Effects of Mushroom Toxins on Glycogenolysis : Comparison of Toxicity of Phalloidin, α-Amanitin and DL-Propargylglycine in Isolated Rat Hepatocytes
スポンサーリンク
概要
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The effects of phalloidin and α-amanitin as toxins of Amanita species and DL-propargylglycine identified from A. abrupta on the glycogenolysis in isolated rat hepatocytes were investigated. Phalloidin decreased glycogen content and activated phosphorylase α activity remarkably. α-Amanitin also decreased glycogen content significantly but activated phosphorylase α activity slightly. DL-Propargylglycine slightly affected glycogenolysis. Phalloidin, which most affected glycogenolysis among the three compounds mentioned above, elevated cytosolic Ca^<2+> concentration ([Ca^<2+>]_i) and ^<45>Ca uptake into cells. Phalloidin depressed slightly ^3H-inositol incorporation into phosphatidylinositol (PI) and remarkably phosphatidylinosito 4,5-bisphosphate (PIP_2) but increased phosphoinositides breakdown. These results suggest that phalloidin alters phosphoinositides turnover and intracellular Ca^<2+> homeostasis, subsequently activates phosphorylase α, resulting in glycogenolysis in isolated rat hepatocytes.
- 公益社団法人日本薬学会の論文
著者
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Fujii Shinobu
Department of Mathematics, Hiroshima University
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TAKABATAKE Eigo
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
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KAWAJI AKIKO
Department of Micro System Engineering, Graduate School of Engineering, Nagoya University
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Takabatake E
Setsunan Univ. Osaka Jpn
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Takabatake Eigo
Department Of Pharmaceutical Sciences Institute Of Public Health
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Yamauchi Kiyotaka
Department Of Toxicology Faculty Of Pharmaceutical Sciences
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Tanaka E
Univ. Tsukuba Ibaraki Jpn
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Kawaji A
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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Kawaji Akiko
Department Of Micro System Engineering Graduate School Of Engineering Nagoya University
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Kawaji Akiko
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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Natsuki Reiko
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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Fujii Shinobu
Department Of Toxicology Faculty Of Pharmaceutical Sciences
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Fujii Shinobu
Department Of Dermatology Osaka Red Cross Hospital
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Takabatake E
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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YAMAURA Yoshio
Nagano Research Institute for Health and Pollution Komeura
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Yamaura Yoshio
Nagano Research Institute For Health And Pollution
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Takabatake E
Inst.of Commun.med
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Tanaka Einosuke
Inst.of Commun.med
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