The Metabolism and Excretion of Trimethadione in Patients with Percutaneous Transhepatic Biliary Drainage and Renal Dysfunction
スポンサーリンク
概要
- 論文の詳細を見る
The metabolism and excretion of trimethadione (TMO) following an oral dose of 4 mg/kg has been examined in patients with percutaneous transhepatic biliary drainage (PTBD) and renal dysfunction. Biliary excretion as the total amount of TMO and its metabolite, dimethadione (DMO) was 2.0% of the dose during 0 to 48 h after TMO administration in patients with PTBD. Total urinary excretion (0-48 h) was 2.8% and 3.0% of the dose in healthy volunteers and patients with renal dysfunction, respectively. The serum DMO/TMO ratio at 4 h after oral dosing in patients of PTBD and renal dysfunction was not significantly changed in comparison with the ratio reported previously in healthy volunteers. The elimination half-life of TMO was also not altered in patients with PTBD in comparison with that reported previously in volunteers. These results suggests that metabolism and urinary and biliary excretion of TMO are not changed in patients with PTBD and renal dysfunction.
- 公益社団法人日本薬学会の論文
著者
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Ishikawa Akio
筑波大学
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Misawa S
Inst.of Commun.med
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Misawa Shogo
Institute Of Community Medicine University Of Tsukuba
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Fukao Katashi
Institute Of Clinical Medicine University Of Tsukuba
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Ishikawa Akio
Institute Of Clinical Medicine University Of Tsukuba
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Ishikawa Akio
Inst.of Clin.med. Tsukuba Univ.
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Tanaka Einosuke
Institute Of Community Medicine And Institute Of Clinical Medicine University Of Tsukuba
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Tanaka E
Univ. Tsukuba Ibaraki Jpn
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Takabatake E
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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YAMAMOTO Yuji
Inst.of Clin.Med., Tsukuba Univ.
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YAMAMOTO Yuji
Institute of Community Medicine and Institute of Clinical Medicine, University of Tsukuba
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IWASAKI Yoji
Institute of Community Medicine and Institute of Clinical Medicine, University of Tsukuba
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Iwasaki Yoji
Institute Of Community Medicine And Institute Of Clinical Medicine University Of Tsukuba
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Takabatake E
Inst.of Commun.med
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Tanaka Einosuke
Inst.of Commun.med
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Ishikawa Akio
Institute For Solid State Physics University Of Tokyo
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Yamamoto Yuji
Inst.of Clin.med. Tsukuba Univ.
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MISAWA Shogo
Institute of Community Medicine
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IWASAKI Yoji
Institute of Clinical Medicine, University of Tsukuba
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