TRIMETHADIONE AS A MODEL DRUG FOR THE EVALUATION OF HEPATIC DRUG-METABOLIZING CAPACITY IN NORMAL AND D-GALACTOSAMINE INTOXICATED RATS

スポンサーリンク

概要

• 論文の詳細を見る
• 社団法人 日本薬理学会の論文

著者

• Kuroiwa Yukio

  Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University

• Yoshida Takemi

  Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University

• KINOSHITA HARUKI

  Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University

• Tanaka Einosuke

  Institute Of Community Medicine And Institute Of Clinical Medicine University Of Tsukuba

• Tanaka Einosuke

  Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University

• Kinoshita Haruki

  Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University

• YOSHIDA Takemi

  Department of Biochemical Toxicology, School of Pharmaceutical Science, Showa University

• KUROIWA Yukio

  Department of Biochemical Toxicology, School of Pharmaceutical Science, Showa University

関連論文

• Recreational drugs, 3,4-Methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA) and diphenylprolinol, inhibit neurite outgrowth in PC12 cells
• Salbutamol inhibits lipopolysaccharide-induced inflammatory responses in rat peritoneal macrophages
• TRIMETHADIONE TOLERANCE TEST FOR EVALUATION OF FUNCTIONAL RESERVE OF THE LIVER IN PATIENTS WITH LIVER CIRRHOSIS AND ESOPHAGEAL VARICES
• THE EFFECT OF INDOMETHACIN ON HEPATIC DRUG-OXIDIZING CAPACITY IN THE RAT : TRIMETHADIONE AND ANTIPYRINE METABOLISM AS AN INDICATOR
• A METHOD FOR ESTIMATION OF HEPATIC DRUG-METABOLIZING CAPACITY : DETERMINATION OF CONCENTRATION OF TRIMETHADIONE AND ITS METABOLITE IN HUMAN SERUM
• Detection of Bisphenol-A in Dental Materials by Gas Chromatography-Mass Spectrometry
• Possible role of inflammatory cytokines in liver injury caused by cocaine (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• SELECTIVE EFFECT OF CHRONIC LEAD INGESTION III : EFFECT ON DOPAMINE β-HYDROXYLASE ACTIVITY IN BRAIN REGIONS OF RATS
• SELECTIVE EFFECT OF CHRONIC LEAD INGESTION ON TYROSINE HYDROXYLASE ACTIVITY IN BRAIN REGIONS OF RATS
• Simple and simultaneous determination for twelve phenothiazines in human serum by reversed-phase high-performance liquid chromatography
• Forensic analysis of eleven cyclic antidepressants in human biological samples using a new reversed-phase chromatographic column of 2μm porous microspherical silica gel
• Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-μm porous microspherical silica gel
• TISSUE- AND DOSE-DEPENDENT ALTERATION OF STRESS-INDUCIBLE PROTEINS BY β_2-ADRENOCEPTOR AGONIST, SALBUTAMOL, IN RATS
• QUANTITATIVE ESTIMATION OF MYOCARDIAL FIBROSIS BASED ON RECEPTOR OCCUPANCY FOR β_2-ADRENERGIC RECEPTOR AGONISTS IN RATS
• PHARMACOKINETIC STUDIES OF TRIMETHADIONE AND ITS METABOLITE IN RATS WITH CHEMICAL-INDUCED LIVER INJURY
• A USEFUL MEASURE OF HEPATIC DRUG METABOLISM : TRIMETHADIONE ELIMINATION AS AN INDICATOR
• Establishment and Peculiarity of Ouabain-resistant THP-1 cells
• COMPARISON OF THE EFFECT OF AN EQUIMOLAR AND LOW DOSE OF FENITROTHION AND METHYLPARATHION ON THEIR OWN METABOLISM IN RAT LIVER
