OF CADMIUM
- INHIBITION OF MONOAMINE OXIDASE BY 3-METHYL-4-DIMETHYLAMINO AZOBENZENE (3-Me-DAB) IN RAT LIVER MITOCHONDRIA
- Induction of Light Dependent Pyruvate Transport into Chloroplasts of Mesembryanthemum crystallinum by Salt Stress
- Na^+-INDUCED ENHANCEMENT OF PYRUVATE TRANSPORT INTO THE CHLOROPLASTS ISOLATED FROM THE CAM MODE OF Mesembryanthemum crystallinum.
- COMPARISON OF PYRUVATE UPTAKE INTOMESOPHYLL CHLOROPLAST BETWEEN C_3 - AND CAM-FORM OFMESEMBRYANTHEMUM CRYSTALLINUM
- EFFECTS OF PASSIVE IMMUNIZATION WITH RABBIT ANTI-PHENOBARBITAL IgG ON CYCLOBARBITAL-INDUCED SLEEPING TIME AND HEPATIC ENZYME ACTIVITIES OF C3H MICE
- TRIMETHADIONE AS A MODEL DRUG FOR THE EVALUATION OF HEPATIC DRUG-METABOLIZING CAPACITY IN NORMAL AND D-GALACTOSAMINE INTOXICATED RATS
- PRODUCTION OF TOLERANCE TO FENITROTHION I N MALE RATS
- The effect of H2-receptor antagonists on antipyrine and pentobarbital metabolism in male and female rats.
- Early effects of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene on mitochondrial outer membrane enzyme activities of rat liver.
- The role of vagal reflex in mechanism of secretagogic action of bromhexine.