• PROTECTIVE EFFECTS OF DIISOPROPYL 1, 3-DITHIOL-2-YLIDENE MALONATE (NKK-105) ON LIVER INJURY BY CARBON TETRACHLORIDE (CCl_4)
• ALTERATIONS OF HEPATIC MITOCHONDRIAL MONOAMINE OXIDASE ACTIVITY OF RATS DURING 2-ACETYLAMINOFLUORENE FEEDING
• Induction and Inhibition of Cytochrome P450 and Drug-Metabolizing Enzymes by Climbazole
• SEX-RELATED EFFECT OF HEMIN ON CYTOCHROME P450 AND DRUG-METABOLIZING ENZYMES IN RAT LIVER
• Antigenic characterization in ampiroxicam-induced photosensitivity using an in vivo model of contact hypersensitivity
• Determination of plasma bromvalerylurea and its main metabolite by a simple high-performance liquid chromatographic method and quantitation of bromide by energy dispersive X-ray spectrometry in carbon tetrachloride-intoxicated rats
• INTEGRATED NMR-BASED METABONOMIC INVESTIGATION OF EARLY METABOLIC EFFECTS OF ETHYLENE GLYCOL MONOMETHYL ETHER (EGME) ON MALE REPRODUCTIVE ORGANS IN RATS
• Induction of oxidative stress responsive proteines by methyl methanesulfonate, which produces reproductive toxicity (DEVELOPMENT AND REPRODUCTION) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• TISSUE-DEPENDENT INDUCTION OF HEME OXYGENASE-1 AND METALLOTHIONEIN-1/2 BY METHYL METHANESULFONATE
• Simultaneous determination of flunitrazepam and 7-aminoflunitrazepam in human serum by ion trap gas chromatography-tandem mass spectrometry
• Age-related changes in hepatic drug-oxidizing activity using trimethadione as a probe drug in human
• STUDIES ON THE MECHANISM OF INTERACTION BETWEEN METHAMPHETAMINE AND QUININE IN RATS
• Bisphenol-A contents in materials used in pediatric dentistry
• Simultaneous determination of three local anesthetic drugs from the pipecoloxylidide group in human serum by high-performance liquid chromatography
• Regulation of ERK-Mediated Signal Transduction by p38 MAP Kinase in Human Monocytic THP-1 Cells
• INDUCTION OF HEPATIC CYP2B1/2 BY A TERATOGENIC COMPOUND cis-1-[-4-P-MENTHANE-8-YLOXY)PHENYL]PIPERADINE(YM9429)IN RATS
• Selective Inhibition of Chondrogenic Differentiation in Embryonic Cells by a Teratogenic Compound
• Possible Role of Glutathione Depletion in the Induction of Rate-Limiting Enzymes Involved in Heme Degradation and Polyamine Biosynthesis in the Liver of Rats
• Comparative Studies on the Inducing Effects of Cobalt Chloride and Co-Protoporphyrin on Hepatic Ornithine Decarboxylase and Heme Oxygenase in Rats
• DEPLETION OF HEPATIC GLUTATHIONE IS FOLLOWED BY THE INDUCTION OF HEME OXYGENASE AND CHANGES IN DRUG-METABOLIZING ENZYMES
• Relationship between Hepatic Glutathione Consumption and the Induction of Enzymes Involved in Polyamine Biosynthesis Evoked by Various Drugs and Chemicals (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
• EVALUATION OF THE INDUCTION OF HEPATIC DRUG-METABOLIZING ENZYMES IN THE RAT AND MOUSE TREATED WITH TEMAZEPAM USING TRIMETHADIONE AS THE INDICATOR
• RELATIONSHIP BETWEEN TRIMETHADIONE METABOLISM AND HEPATIC DRUG-OXIDIZING ENZYME ACTIVITIES IN DIFFERENT ANIMAL SPECIES
• STUDIES ON THE TRIMETHADIONE METABOLISM AS A TOOL FOR THE ASSESSMENT OF DRUG-METABOLIZING CAPACITY USING PLASMA AND URINE OF RATS PRETREATED WITH PHENOBARBITAL AND 3-METHYLCHOLANTHRENE
• DETERMINATION OF PLASMA TRIMETHADIONE AND ITS METABOLITE IN CARBON TETRACHLORIDE-INTOXICATED RATLIVER : A USEFUL TOOL FOR ESTIMATION OF HEPATIC DRUGMETABOLIZING CAPACITY
• SALIVA LEVELS OF TRIMETHADIONE AND ITS METABOLITE AS AN INDEX OF DRUG METABOLIZING ACTIVITY IN RATS
• Rharmacokinetics of Cephaeline and Emetine in Ipecac Syrup in Rats and Dogs
• A SUSTAINED INCREASE OF MICROSOMAL HEME OXYGENASE ACTIVITY FOLLOWING TREATMENT OF RATS WITH BACILLUS CALMETTE-GUERIN AND CORYNEBACTERIUM PARVUM : ITS POSSIBLE RELATION TO THE DECREASE OF CYTOCHROME P-450 CONTENT
• ALTERATIONS OF HEPATIC δ-AMINOLEVULINIC ACID SYNTHETASE, HEME OXYGENASE, MICROSOMAL CYTOCHROME CONTENT AND DRUG METABOLISM IN RATS BEARING ASCITIC TUMORS AH 13,AH 66 AND AH 414 AND A 3-METHYLCHOLANTHRENE INDUCED TUMOR
• INDUCTION OF HEME OXYGENASE AND INHIBITION OF δ-AMINOLEVULINIC ACID SYNTHETASE OF RAT LIVER BY THIOACETAMIDE AND THIOACETAMIDE-S-OXIDE
• The Metabolism and Excretion of Trimethadione in Patients with Percutaneous Transhepatic Biliary Drainage and Renal Dysfunction
• Sex-Related Differences in Hepatic Drug-Oxidizing Capacity of Streptozotocin-Induced Diabetic Rats
• TRIMETHADIONE METABOLISM IN PATIENTS WITH NORMAL LIVER AND IN PATIENTS WITH CHRONIC LIVER DISEASE
• HEPATIC TRIMETHADIONE-OXIDIZING CAPACITY REMAINS NORMAL IN PATIENTS WITH EXTRAHEPATIC CHOLELITHIASIS
• SELECTIVE EFFECT OF CHRONIC LEAD INGESTION II : EFFECT ON PHENYLETHANOLAMINE N-METHYLTRANSFERASE ACTIVITY IN BRAIN REGIONS OF RATS
• Simultaneous determination of carbamazepine and its metabolites in plasma from carbon tetrachloride-intoxicated rats using a new reversed-phase chromatographic column of 2-μm porous microspherical silica gel
• Simultaneous determination of plasma phenytoin and its primary hydroxylated metabolites in carbon tetrachloride-intoxicated rats by high-performance liquid chromatography
• Effect of propofol on ropivacaine metabolism in human liver microsomes
• Effects of clonidine on lidocaine metabolism in human or rat liver microsomes
• Propofol inhibits lidocaine metabolism in human and rat liver microsomes
• SIMULTANEOUS INDUCTION OF ORNITHINE DECARBOXYLASE AND HEME OXYGENASE UNDER VARIOUS EXPERIMENTAL CONDITIONS
• Clinical significance of the trimethadione tolerance test in chronic hepatitis: A useful indicator of hepatic drug metabolizing capacity
• Metallothionein Synthesis Induced by Interferon α/β in Mice of Various Zinc Status
• Metabolism of Ipecac Alkaloids Cephaeline and Emetine by Human Hepatic Microsomal Cytochrome P450s, and Their Inhibitory Effects on P450 Enzyme Activities
• Determination of muscimol and ibotenic acid in Amanita mushrooms by high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry
• Comparison of in vitro metabolic conversion of capecitabine to 5-FU in rats, mice, monkeys and humans - toxicological implications
• POTENTIATION OF AFLATOXIN B_1 INDUCED HEPATOTOXICITY IN MALE WISTAR RATS WITH ETHANOL PRETREATMENT
• AN INDUCTION OF HEME OXYGENASE AND ITS POSSIBLE RELATION TO THE DECREASE OF CYTOCHROME P-450 CONTENT DURING LIVER REGENERATION
• ALTERATIONS OF DRUG AND HEME METABOLIZING ENZYMES DURING LIVER REGENERATION
• EFFECT OF HEAVY METALS ON SOME ENZYMES OF RAT LIVER AND FACTORS WHICH MODIFY THE METAL ACTIONS, ESPECIALLY OF CADMIUM
• Interleukin-1 Controls the Constitutive Expression of the Cyp7a1 Gene by Regulating the Expression of Cyp7a1 Transcriptional Regulators in the Mouse Liver
• The mechanism of induction of HO-1 gene transactivation by 4-HNE.(GENERAL SESSION BY POSTER PRESENTATION)(ACTIVE OXYGEN ETC)
• O-56 Involvement of aPKC in Oxidative Stress-induced Heme Oxygenase-1.(Proceedings of the 27th Annual Meeting)
• INHIBITION OF MONOAMINE OXIDASE BY 3-METHYL-4-DIMETHYLAMINO AZOBENZENE (3-Me-DAB) IN RAT LIVER MITOCHONDRIA
• Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-1
• EFFECTS OF PASSIVE IMMUNIZATION WITH RABBIT ANTI-PHENOBARBITAL IgG ON CYCLOBARBITAL-INDUCED SLEEPING TIME AND HEPATIC ENZYME ACTIVITIES OF C3H MICE
• ANALYSIS OF THE EXPRESSION OF HEME OXYGENASE-1 GENE IN HUMAN ALVEOLAR EPITHELIAL CELLS EXPOSED TO CIGARETTE SMOKE CONDENSATE
• Nrf2-DEPENDENT GENE EXPRESSIONS : A MOLECULAR TOXICOLOGICAL ASPECT
• Biological Surveillance and Defense Mechanism for Drug Toxicity and Its Breakdown(SYMPOSIUM 1 : MECHANISMS OF HEPATOTOXIC EFFECTS)
• Comparison of in vitro metabolic conversion of capecitabine to 5-FU in rats, mice, monkeys and humans - toxicological implications
• TRIMETHADIONE AS A MODEL DRUG FOR THE EVALUATION OF HEPATIC DRUG-METABOLIZING CAPACITY IN NORMAL AND D-GALACTOSAMINE INTOXICATED RATS
• Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-1
• 6-Mercaptopurine-induced histopathological changes and xanthine oxidase expression in rat placenta
• PRODUCTION OF TOLERANCE TO FENITROTHION I N MALE RATS
• Possible Involvement of Transient Receptor Potential Channels in Electrophile-Induced Insulin Secretion from RINm5F Cells
• Involvement of Interleukin-1 in Lead Nitrate-Induced Hypercholesterolemia in Mice
• The effect of H2-receptor antagonists on antipyrine and pentobarbital metabolism in male and female rats.
• Early effects of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene on mitochondrial outer membrane enzyme activities of rat liver.
• The Impact of Liver Cirrhosis and Cholelithiasis on Phase I and II Reactions Using Antipyrine and Trimethadione as a Model Substrate.
• The role of vagal reflex in mechanism of secretagogic action of bromhexine.
• Antipyrine metabolism in female Lewis and Dark Agouti strains of rats, which are extensive and poor metabolizers of debrisoquine, respectively.
• Microarray analysis of 6-mercaptopurine-induced-toxicity-related genes and microRNAs in the rat placenta
• Influence of short-term water deprivation on kinetics of trimethadione and its metabolite in rats.

もっと見る 閉じる

スポンサーリンク